BACKGROUND: Chronic kidney disease (CKD) is strongly associated with coronary artery disease (CAD), although the underlying pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) has recently been recognized as an important source of various pro-inflammatory cytokines causing coronary atherosclerosis. This study investigated the relationship between CKD and EAT volume in association with high-risk plaque. METHODS AND RESULTS: The study included 275 patients with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m(2)who underwent multidetector computed tomography (MDCT) for the evaluation of CAD. Patients were classified, according to eGFR, into a CKD group (30≤eGFR<60 ml/min/1.73 m(2)) or a non-CKD group (eGFR ≥60 ml/min/1.73 m(2)). MDCT was used to assess coronary plaque morphology and EAT volume. One hundred and ten patients with CKD were more likely to be older, have higher prevalence of hypertension, lower serum HDL-C, higher serum CRP, and larger EAT volume, than those without CKD (all P<0.01). On multivariate analysis age, hypertension, and EAT volume were significantly associated with eGFR (all P<0.01). EAT volume was associated with the presence of high-risk plaque, independent of traditional CAD risk factors (P=0.003). CONCLUSIONS: Patients with CKD had significantly increased EAT volume, which could be associated with the presence of high-risk plaque.
BACKGROUND:Chronic kidney disease (CKD) is strongly associated with coronary artery disease (CAD), although the underlying pathophysiological mechanism remains unclear. Epicardial adipose tissue (EAT) has recently been recognized as an important source of various pro-inflammatory cytokines causing coronary atherosclerosis. This study investigated the relationship between CKD and EAT volume in association with high-risk plaque. METHODS AND RESULTS: The study included 275 patients with an estimated glomerular filtration rate (eGFR) ≥30 ml/min/1.73 m(2)who underwent multidetector computed tomography (MDCT) for the evaluation of CAD. Patients were classified, according to eGFR, into a CKD group (30≤eGFR<60 ml/min/1.73 m(2)) or a non-CKD group (eGFR ≥60 ml/min/1.73 m(2)). MDCT was used to assess coronary plaque morphology and EAT volume. One hundred and ten patients with CKD were more likely to be older, have higher prevalence of hypertension, lower serum HDL-C, higher serum CRP, and larger EAT volume, than those without CKD (all P<0.01). On multivariate analysis age, hypertension, and EAT volume were significantly associated with eGFR (all P<0.01). EAT volume was associated with the presence of high-risk plaque, independent of traditional CAD risk factors (P=0.003). CONCLUSIONS:Patients with CKD had significantly increased EAT volume, which could be associated with the presence of high-risk plaque.
Authors: Turgay Saritas; Sebastian Daniel Reinartz; Jennifer Nadal; Jonas Schmoee; Matthias Schmid; Mohamed Marwan; Stephan Achenbach; Stefan Störk; Christoph Wanner; Kai-Uwe Eckardt; Jürgen Floege; Markus Peter Schneider; Georg Schlieper Journal: Clin Kidney J Date: 2019-04-08
Authors: Nitesh Nerlekar; Adam J Brown; Rahul G Muthalaly; Andrew Talman; Thushan Hettige; James D Cameron; Dennis T L Wong Journal: J Am Heart Assoc Date: 2017-08-23 Impact factor: 5.501
Authors: Luis D'Marco; Maria Jesús Puchades; Jose Luis Gorriz; Maria Romero-Parra; Marcos Lima-Martínez; Carlos Soto; Valmore Bermúdez; Paolo Raggi Journal: Int J Mol Sci Date: 2020-02-01 Impact factor: 5.923
Authors: Sang Heon Suh; Tae Ryom Oh; Hong Sang Choi; Chang Seong Kim; Joongyub Lee; Yun Kyu Oh; Ji Yong Jung; Kyu-Beck Lee; Kook-Hwan Oh; Seong Kwon Ma; Eun Hui Bae; Soo Wan Kim Journal: Front Cardiovasc Med Date: 2022-01-13