| Literature DB >> 26496607 |
Wenyang Li1, Mengdi Ma1, Ying Feng1, Hongjiang Li1, Yichuan Wang1, Yutong Ma1, Mingzhe Li1, Fengying An2, Hongwei Guo3.
Abstract
Ethylene is a gaseous phytohormone that plays vital roles in plant growth and development. Previous studies uncovered EIN2 as an essential signal transducer linking ethylene perception on ER to transcriptional regulation in the nucleus through a "cleave and shuttle" model. In this study, we report another mechanism of EIN2-mediated ethylene signaling, whereby EIN2 imposes the translational repression of EBF1 and EBF2 mRNA. We find that the EBF1/2 3' UTRs mediate EIN2-directed translational repression and identify multiple poly-uridylates (PolyU) motifs as functional cis elements of 3' UTRs. Furthermore, we demonstrate that ethylene induces EIN2 to associate with 3' UTRs and target EBF1/2 mRNA to cytoplasmic processing-body (P-body) through interacting with multiple P-body factors, including EIN5 and PABs. Our study illustrates translational regulation as a key step in ethylene signaling and presents mRNA 3' UTR functioning as a "signal transducer" to sense and relay cellular signaling in plants. VIDEO ABSTRACT.Entities:
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Year: 2015 PMID： 26496607 DOI： 10.1016/j.cell.2015.09.037
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582