Literature DB >> 26494870

Aetiological overlap between obsessive-compulsive related and anxiety disorder symptoms: multivariate twin study.

Clara López-Solà1, Leonardo F Fontenelle1, Minh Bui1, John L Hopper1, Christos Pantelis1, Murat Yücel1, José M Menchón1, Pino Alonso1, Ben J Harrison2.   

Abstract

BACKGROUND: The aetiological boundary between obsessive-compulsive related disorders (OCRDs) including obsessive-compulsive disorder (OCD) and anxiety disorders is unclear and continues to generate debate. AIMS: To determine the genetic overlap and the pattern of causal relationships among OCRDs and anxiety disorders.
METHOD: Multivariate twin modelling methods and a new regression analysis to infer causation were used, involving 2495 male and female twins.
RESULTS: The amount of common genetic liability observed for OCD symptoms was higher when considering anxiety disorders and OCRDs in the model v. modelling OCRD symptoms alone. OCD symptoms emerged as risk factors for the presence of generalised anxiety, panic and hoarding symptoms, whereas social phobia appeared as a risk factor for OCD symptoms.
CONCLUSIONS: OCD represents a complex phenotype that includes important shared features with anxiety disorders and OCRDs. The novel patterns of risk identified between OCD and anxiety disorder may help to explain their frequent co-occurrence. © The Royal College of Psychiatrists 2016.

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Year:  2015        PMID: 26494870     DOI: 10.1192/bjp.bp.114.156281

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  5 in total

1.  Impact of the fear of Covid-19 infection on intent to breastfeed; a cross sectional survey of a perinatal population in Qatar.

Authors:  Shuja Mohd Reagu; Salwa Abuyaqoub; Isaac Babarinsa; Nisha Abdul Kader; Thomas Farrell; Stephen Lindow; Nahid M Elhassan; Sami Ouanes; Noor Bawazir; Anum Adnan; Dina Hussain; Malika Boumedjane; Majid Alabdulla
Journal:  BMC Pregnancy Childbirth       Date:  2022-02-05       Impact factor: 3.007

Review 2.  Assessing the evidence for shared genetic risks across psychiatric disorders and traits.

Authors:  Joanna Martin; Mark J Taylor; Paul Lichtenstein
Journal:  Psychol Med       Date:  2017-12-04       Impact factor: 7.723

3.  Heritability of overlapping impulsivity and compulsivity dimensional phenotypes.

Authors:  Jeggan Tiego; Samuel R Chamberlain; Ben J Harrison; Andrew Dawson; Lucy Albertella; George J Youssef; Leonardo F Fontenelle; Murat Yücel
Journal:  Sci Rep       Date:  2020-09-01       Impact factor: 4.379

4.  COVID-19 Pandemic and Mental Health: Prevalence and Correlates of New-Onset Obsessive-Compulsive Symptoms in a Canadian Province.

Authors:  Adam Abba-Aji; Daniel Li; Marianne Hrabok; Reham Shalaby; April Gusnowski; Wesley Vuong; Shireen Surood; Nnamdi Nkire; Xin-Min Li; Andrew J Greenshaw; Vincent I O Agyapong
Journal:  Int J Environ Res Public Health       Date:  2020-09-24       Impact factor: 3.390

5.  Involvement of fear, incompleteness, and disgust during symptoms of pediatric obsessive-compulsive disorder.

Authors:  Matti Cervin; Sean Perrin; Elin Olsson; Emma Claesdotter-Knutsson; Magnus Lindvall
Journal:  Eur Child Adolesc Psychiatry       Date:  2020-03-24       Impact factor: 4.785

  5 in total

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