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Literature DB >> 26493358

Design, synthesis, and characterization of nucleosomes containing site-specific DNA damage.

Abstract

How DNA damaged is formed, recognized, and repaired in chromatin is an area of intense study. To better understand the structure activity relationships of damaged chromatin, mono and dinucleosomes containing site-specific damage have been prepared and studied. This review will focus on the design, synthesis, and characterization of model systems of damaged chromatin for structural, physical, and enzymatic studies.

Entities: CellLine Chemical Disease Gene Species

Keywords: AP sites; Chromatin; DNA damage; DNA photoproducts; DNA repair; Dinucleosome; Histones; Linker; Nucleosome; Photocaged; Solid phase DNA synthesis

Mesh：

Substances：
Nucleosomes
DNA

Year: 2015 PMID： 26493358 PMCID： PMC4688083 DOI： 10.1016/j.dnarep.2015.09.025

Source DB: PubMed Journal: DNA Repair (Amst) ISSN： 1568-7856

79 in total

1. RNA and protein metabolism in the maturation of the nucleated chicken erythrocyte.

Authors: I L CAMERON; D M PRESCOTT
Journal: Exp Cell Res Date: 1963-05 Impact factor: 3.905

2. Platinum anticancer drug damage enforces a particular rotational setting of DNA in nucleosomes.

Authors: Andrew J Danford; Dong Wang; Qun Wang; Thomas D Tullius; Stephen J Lippard
Journal: Proc Natl Acad Sci U S A Date: 2005-08-22 Impact factor: 11.205

Review 3. Structural and functional dynamics of human centromeric chromatin.

Authors: Mary G Schueler; Beth A Sullivan
Journal: Annu Rev Genomics Hum Genet Date: 2006 Impact factor: 8.929

4. Accommodation and repair of a UV photoproduct in DNA at different rotational settings on the nucleosome surface.

Authors: Zeljko M Svedruzić; Chenbo Wang; Joseph V Kosmoski; Michael J Smerdon
Journal: J Biol Chem Date: 2005-10-06 Impact factor: 5.157

5. ATP-dependent chromatin remodeling is required for base excision repair in conventional but not in variant H2A.Bbd nucleosomes.

Authors: Hervé Menoni; Didier Gasparutto; Ali Hamiche; Jean Cadet; Stefan Dimitrov; Philippe Bouvet; Dimitar Angelov
Journal: Mol Cell Biol Date: 2007-06-25 Impact factor: 4.272

6. Base excision repair in nucleosomes lacking histone tails.

Authors: Brian C Beard; Jill J Stevenson; Samuel H Wilson; Michael J Smerdon
Journal: DNA Repair (Amst) Date: 2005-02-03

7. Cisplatin damage overrides the predefined rotational setting of positioned nucleosomes.

Authors: Matthias Ober; Stephen J Lippard
Journal: J Am Chem Soc Date: 2007-04-14 Impact factor: 15.419

8. Synthesis and nucleosome structure of DNA containing a UV photoproduct at a specific site.

Authors: J V Kosmoski; M J Smerdon
Journal: Biochemistry Date: 1999-07-20 Impact factor: 3.162

9. Initiation of base excision repair of oxidative lesions in nucleosomes by the human, bifunctional DNA glycosylase NTH1.

Authors: Amalthiya Prasad; Susan S Wallace; David S Pederson
Journal: Mol Cell Biol Date: 2007-10-08 Impact factor: 4.272

10. Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle.

Authors: Yasuo Tsunaka; Naoko Kajimura; Shin-ichi Tate; Kosuke Morikawa
Journal: Nucleic Acids Res Date: 2005-06-10 Impact factor: 16.971

6 in total

Review 1. UV-Induced DNA Damage and Mutagenesis in Chromatin.

Authors: Peng Mao; John J Wyrick; Steven A Roberts; Michael J Smerdon
Journal: Photochem Photobiol Date: 2016-11-07 Impact factor: 3.421

2. Vicinal abasic site impaired processing of a Tg:G mismatch and 8-oxoguanine lesions in three-component bistranded clustered DNA damage.

Authors: Bhavini Kumari; Pravin Jha; Kislay K Sinha; Prolay Das
Journal: RSC Adv Date: 2018-05-16 Impact factor: 4.036