Literature DB >> 28482029

From compliment to insult: genetics of the complement system in physiology and disease in the human retina.

Robert F Mullins1,2, Alasdair N Warwick3, Elliott H Sohn1,2, Andrew J Lotery4.   

Abstract

Age-related macular degeneration (AMD) is a major cause of visual impairment that affects the central retina. Genome wide association studies and candidate gene screens have identified members of the complement pathway as contributing to the risk of AMD. In this review, we discuss the complement system, its importance in retinal development and normal physiology, how its dysregulation may contribute to disease, and how it might be targeted to prevent damage to the aging choriocapillaris in AMD.
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Year:  2017        PMID： 28482029      PMCID： PMC5886463          DOI： 10.1093/hmg/ddx181

Source DB:  PubMed          Journal:  Hum Mol Genet        ISSN： 0964-6906            Impact factor:   6.150


  84 in total

1.  Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.

Authors:  Jaimie Hoh Kam; James E Morgan; Glen Jeffery
Journal:  Exp Eye Res       Date:  2016-07-07       Impact factor: 3.467

Review 2.  The central role of the alternative complement pathway in human disease.

Authors:  Joshua M Thurman; V Michael Holers
Journal:  J Immunol       Date:  2006-02-01       Impact factor: 5.422

3.  Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes.

Authors:  Kalliopi Stasi; Dalia Nagel; Xiaoyan Yang; Rong-Fang Wang; Lizhen Ren; Steven M Podos; Thom Mittag; John Danias
Journal:  Invest Ophthalmol Vis Sci       Date:  2006-03       Impact factor: 4.799

4.  Complement factor H variant increases the risk of age-related macular degeneration.

Authors:  Jonathan L Haines; Michael A Hauser; Silke Schmidt; William K Scott; Lana M Olson; Paul Gallins; Kylee L Spencer; Shu Ying Kwan; Maher Noureddine; John R Gilbert; Nathalie Schnetz-Boutaud; Anita Agarwal; Eric A Postel; Margaret A Pericak-Vance
Journal:  Science       Date:  2005-03-10       Impact factor: 47.728

5.  Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration.

Authors:  Kristin J Meyers; Zhe Liu; Amy E Millen; Sudha K Iyengar; Barbara A Blodi; Elizabeth Johnson; D Max Snodderly; Michael L Klein; Karen M Gehrs; Lesley Tinker; Gloria E Sarto; Jennifer Robinson; Robert B Wallace; Julie A Mares
Journal:  Ophthalmology       Date:  2015-09-06       Impact factor: 12.079

Review 6.  Comparative functional evolution of human and mouse CR1 and CR2.

Authors:  Amanda C Jacobson; John H Weis
Journal:  J Immunol       Date:  2008-09-01       Impact factor: 5.422

7.  Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.

Authors:  Ian Catchpole; Volker Germaschewski; Jaimie Hoh Kam; Peter Lundh von Leithner; Susannah Ford; Gerald Gough; Peter Adamson; Philip Overend; Jan Hilpert; Francisco J López; Yin Shan Eric Ng; Pete Coffey; Glen Jeffery
Journal:  PLoS One       Date:  2013-06-14       Impact factor: 3.240

8.  Analysis of rare variants in the CFH gene in patients with the cuticular drusen subtype of age-related macular degeneration.

Authors:  Maheswara R Duvvari; Nicole T M Saksens; Johannes P H van de Ven; Yvonne de Jong-Hesse; Tina Schick; Willy M Nillesen; Sascha Fauser; Lies H Hoefsloot; Carel B Hoyng; Eiko K de Jong; Anneke I den Hollander
Journal:  Mol Vis       Date:  2015-03-15       Impact factor: 2.367

9.  Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein.

Authors:  Y U Kim; T Kinoshita; H Molina; D Hourcade; T Seya; L M Wagner; V M Holers
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307

10.  Connecting the innate and adaptive immune responses in mouse choroidal neovascularization via the anaphylatoxin C5a and γδT-cells.

Authors:  Beth Coughlin; Gloriane Schnabolk; Kusumam Joseph; Himanshu Raikwar; Kannan Kunchithapautham; Krista Johnson; Kristi Moore; Yi Wang; Bärbel Rohrer
Journal:  Sci Rep       Date:  2016-03-31       Impact factor: 4.379
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  10 in total

1.  Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization.

Authors:  Nathaniel Parsons; Balasubramaniam Annamalai; Elisabeth Obert; Gloriane Schnabolk; Stephen Tomlinson; Bärbel Rohrer
Journal:  Mol Immunol       Date:  2019-02-12       Impact factor: 4.407

Review 2.  Genetics and genetic testing for age-related macular degeneration.

Authors:  A Warwick; A Lotery
Journal:  Eye (Lond)       Date:  2017-11-10       Impact factor: 3.775

Review 3.  The role of lymphocytes and phagocytes in age-related macular degeneration (AMD).

Authors:  Verena Behnke; Anne Wolf; Thomas Langmann
Journal:  Cell Mol Life Sci       Date:  2020-01-02       Impact factor: 9.261

Review 4.  C-Reactive Protein As a Mediator of Complement Activation and Inflammatory Signaling in Age-Related Macular Degeneration.

Authors:  Kathleen R Chirco; Lawrence A Potempa
Journal:  Front Immunol       Date:  2018-03-15       Impact factor: 7.561

5.  Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration.

Authors:  Haihan Jiao; Matt Rutar; Nilisha Fernando; Ted Yednock; Sethu Sankaranarayanan; Riemke Aggio-Bruce; Jan Provis; Riccardo Natoli
Journal:  Mol Neurodegener       Date:  2018-08-20       Impact factor: 14.195

6.  A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy.

Authors:  Paul Ibbett; Srinivas V Goverdhan; Elena Pipi; Joe K Chouhan; Eloise Keeling; Elizabeth M Angus; Jenny A Scott; Maureen Gatherer; Anton Page; Jessica L Teeling; Andrew J Lotery; J Arjuna Ratnayaka
Journal:  Sci Rep       Date:  2019-05-16       Impact factor: 4.379

7.  C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa.

Authors:  Sean M Silverman; Wenxin Ma; Xu Wang; Lian Zhao; Wai T Wong
Journal:  J Exp Med       Date:  2019-06-17       Impact factor: 14.307

Review 8.  Complement system and age-related macular degeneration: drugs and challenges.

Authors:  Jiali Wu; Xiaodong Sun
Journal:  Drug Des Devel Ther       Date:  2019-07-19       Impact factor: 4.162

9.  Proteins Associated with Phagocytosis Alteration in Retinal Pigment Epithelial Cells Derived from Age-Related Macular Degeneration Patients.

Authors:  Audrey Voisin; Afsaneh Gaillard; Anaïs Balbous; Nicolas Leveziel
Journal:  Antioxidants (Basel)       Date:  2022-04-05

Review 10.  Epigenetics in age-related macular degeneration: new discoveries and future perspectives.

Authors:  M Gemenetzi; A J Lotery
Journal:  Cell Mol Life Sci       Date:  2020-01-02       Impact factor: 9.261
  10 in total

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