Charles W Lynde1, Anneke Andriessen2, Vince Bertucci3, Catherine McCuaig4, Sandy Skotnicki5, Miriam Weinstein3, Marni Wiseman6, Catherine Zip7. 1. University of Toronto, Toronto, ON, Canada derma@lynderma.com. 2. Andriessen Consultants Malden and UMC St Radboud Nijmegen, Malden, The Netherlands. 3. University of Toronto, Toronto, ON, Canada. 4. University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada. 5. University of Toronto, Toronto, ON, Canada Department of Medicine, Department of Dermatology, University of Toronto, Toronto, Canada. 6. Department of Medical Oncology and Hematology and the Department of Medicine, Section of Dermatology, University of Manitoba, Winnipeg, MB, Canada. 7. University of Calgary, Calgary, AB, Canada.
Abstract
BACKGROUND: Human-associated bacterial communities on the skin, skin microbiome, likely play a central role in development of immunity and protection from pathogens. In atopic patients, the skin bacterial diversity is smaller than in healthy subjects. OBJECTIVE: To review treatment strategies for atopic dermatitis in Canada, taking the skin microbiome concept into account. METHODS: An expert panel of 8 Canadian dermatologists explored the role of skin microbiome in clinical dermatology, specifically looking at atopic dermatitis. RESULTS: The panel reached consensus on the following: (1) In atopic patients, the skin microbiome of lesional atopic skin is different from nonlesional skin in adjacent areas. (2) Worsening atopic dermatitis and smaller bacterial diversity are strongly associated. (3) Application of emollients containing antioxidant and antibacterial components may increase microbiome diversity in atopic skin. CONCLUSION: The skin microbiome may be the next frontier in preventive health and may impact the approach to atopic dermatitis treatment.
BACKGROUND:Human-associated bacterial communities on the skin, skin microbiome, likely play a central role in development of immunity and protection from pathogens. In atopic patients, the skin bacterial diversity is smaller than in healthy subjects. OBJECTIVE: To review treatment strategies for atopic dermatitis in Canada, taking the skin microbiome concept into account. METHODS: An expert panel of 8 Canadian dermatologists explored the role of skin microbiome in clinical dermatology, specifically looking at atopic dermatitis. RESULTS: The panel reached consensus on the following: (1) In atopic patients, the skin microbiome of lesional atopic skin is different from nonlesional skin in adjacent areas. (2) Worsening atopic dermatitis and smaller bacterial diversity are strongly associated. (3) Application of emollients containing antioxidant and antibacterial components may increase microbiome diversity in atopic skin. CONCLUSION: The skin microbiome may be the next frontier in preventive health and may impact the approach to atopic dermatitis treatment.
Authors: Yvonne J Huang; Benjamin J Marsland; Supinda Bunyavanich; Liam O'Mahony; Donald Y M Leung; Antonella Muraro; Thomas A Fleisher Journal: J Allergy Clin Immunol Date: 2017-02-28 Impact factor: 10.793
Authors: Diego G Peroni; Giulia Nuzzi; Irene Trambusti; Maria Elisa Di Cicco; Pasquale Comberiati Journal: Front Immunol Date: 2020-04-23 Impact factor: 7.561