Literature DB >> 2649281

Cellular infiltration in induced rat thyroiditis: phenotypic analysis and relationship to genetic restriction.

H J De Assis-Paiva1, D C Rayner, I M Roitt, A Cooke.   

Abstract

We have investigated the responsiveness to thyroglobulin (Tg) plus complete Freund's adjuvant (CFA) and B. pertussis in a variety of inbred and MHC congenic strains of rats in terms of both Tg-autoantibody titres and histological thyroiditis index. Severity of thyroiditis was strongly Tg-dependent and closely related to the RT.1-MHC haplotype. Phenotypic examination of the inflammatory thyroid infiltrate using single and double indirect immunofluorescence techniques revealed a high proportion of macrophages and T lymphocytes, mainly of the cytotoxic/suppressor subset, in the high responder strains. Thyroid epithelial class II MHC expression although not prominent was strain-restricted and related to the amount of Ia+ leukocyte infiltrate.

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Year:  1989        PMID： 2649281      PMCID： PMC1541870     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

1.  Experimental auto-immune thyroiditis in the rat.

Authors:  H E JONES; I M ROITT
Journal:  Br J Exp Pathol       Date:  1961-12

2.  The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3.

Authors:  C D Dijkstra; E A Döpp; P Joling; G Kraal
Journal:  Immunology       Date:  1985-03       Impact factor: 7.397

3.  Differing responses of inbred rat strains in experimental autoimmune thyrioditis.

Authors:  N R Rose
Journal:  Cell Immunol       Date:  1975-08       Impact factor: 4.868

4.  Autoimmune murine thyroiditis. IV. Localization of genetic control of the immune response.

Authors:  V Tomazic; N R Rose; D C Shreffler
Journal:  J Immunol       Date:  1974-03       Impact factor: 5.422

5.  Susceptibility of inbred rat strains to experimental thyroiditis: quantitation of thyroglobulin-binding cells and assessment of T-cell function in susceptible and non-susceptible strains.

Authors:  W J Penhale; A Farmer; S J Urbaniak; W J Irvine
Journal:  Clin Exp Immunol       Date:  1975-01       Impact factor: 4.330

6.  Autoimmune murine thyroiditis relation to histocompatibility (H-2) type.

Authors:  A O Vladutiu; N R Rose
Journal:  Science       Date:  1971-12-10       Impact factor: 47.728

7.  Characterization of different types of experimental autoimmune thyroiditis in the Buffalo strain rat.

Authors:  S B Cohen; A P Weetman
Journal:  Clin Exp Immunol       Date:  1987-07       Impact factor: 4.330

8.  Hyperinducibility of Ia antigen on astrocytes correlates with strain-specific susceptibility to experimental autoimmune encephalomyelitis.

Authors:  P T Massa; V ter Meulen; A Fontana
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

9.  Cytotoxicity of tumor necrosis factor for thyroid epithelial cells and its regulation by interferon-gamma.

Authors:  J Taverne; D C Rayner; P H Van der Meide; P M Lydyard; S P Bidey; A Cooke
Journal:  Eur J Immunol       Date:  1987-12       Impact factor: 5.532

10.  Genetic factors controlling the susceptibility to experimental autoimmune thyroiditis in inbred rat strains.

Authors:  H S Lillehoj; K Beisel; N R Rose
Journal:  J Immunol       Date:  1981-08       Impact factor: 5.422
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  1 in total

Review 1.  Autoantigens in thyroid diseases.

Authors:  K Dawe; P Hutchings; B Champion; A Cooke; I Roitt
Journal:  Springer Semin Immunopathol       Date:  1993
  1 in total

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