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Literature DB >> 26490988

The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration.

Jianjun Bi^1,2, Peng Li^1,2, Chuanyin Li^3,4,5, Jie He¹, Ying Wang^1,2, He Zhang^1,2, Xianqun Fan¹, Renbing Jia⁶, Shengfang Ge^7,8.

Abstract

The stromal-cell-derived factor 1 (SDF-1)/chemokine receptor 4 (CXCR4) chemokine axis plays a key role in tumor migration. Here, we analyzed the axis in uveal melanoma (UM) proliferation and migration and investigated the effect of a chemical inhibitor of CXCR4, AMD3100, on UM. We found that CXCR4 was expressed in all five UM cell lines tested as well as the retinal pigment epithelium cell line ARPE-19 cells, while CXCR7 was only detected in OM290 and VUP cell lines. SDF-1 promotes the proliferation and migration of OCM-1 and OCM431 cell lines, while AMD3100 weakens this function. Taken together, our results show that the SDF-1/CXCR4 chemokine axis plays a key role in UM cell proliferation and migration and that AMD3100 can alleviate this function, which may offer a hint for UM treatment.

Entities: Disease Gene Species

Keywords: AMD3100; Migration; SDF1/CXCR4; Uveal melanoma

Mesh：

Substances：

Year: 2015 PMID： 26490988 DOI： 10.1007/s13277-015-4259-4

Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283

31 in total

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Review 3. Epithelial-mesenchymal transitions in development and disease.

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Review 4. Role of chemokines in renal cell carcinoma.

Authors: Jaspreet S Parihar; Hari S G R Tunuguntla
Journal: Rev Urol Date: 2014

5. Effects of inhibition of hedgehog signaling on cell growth and migration of uveal melanoma cells.

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6. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature.

Authors: Zhenhua Miao; Kathryn E Luker; Bretton C Summers; Rob Berahovich; Mahaveer S Bhojani; Alnawaz Rehemtulla; Celina G Kleer; Jeffrey J Essner; Aidas Nasevicius; Gary D Luker; Maureen C Howard; Thomas J Schall
Journal: Proc Natl Acad Sci U S A Date: 2007-09-26 Impact factor: 11.205

Review 7. Clonal diversity in carcinomas: its implications for tumour progression and the contribution made to it by epithelial-mesenchymal transitions.

Authors: J Guy Lyons; Erwin Lobo; Anna M Martorana; Mary R Myerscough
Journal: Clin Exp Metastasis Date: 2007-12-11 Impact factor: 5.150

8. CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type.

Authors: Stefania Scala; Caterina Ieranò; Alessandro Ottaiano; Renato Franco; Anna La Mura; Giuseppina Liguori; Massimo Mascolo; Stefania Staibano; Paolo A Ascierto; Gerardo Botti; Gaetano De Rosa; Giuseppe Castello
Journal: Cancer Immunol Immunother Date: 2007-04-05 Impact factor: 6.968

Review 9. Dissemination and growth of cancer cells in metastatic sites.

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Journal: Nat Rev Cancer Date: 2002-08 Impact factor: 60.716

10. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.

Authors: Jennifer M Burns; Bretton C Summers; Yu Wang; Anita Melikian; Rob Berahovich; Zhenhua Miao; Mark E T Penfold; Mary Jean Sunshine; Dan R Littman; Calvin J Kuo; Kevin Wei; Brian E McMaster; Kim Wright; Maureen C Howard; Thomas J Schall
Journal: J Exp Med Date: 2006-08-28 Impact factor: 14.307

6 in total

1. Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 and Reduces Primary Tumor Growth and Metastasis of Uveal Melanoma.

Authors: Lei Dong; Shuo You; Qing Zhang; Satoru Osuka; Narra S Devi; Stefan Kaluz; Jalisa H Ferguson; Hua Yang; Guoliang Chen; Binghe Wang; Hans E Grossniklaus; Erwin G Van Meir
Journal: Clin Cancer Res Date: 2018-12-18 Impact factor: 12.531

2. Tenascin‑C promotes the migration of bone marrow stem cells via toll‑like receptor 4‑mediated signaling pathways: MAPK, AKT and Wnt.

Authors: Huaiyu Ding; Mingyu Jin; Dai Liu; Shujing Wang; Jianing Zhang; Xiantao Song; Rongchong Huang
Journal: Mol Med Rep Date: 2018-04-05 Impact factor: 2.952