Literature DB >> 26490952

Genome-wide association studies in pediatric chronic kidney disease.

Jayanta Gupta1, Peter A Kanetsky2, Matthias Wuttke3, Anna Köttgen3, Franz Schaefer4, Craig S Wong5.   

Abstract

The genome-wide association study (GWAS) has become an established scientific method that provides an unbiased screen for genetic loci potentially associated with phenotypes of clinical interest, such as chronic kidney disease (CKD). Thus, GWAS provides opportunities to gain new perspectives regarding the genetic architecture of CKD progression by identifying new candidate genes and targets for intervention. As such, it has become an important arm of translational science providing a complementary line of investigation to identify novel therapeutics to treat CKD. In this review, we describe the method and the challenges of performing GWAS in the pediatric CKD population. We also provide an overview of successful GWAS for kidney disease, and we discuss the established pediatric CKD cohorts in North America and Europe that are poised to identify genetic risk variants associated with CKD progression.

Entities:  

Keywords:  Chronic kidney disease; Genetics; Genome-wide association study (GWAS); Pediatric; Translational medicine

Mesh：

Year:  2015        PMID： 26490952      PMCID： PMC5287054          DOI： 10.1007/s00467-015-3235-y

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  53 in total

1.  The APOL1 gene and allograft survival after kidney transplantation.

Authors:  A M Reeves-Daniel; J A DePalma; A J Bleyer; M V Rocco; M Murea; P L Adams; C D Langefeld; D W Bowden; P J Hicks; R J Stratta; J-J Lin; D F Kiger; M D Gautreaux; J Divers; B I Freedman
Journal:  Am J Transplant       Date:  2011-04-12       Impact factor: 8.086

2.  Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy.

Authors:  Atsuyuki Shimazaki; Yoshihiro Kawamura; Akio Kanazawa; Akihiro Sekine; Susumu Saito; Tatsuhiko Tsunoda; Daisuke Koya; Tetsuya Babazono; Yasushi Tanaka; Masafumi Matsuda; Koichi Kawai; Tomohiro Iiizumi; Masahito Imanishi; Toshihiro Shinosaki; Toru Yanagimoto; Minoru Ikeda; Shigeki Omachi; Atsunori Kashiwagi; Kohei Kaku; Yasuhiko Iwamoto; Ryuzou Kawamori; Ryuichi Kikkawa; Masatoshi Nakajima; Yusuke Nakamura; Shiro Maeda
Journal:  Diabetes       Date:  2005-04       Impact factor: 9.461

3.  Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.

Authors:  Matthias Wuttke; Craig S Wong; Elke Wühl; Daniel Epting; Li Luo; Anselm Hoppmann; Anke Doyon; Yong Li; Betül Sözeri; Daniela Thurn; Martin Helmstädter; Tobias B Huber; Tom D Blydt-Hansen; Albrecht Kramer-Zucker; Otto Mehls; Anette Melk; Uwe Querfeld; Susan L Furth; Bradley A Warady; Franz Schaefer; Anna Köttgen
Journal:  Nephrol Dial Transplant       Date:  2015-09-28       Impact factor: 5.992

Review 4.  Progression in chronic kidney disease.

Authors:  Allison A Eddy
Journal:  Adv Chronic Kidney Dis       Date:  2005-10       Impact factor: 3.620

5.  Predictors of Rapid Progression of Glomerular and Nonglomerular Kidney Disease in Children and Adolescents: The Chronic Kidney Disease in Children (CKiD) Cohort.

Authors:  Bradley A Warady; Alison G Abraham; George J Schwartz; Craig S Wong; Alvaro Muñoz; Aisha Betoko; Mark Mitsnefes; Frederick Kaskel; Larry A Greenbaum; Robert H Mak; Joseph Flynn; Marva M Moxey-Mims; Susan Furth
Journal:  Am J Kidney Dis       Date:  2015-03-19       Impact factor: 8.860

6.  Metabolic abnormalities, cardiovascular disease risk factors, and GFR decline in children with chronic kidney disease.

Authors:  Susan L Furth; Alison G Abraham; Judith Jerry-Fluker; George J Schwartz; Mark Benfield; Frederick Kaskel; Craig Wong; Robert H Mak; Marva Moxey-Mims; Bradley A Warady
Journal:  Clin J Am Soc Nephrol       Date:  2011-08-12       Impact factor: 8.237

7.  The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival.

Authors:  B T Lee; V Kumar; T A Williams; R Abdi; A Bernhardy; C Dyer; S Conte; G Genovese; M D Ross; D J Friedman; R Gaston; E Milford; M R Pollak; A Chandraker
Journal:  Am J Transplant       Date:  2012-04-04       Impact factor: 8.086

8.  Strict blood-pressure control and progression of renal failure in children.

Authors:  Elke Wühl; Antonella Trivelli; Stefano Picca; Mieczyslaw Litwin; Amira Peco-Antic; Aleksandra Zurowska; Sara Testa; Augustina Jankauskiene; Sevinc Emre; Alberto Caldas-Afonso; Ali Anarat; Patrick Niaudet; Sevgi Mir; Aysin Bakkaloglu; Barbara Enke; Giovanni Montini; Ann-Margret Wingen; Peter Sallay; Nikola Jeck; Ulla Berg; Salim Caliskan; Simone Wygoda; Katharina Hohbach-Hohenfellner; Jiri Dusek; Tomasz Urasinski; Klaus Arbeiter; Thomas Neuhaus; Jutta Gellermann; Dorota Drozdz; Michel Fischbach; Kristina Möller; Marianne Wigger; Licia Peruzzi; Otto Mehls; Franz Schaefer
Journal:  N Engl J Med       Date:  2009-10-22       Impact factor: 91.245

9.  Chronic Renal Insufficiency Cohort (CRIC) Study: baseline characteristics and associations with kidney function.

Authors:  James P Lash; Alan S Go; Lawrence J Appel; Jiang He; Akinlolu Ojo; Mahboob Rahman; Raymond R Townsend; Dawei Xie; Denise Cifelli; Janet Cohan; Jeffrey C Fink; Michael J Fischer; Crystal Gadegbeku; L Lee Hamm; John W Kusek; J Richard Landis; Andrew Narva; Nancy Robinson; Valerie Teal; Harold I Feldman
Journal:  Clin J Am Soc Nephrol       Date:  2009-06-18       Impact factor: 8.237

10.  The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases.

Authors:  Mirko Manchia; Jeffrey Cullis; Gustavo Turecki; Guy A Rouleau; Rudolf Uher; Martin Alda
Journal:  PLoS One       Date:  2013-10-11       Impact factor: 3.240
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  5 in total

Review 1.  The nephrologist of tomorrow: towards a kidney-omic future.

Authors:  Mina H Hanna; Alessandra Dalla Gassa; Gert Mayer; Gianluigi Zaza; Patrick D Brophy; Loreto Gesualdo; Francesco Pesce
Journal:  Pediatr Nephrol       Date:  2016-03-09       Impact factor: 3.714

Review 2.  Genome-wide association studies of albuminuria: towards genetic stratification in diabetes?

Authors:  Cristian Pattaro
Journal:  J Nephrol       Date:  2017-09-16       Impact factor: 3.902

3.  Ethical and Policy Considerations for Genomic Testing in Pediatric Research: The Path Toward Disclosing Individual Research Results.

Authors:  Craig S Wong; Amy J Kogon; Bradley A Warady; Susan L Furth; John D Lantos; Benjamin S Wilfond
Journal:  Am J Kidney Dis       Date:  2019-03-14       Impact factor: 8.860

4.  Genetic, Environmental, and Disease-Associated Correlates of Vitamin D Status in Children with CKD.

Authors:  Anke Doyon; Bettina Schmiedchen; Anja Sander; Aysun Bayazit; Ali Duzova; Nur Canpolat; Daniela Thurn; Karolis Azukaitis; Ali Anarat; Justine Bacchetta; Sevgi Mir; Rukshana Shroff; Ebru Yilmaz; Cengiz Candan; Markus Kemper; Michel Fischbach; Gerard Cortina; Günter Klaus; Matthias Wuttke; Anna Köttgen; Anette Melk; Uwe Querfeld; Franz Schaefer
Journal:  Clin J Am Soc Nephrol       Date:  2016-06-16       Impact factor: 8.237

5.  Chronic kidney disease in children.

Authors:  Francesca Becherucci; Rosa Maria Roperto; Marco Materassi; Paola Romagnani
Journal:  Clin Kidney J       Date:  2016-06-05
  5 in total

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