Fernando Guerrero-Romero1, Martha Rodríguez-Morán2, Gabriela Hernández-Ronquillo3, Rita Gómez-Díaz4, María L Pizano-Zarate5, Niels H Wacher6, Rafael Mondragón-González6, Luis E Simental-Mendia1. 1. Biomedical Research Unit of the Mexican Social Security Institute at Durango, Mexico; Research Group on Diabetes and Chronic Illnesses at Durango, Mexico. 2. Research Group on Diabetes and Chronic Illnesses at Durango, Mexico. Electronic address: rodriguez.moran.martha@gmail.com. 3. Biomedical Research Unit of the Mexican Social Security Institute at Durango, Mexico. 4. National Institute of Perinatology from Mexico, Mexico; High Specialty Medical Unit, Specialty Hospital, National Medical Center Century XXI, Mexican Social Security Institute, Mexico. 5. National Institute of Perinatology from Mexico, Mexico; Family Medicine Unit 4, Mexican Social Security Institute, Mexico. 6. Research Unit in Clinic Epidemiology, High Specialty Medical Unit, Specialty Hospital, National Medical Center Century XXI, Mexico.
Abstract
OBJECTIVE: To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children. STUDY DESIGN: A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years. RESULTS: The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P < .0005; 11-15 years: OR, 1.38, P = .018) and hypertension (6-10 years: OR, 4.87, P < .0005; 11-15 years: OR, 1.83, P = .0002). CONCLUSION: Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.
OBJECTIVE: To evaluate the association of hypomagnesemia with prehypertension (preHTN) and hypertension in children. STUDY DESIGN: A total of 3954 apparently healthy Mexican children were enrolled in a cross-sectional study. Exclusion criteria were type 2 diabetes; hepatic, renal, or endocrine disease; impaired fasting glucose; chronic diarrhea; and intake of vitamins or magnesium supplements in the previous 6 months. preHTN was defined by systolic and/or diastolic blood pressure ≥90th to <95th percentile and hypertension by systolic and/or diastolic blood pressure ≥95th percentile, according to age, sex, and height percentile. Hypomagnesemia was defined by serum magnesium concentration <1.8 mg/dL (<0.74 mmol/L). To control for potential sources of bias related to age, participants were allocated into 2 groups, aged 6-10 years and 11-15 years. RESULTS: The prevalence of preHTN and hypertension was 12.2% and 6.4%, respectively, in children aged 6-10 years and 13.9% and 10.6% in those aged 11-15 years. Hypomagnesemia was identified in 59 children with preHTN (27.3%) and 52 (45.6%) with hypertension in the 6-10 year age group, and in 115 children with preHTN (36.0%) and 109 (49.6%) with hypertension in the 11-15 year age group. Adjusted multiple logistic regression analysis showed that in children in both age groups, hypomagnesemia was associated with both preHTN (6-10 years: OR, 2.18, P < .0005; 11-15 years: OR, 1.38, P = .018) and hypertension (6-10 years: OR, 4.87, P < .0005; 11-15 years: OR, 1.83, P = .0002). CONCLUSION: Our results indicate that serum magnesium level <1.8 mg/dL is significantly associated with preHTN and hypertension in apparently healthy children.
Authors: Mingzhu Nie; Manjot S Bal; Jie Liu; Zhufeng Yang; Carolina Rivera; Xue-Ru Wu; Joost G J Hoenderop; René J M Bindels; Denise K Marciano; Matthias T F Wolf Journal: J Biol Chem Date: 2018-08-23 Impact factor: 5.157
Authors: Luis E Simental-Mendía; Gabriela Hernández-Ronquillo; Rita Gómez-Díaz; Martha Rodríguez-Morán; Fernando Guerrero-Romero Journal: Pediatr Res Date: 2017-08-30 Impact factor: 3.756
Authors: IfeanyiChukwu O Onor; Emily K Johnston; Nicole G Little; Lashira M Hill; Oluwabunmi E Lawal; Casey J Payne; Mallory R Coleman; Carolkim H Huynh; Sarah E Bilbe; Ahlam A Ayyad; Kabrea J Jones; Jasmine D Kinnard; Rosanna Dastoori; Devinn K Rolland; Amanda S Miller; Robbie A Beyl; Christopher J Gillard; John I Okogbaa; Daniel F Sarpong; Rim M Hadgu; Amne Borghol; Samuel C Okpechi; Mihran V Naljayan; Shane E Sanne; Shane G Guillory Journal: J Clin Hypertens (Greenwich) Date: 2021-05-08 Impact factor: 3.738