Cindy Jauhrur Chan1,2, Guangyong Zou1,3, Samuel Wiebe4, Kathy Nixon Speechley1,2,5. 1. Department of Epidemiology & Biostatistics, Western University, London, Ontario, Canada. 2. Children's Health Research Institute, Lawson Health Research Institute, London, Ontario, Canada. 3. Robarts Research Institute, Western University, London, Ontario, Canada. 4. Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada. 5. Department of Paediatrics, Western University, London, Ontario, Canada.
Abstract
OBJECTIVE: The Global Assessment of Severity of Epilepsy (GASE) Scale is a single-item, 7-point global rating scale designed for neurologist-report of overall severity of epilepsy in children. Building on previous preliminary evidence of its validity and reliability for research and clinical use, this study evaluated the GASE Scale's construct validity, reliability, and responsiveness to changes in severity of epilepsy. METHODS: Data used for the study arose from the Health-Related Quality of Life in Children with Epilepsy Study (HERQULES), a 2-year multicenter prospective cohort study (n = 374) with observations taken at baseline, and 6, 12, and 24 months after diagnosis. Construct validity and reliability were quantified using Spearman's correlation and intraclass correlation coefficient (ICC). Responsiveness was assessed using both distribution-based and anchor-based indices. RESULTS: The GASE Scale was at least moderately correlated (r ≥ 0.30) with several key clinical aspects and most strongly correlated with frequency and intensity of seizures and interference of epilepsy or drugs with daily activities (r > 0.30). Total variation in GASE Scale scores explained by seven core clinical aspects of epilepsy increased over time (R(2) = 28% at baseline to R(2) = 70% at 24 months). The GASE Scale had modest test-retest reliability (ICC range: 0.52-0.64) and was responsive to changes in clinical criteria (standardized response mean range: 0.49-0.68; probability of change range: 0.69-0.75; Guyatt's responsiveness statistic range: 0.56-0.84). The GASE Scale showed potential to discriminate "stable" and "changed" patients according to select criteria and to a composite score (area under the receiver operating characteristic [ROC] curve range: 0.50-0.67). SIGNIFICANCE: Results offer additional evidence in support of the GASE Scale's validity, reliability, as well as responsiveness to changes in severity of epilepsy in children. We conclude that the GASE Scale is a potentially useful tool for assessing the severity of epilepsy in both clinical and research settings. Wiley Periodicals, Inc.
OBJECTIVE: The Global Assessment of Severity of Epilepsy (GASE) Scale is a single-item, 7-point global rating scale designed for neurologist-report of overall severity of epilepsy in children. Building on previous preliminary evidence of its validity and reliability for research and clinical use, this study evaluated the GASE Scale's construct validity, reliability, and responsiveness to changes in severity of epilepsy. METHODS: Data used for the study arose from the Health-Related Quality of Life in Children with Epilepsy Study (HERQULES), a 2-year multicenter prospective cohort study (n = 374) with observations taken at baseline, and 6, 12, and 24 months after diagnosis. Construct validity and reliability were quantified using Spearman's correlation and intraclass correlation coefficient (ICC). Responsiveness was assessed using both distribution-based and anchor-based indices. RESULTS: The GASE Scale was at least moderately correlated (r ≥ 0.30) with several key clinical aspects and most strongly correlated with frequency and intensity of seizures and interference of epilepsy or drugs with daily activities (r > 0.30). Total variation in GASE Scale scores explained by seven core clinical aspects of epilepsy increased over time (R(2) = 28% at baseline to R(2) = 70% at 24 months). The GASE Scale had modest test-retest reliability (ICC range: 0.52-0.64) and was responsive to changes in clinical criteria (standardized response mean range: 0.49-0.68; probability of change range: 0.69-0.75; Guyatt's responsiveness statistic range: 0.56-0.84). The GASE Scale showed potential to discriminate "stable" and "changed" patients according to select criteria and to a composite score (area under the receiver operating characteristic [ROC] curve range: 0.50-0.67). SIGNIFICANCE: Results offer additional evidence in support of the GASE Scale's validity, reliability, as well as responsiveness to changes in severity of epilepsy in children. We conclude that the GASE Scale is a potentially useful tool for assessing the severity of epilepsy in both clinical and research settings. Wiley Periodicals, Inc.
Authors: Avani C Modi; Anup D Patel; Ana M Gutierrez-Colina; Sara E Wetter; Leah M Heckaman; Andrea Debs; Constance A Mara; Evelynne Wentzel; Matthew Schmidt; Jack Stevens Journal: Epilepsy Behav Date: 2020-12-09 Impact factor: 2.937
Authors: Anne T Berg; Karen Kaiser; Tracy Dixon-Salazar; Andi Elliot; Nancy McNamara; Mary Anne Meskis; Emily Golbeck; Priya Tatachar; Linda Laux; Carrie Raia; Janice Stanley; April Luna; Christian Rozek Journal: Epilepsia Open Date: 2019-04-14
Authors: Klajdi Puka; Karen Bax; Andrea Andrade; Margo Devries-Rizzo; Hema Gangam; Simon Levin; Maryam N Nouri; Asuri N Prasad; Mary Secco; Guangyong Zou; Kathy N Speechley Journal: Trials Date: 2020-11-11 Impact factor: 2.279