Georgia Kourlaba1, John Relakis2, Stathis Kontodimas3, Majbrit V Holm4, Nikos Maniadakis5. 1. The Stavros Niarchos Foundation-Collaborative Center for Clinical Epidemiology and Outcomes Research, National and Kapodistrian University of Athens School of Medicine, Athens, Greece. 2. Department of Health Services Organization and Management, National School of Public Health, Athens, Greece. Electronic address: jrelakis@gmail.com. 3. Corporate Affairs & Market Access, LEO Pharmaceutical Products Hellas S.A., Athens, Greece. 4. Patient Access, Global Patient Solutions Thrombosis, LEO Pharma A/S, Ballerup, Denmark. 5. Department of Health Services Organization and Management, National School of Public Health, Athens, Greece.
Abstract
BACKGROUND: Pregnancy-related venous thromboembolism (VTE) is one of the leading causes of maternal morbidity and mortality. OBJECTIVES: To review the epidemiology, and humanistic and economic burden of pregnancy-related VTE. SEARCH STRATEGY: Medline, the Cochrane Central Register of Controlled Trials, Econlit, Science Direct, JSTOR, Oxford Journals, and Cambridge Journals were searched for reports published between January 2000 and December 2012. Keywords related to VTE, pregnancy, and epidemiology and the humanistic and economic burdens were combined. SELECTION CRITERIA: Eligible studies evaluated the incidence, mortality, recurrence, complications, quality-of-life, and economic burden of VTE among pregnant women, and had been published in English. DATA COLLECTION AND ANALYSIS: Background information of the study, participants' characteristics, and study outcomes were collected. Meta-analyses of data were performed. MAIN RESULTS: Twenty studies were included, none of which investigated the economic burden. The pooled overall incidence of pregnancy-related VTE was 1.2 per 1000 deliveries. The pooled VTE case fatality rate was 0.68% and the recurrence rate was 4.27%. The pooled risk of major bleeding was 1.05%. Post-thrombotic syndrome seemed to have a negative effect on quality of life. CONCLUSIONS: Although the incidence of VTE was found to be relatively low during pregnancy and the postpartum period, the clinical burden is high. Further research is required to assess the economic burden of pregnancy-relate VTE.
BACKGROUND: Pregnancy-related venous thromboembolism (VTE) is one of the leading causes of maternal morbidity and mortality. OBJECTIVES: To review the epidemiology, and humanistic and economic burden of pregnancy-related VTE. SEARCH STRATEGY: Medline, the Cochrane Central Register of Controlled Trials, Econlit, Science Direct, JSTOR, Oxford Journals, and Cambridge Journals were searched for reports published between January 2000 and December 2012. Keywords related to VTE, pregnancy, and epidemiology and the humanistic and economic burdens were combined. SELECTION CRITERIA: Eligible studies evaluated the incidence, mortality, recurrence, complications, quality-of-life, and economic burden of VTE among pregnant women, and had been published in English. DATA COLLECTION AND ANALYSIS: Background information of the study, participants' characteristics, and study outcomes were collected. Meta-analyses of data were performed. MAIN RESULTS: Twenty studies were included, none of which investigated the economic burden. The pooled overall incidence of pregnancy-related VTE was 1.2 per 1000 deliveries. The pooled VTE case fatality rate was 0.68% and the recurrence rate was 4.27%. The pooled risk of major bleeding was 1.05%. Post-thrombotic syndrome seemed to have a negative effect on quality of life. CONCLUSIONS: Although the incidence of VTE was found to be relatively low during pregnancy and the postpartum period, the clinical burden is high. Further research is required to assess the economic burden of pregnancy-relate VTE.
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Authors: Claudia Mac Donald Bley Nascimento; Andréa Maria Novaes Machado; João Carlos de Campos Guerra; Eduardo Zlotnik; Dirceu Hamilton Cordeiro Campêlo; Paulo Kauffman; Hilton Waksman; Nelson Wolosker; Sérgio Podgaec; Nelson Hamerschlak Journal: Einstein (Sao Paulo) Date: 2019-08-19
Authors: Celestin Danwang; Mazou N Temgoua; Valirie Ndip Agbor; Aurel T Tankeu; Jean Jacques Noubiap Journal: BMJ Open Date: 2017-10-10 Impact factor: 2.692