Literature DB >> 26486103

microRNA deregulation in keloids: an opportunity for clinical intervention?

Xin Yu1, Zheng Li2, Matthew T V Chan3, William K K Wu3,4.   

Abstract

Keloids are defined as benign dermal scars invading adjacent healthy tissue, characterized by aberrant fibroblast dynamics and overproduction of extracellular matrix. However, the aetiology and molecular mechanism of keloid production remain poorly understood. Recent discoveries have shed new light on the involvement of a class of non-coding RNAs known as microRNAs (miRNA), in keloid formation. A number of miRNAs have differential expression in keloid tissues and keloid-derived fibroblasts. These miRNAs have been characterized as novel regulators of cellular processes pertinent to wound healing, including extracellular matrix deposition and fibroblast proliferation. Delineating the functional significance of miRNA deregulation may help us better understand pathogenesis of keloids, and promote development of miRNA-directed therapeutics against this condition.
© 2015 John Wiley & Sons Ltd.

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Year:  2015        PMID： 26486103      PMCID： PMC6496423          DOI： 10.1111/cpr.12225

Source DB:  PubMed          Journal:  Cell Prolif        ISSN： 0960-7722            Impact factor:   6.831


  72 in total

Review 1.  New insights on keloids, hypertrophic scars, and striae.

Authors:  Sara Ud-Din; Ardeshir Bayat
Journal:  Dermatol Clin       Date:  2014-04       Impact factor: 3.478

2.  MicroRNA-31 Promotes Skin Wound Healing by Enhancing Keratinocyte Proliferation and Migration.

Authors:  Dongqing Li; X I Li; Aoxue Wang; Florian Meisgen; Andor Pivarcsi; Enikö Sonkoly; Mona Ståhle; Ning Xu Landén
Journal:  J Invest Dermatol       Date:  2015-02-16       Impact factor: 8.551

3.  MiRNA expression signature for potentially predicting the prognosis of ovarian serous carcinoma.

Authors:  Xiaotang Yu; Xinchen Zhang; Tie Bi; Yanfang Ding; Jinyao Zhao; Chang Wang; Tingting Jia; Dan Han; Gordon Guo; Bo Wang; Jiyong Jiang; Shiying Cui
Journal:  Tumour Biol       Date:  2013-07-09

4.  Combined treatment of earlobe keloids with shaving, cryosurgery, and intralesional steroid injection: a 1-year follow-up.

Authors:  Mariana Figueiroa Careta; Ana C Fortes; Maria Cristina Messina; Celina W Maruta
Journal:  Dermatol Surg       Date:  2013-02-04       Impact factor: 3.398

5.  MiR-7, inhibited indirectly by lincRNA HOTAIR, directly inhibits SETDB1 and reverses the EMT of breast cancer stem cells by downregulating the STAT3 pathway.

Authors:  Hongyi Zhang; Kai Cai; Jing Wang; Xiaoying Wang; Kai Cheng; Fangfang Shi; Longwei Jiang; Yunxia Zhang; Jun Dou
Journal:  Stem Cells       Date:  2014-11       Impact factor: 6.277

6.  Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro.

Authors:  Ping Li; Quan-Yong He; Cheng-Qun Luo
Journal:  J Dermatol       Date:  2014-09-16       Impact factor: 4.005

7.  MicroRNA-135a acts as a putative tumor suppressor by directly targeting very low density lipoprotein receptor in human gallbladder cancer.

Authors:  Huading Zhou; Weijie Guo; Yingjun Zhao; Yifei Wang; Ruopeng Zha; Jie Ding; Linhui Liang; Guanghua Yang; Zongyou Chen; Baojin Ma; Baobing Yin
Journal:  Cancer Sci       Date:  2014-08       Impact factor: 6.716

8.  MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN.

Authors:  Li-Juan Wang; Chen-Chen He; Xin Sui; Meng-Jiao Cai; Cong-Ya Zhou; Jin-Lu Ma; Lei Wu; Hao Wang; Su-Xia Han; Qing Zhu
Journal:  Oncotarget       Date:  2015-03-20

9.  Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway.

Authors:  Huanxin Liu; Jie Huang; Juan Peng; Xiaoxia Wu; Yan Zhang; Weiliang Zhu; Linlang Guo
Journal:  Mol Cancer       Date:  2015-03-12       Impact factor: 27.401

10.  miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer.

Authors:  S-F Su; Y-W Chang; C Andreu-Vieyra; J Y Fang; Z Yang; B Han; A S Lee; G Liang
Journal:  Oncogene       Date:  2012-10-22       Impact factor: 9.867
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  17 in total

1.  miR-1297 regulates neural stem cell differentiation and viability through controlling Hes1 expression.

Authors:  Jiaolin Zheng; Dan Yi; Xiaodong Shi; Huaizhang Shi
Journal:  Cell Prolif       Date:  2017-05-02       Impact factor: 6.831

Review 2.  From genetics to epigenetics: new insights into keloid scarring.

Authors:  Yongjing He; Zhenjun Deng; Mansour Alghamdi; Lechun Lu; Mark W Fear; Li He
Journal:  Cell Prolif       Date:  2017-01-05       Impact factor: 6.831

Review 3.  Noncoding RNAs in Wound Healing: A New and Vast Frontier.

Authors:  Anna Luan; Michael S Hu; Tripp Leavitt; Elizabeth A Brett; Kevin C Wang; Michael T Longaker; Derrick C Wan
Journal:  Adv Wound Care (New Rochelle)       Date:  2018-01-01       Impact factor: 4.730

4.  MiR-330-3p inhibits gastric cancer progression through targeting MSI1.

Authors:  Aoran Guan; Hui Wang; Xun Li; Hui Xie; Ruotian Wang; Yankun Zhu; Ruhong Li
Journal:  Am J Transl Res       Date:  2016-11-15       Impact factor: 4.060

5.  LINC00937 suppresses keloid fibroblast proliferation and extracellular matrix deposition by targeting the miR-28-5p/MC1R axis.

Authors:  Jing Wan; Xiao-Lei He; Qi-Chao Jian; Zhi-Feng Fan; Ying Shi; Long-Fei Luo
Journal:  Histol Histopathol       Date:  2021-08-23       Impact factor: 2.303

6.  miR-320 inhibited ovarian cancer oncogenicity via targeting TWIST1 expression.

Authors:  Chunyang Li; Ping Duan; Jianguang Wang; Xiaosheng Lu; Jing Cheng
Journal:  Am J Transl Res       Date:  2017-08-15       Impact factor: 4.060

Review 7.  The role of microRNAs in the adrenocortical carcinomas.

Authors:  Xin Yu; Zheng Li
Journal:  Tumour Biol       Date:  2015-12-15

8.  Blockade of LINC01605-enriched exosome generation in M2 macrophages impairs M2 macrophage-induced proliferation, migration, and invasion of human dermal fibroblasts.

Authors:  Zhensen Zhu; Bo Chen; Liang Peng; Songying Gao; Jingdong Guo; Xiongxiang Zhu
Journal:  Int J Immunopathol Pharmacol       Date:  2021 Jan-Dec       Impact factor: 3.219

9.  MicroRNA-595 sensitizes ovarian cancer cells to cisplatin by targeting ABCB1.

Authors:  Songyu Tian; Mingyue Zhang; Xiuwei Chen; Yunduo Liu; Ge Lou
Journal:  Oncotarget       Date:  2016-12-27

10.  MicroRNA-224 promotes the sensitivity of osteosarcoma cells to cisplatin by targeting Rac1.

Authors:  Shuo Geng; Lina Gu; Fang Ju; Hepeng Zhang; Yiwen Wang; Han Tang; ZhengGang Bi; Chenglin Yang
Journal:  J Cell Mol Med       Date:  2016-05-25       Impact factor: 5.310
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