| Literature DB >> 31129175 |
Irina A Kirpich1, Dennis R Warner2, Wenke Feng3, Swati Joshi-Barve3, Craig J McClain1, Devanshi Seth4, Wei Zhong5, Zhanxiang Zhou5, Natalia A Osna6, Kusum K Kharbanda7.
Abstract
The symposium "Mechanisms, Biomarkers and Targets for Therapy in Alcohol-associated Liver Injury: From Genetics to Nutrition" was held at the 19th Congress of International Society for Biomedical Research on Alcoholism on September 13th, 2018 in Kyoto, Japan. The goal of the symposium was to discuss the importance of genetics and nutrition in alcoholic liver disease (ALD) development from mechanistic and therapeutic perspectives. The following is a summary of this session addressing the gene polymorphisms in ALD, the role of zinc in gut-liver axis perturbations associated with ALD, highlighting the importance of dietary fat in ALD pathogenesis, the hepatic n6 and n3 PUFA oxylipin pattern associated with ethanol-induced liver injury, and finally deliberating on new biomarkers for alcoholic hepatitis and their implications for diagnosis and therapy. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows. Published by Elsevier Inc.Entities:
Keywords: 3-hydroxypropyl-mercapturic acid; Porphyromonas gingivalis; acrolein-adducts; alcoholic liver disease; defensin 5; genetic mutations; lipid droplets; oxylipins; perilipins; phosphatidylcholine; phosphatidylethanolamine; resolvins; zinc; zinc transporter
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Year: 2019 PMID： 31129175 PMCID： PMC7043088 DOI： 10.1016/j.alcohol.2019.05.004
Source DB: PubMed Journal: Alcohol ISSN： 0741-8329 Impact factor: 2.405