| Literature DB >> 26482270 |
V Strenger1, S Kayser2, K-E Witte2, D Lassner3, W Schwinger4, G Jahn5, C Urban4, T Feuchtinger6.
Abstract
To evaluate the human herpes virus 6 (HHV-6) -specific immune response in individuals with chromosomally integrated HHV-6 (ciHHV-6), we measured HHV-6-antigen-specific cytokine responses (interferon-γ, interleukin-2, tumour necrosis factor-α) in T cells by flow cytometry in 12 and 16 individuals with and without ciHHV-6, respectively. All individuals with ciHHV-6 showed HHV-6-specific T cells with higher frequencies of HHV-6-specific CD8(+) cells (0.03-14.93, median 2.15% of CD8(+) cells) compared with non-ciHHV-6 (0.0-10.67, median 0.36%, p 0.026). The observed increased HHV-6-specific functionally active responses in individuals with ciHHV-6 clearly disprove speculations on immune tolerance in ciHHV-6 and indicate clinical and immunological implications of ciHHV-6.Entities:
Keywords: Chromosomal integration; HHV-6; T-cell response; U54; cytomegalovirus
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Year: 2015 PMID： 26482270 DOI： 10.1016/j.cmi.2015.10.006
Source DB: PubMed Journal: Clin Microbiol Infect ISSN： 1198-743X Impact factor: 8.067