Literature DB >> 26481307

An agonist antibody that blocks autoimmunity by inducing anti-inflammatory macrophages.

Kyung Ho Han1, Rosana Gonzalez-Quintial1, Yingjie Peng1, Roberto Baccala1, Argyrios N Theofilopoulos1, Richard A Lerner2.   

Abstract

We have devised a method of using intracellular combinatorial libraries to select antibodies that control cell fates. Many agonist antibodies have been selected with this method, and the process appears to be limited only by the availability of a phenotypic selection system. We demonstrate the utility of this approach to discover agonist antibodies that engage an unanticipated target and regulate macrophage polarization by selective induction of anti-inflammatory M2 macrophages. This antibody was used therapeutically to block autoimmunity in a classic mouse model of spontaneous systemic lupus erythematosus. © FASEB.

Entities:  

Keywords:  CD14; CTSG; M2 macrophage; cathepsin G

Mesh：

Substances：

Year:  2015        PMID： 26481307      PMCID： PMC6188224          DOI： 10.1096/fj.15-281329

Source DB:  PubMed          Journal:  FASEB J        ISSN： 0892-6638            Impact factor:   5.191


  34 in total

1.  Regulation of transcription factor latency by receptor-activated proteolysis.

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Review 2.  Neutrophil serine proteases: specific regulators of inflammation.

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Journal:  Nat Rev Immunol       Date:  2006-07       Impact factor: 53.106

3.  Converting stem cells to dendritic cells by agonist antibodies from unbiased morphogenic selections.

Authors:  Kyungmoo Yea; Hongkai Zhang; Jia Xie; Teresa M Jones; Guang Yang; Byeong Doo Song; Richard A Lerner
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Review 4.  Macrophage subpopulations in systemic lupus erythematosus.

Authors:  Jacob Orme; Chandra Mohan
Journal:  Discov Med       Date:  2012-02       Impact factor: 2.970

5.  Autocrine signaling based selection of combinatorial antibodies that transdifferentiate human stem cells.

Authors:  Jia Xie; Hongkai Zhang; Kyungmoo Yea; Richard A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  2013-04-23       Impact factor: 11.205

6.  Human neutrophil cathepsin G down-regulates LPS-mediated monocyte activation through CD14 proteolysis.

Authors:  K Le-Barillec; D Pidard; V Balloy; M Chignard
Journal:  J Leukoc Biol       Date:  2000-08       Impact factor: 4.962

7.  Proteolytic activation of the protease-activated receptor (PAR)-2 by the glycosylphosphatidylinositol-anchored serine protease testisin.

Authors:  Kathryn H Driesbaugh; Marguerite S Buzza; Erik W Martin; Gregory D Conway; Joseph P Y Kao; Toni M Antalis
Journal:  J Biol Chem       Date:  2014-12-17       Impact factor: 5.157

8.  Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis.

Authors:  R Watanabe-Fukunaga; C I Brannan; N G Copeland; N A Jenkins; S Nagata
Journal:  Nature       Date:  1992-03-26       Impact factor: 49.962

Review 9.  Leukocyte cell surface proteinases: regulation of expression, functions, and mechanisms of surface localization.

Authors:  Caroline A Owen
Journal:  Int J Biochem Cell Biol       Date:  2008-01-31       Impact factor: 5.085

10.  p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair.

Authors:  Eusebio Perdiguero; Pedro Sousa-Victor; Vanessa Ruiz-Bonilla; Mercè Jardí; Carme Caelles; Antonio L Serrano; Pura Muñoz-Cánoves
Journal:  J Cell Biol       Date:  2011-10-10       Impact factor: 10.539
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  7 in total

1.  The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.

Authors:  Lara Campana; Philip J Starkey Lewis; Antonella Pellicoro; Rebecca L Aucott; Janet Man; Eoghan O'Duibhir; Sarah E Mok; Sofia Ferreira-Gonzalez; Eilidh Livingstone; Stephen N Greenhalgh; Katherine L Hull; Timothy J Kendall; Douglas Vernimmen; Neil C Henderson; Luke Boulter; Christopher D Gregory; Yi Feng; Stephen M Anderton; Stuart J Forbes; John P Iredale
Journal:  J Immunol       Date:  2017-12-20       Impact factor: 5.422

2.  Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β.

Authors:  Kyung Ho Han; Britni M Arlian; Matthew S Macauley; James C Paulson; Richard A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-02       Impact factor: 11.205

3.  Notch signaling triggered via the ligand DLL4 impedes M2 macrophage differentiation and promotes their apoptosis.

Authors:  Sylvain Pagie; Nathalie Gérard; Béatrice Charreau
Journal:  Cell Commun Signal       Date:  2018-01-10       Impact factor: 5.712

4.  Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis.

Authors:  Sunghyun Kang; Hwan-Woo Park; Kyung Ho Han
Journal:  Int J Mol Sci       Date:  2022-07-15       Impact factor: 6.208

5.  GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet's disease.

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Journal:  Arthritis Res Ther       Date:  2018-06-12       Impact factor: 5.156

6.  An agonist antibody prefers relapsed AML for induction of cells that kill each other.

Authors:  Kyungmoo Yea; Teresa M Jones; Dokyung Jung; Sanghee Shin; Britni M Arlian; Kyung Ho Han; Zhao Zha; Minseok S Kim; Yong-Seok Oh; Hongkai Zhang; Richard A Lerner
Journal:  Sci Rep       Date:  2019-03-05       Impact factor: 4.379

7.  Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart.

Authors:  Kyung Ho Han; Britni M Arlian; Chih-Wei Lin; Hyun Yong Jin; Geun-Hyung Kang; Sahmin Lee; Peter Chang-Whan Lee; Richard A Lerner
Journal:  Cells       Date:  2020-01-20       Impact factor: 6.600
  7 in total

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