Literature DB >> 26479440

Chemical libraries: How dark is HTS dark matter?

Ricardo Macarron1.   

Abstract

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Year:  2015        PMID： 26479440     DOI： 10.1038/nchembio.1937

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


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  4 in total

Review 1.  The influence of drug-like concepts on decision-making in medicinal chemistry.

Authors:  Paul D Leeson; Brian Springthorpe
Journal:  Nat Rev Drug Discov       Date:  2007-11       Impact factor: 84.694

2.  Estimation of the size of drug-like chemical space based on GDB-17 data.

Authors:  P G Polishchuk; T I Madzhidov; A Varnek
Journal:  J Comput Aided Mol Des       Date:  2013-08-21       Impact factor: 3.686

3.  New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays.

Authors:  Jonathan B Baell; Georgina A Holloway
Journal:  J Med Chem       Date:  2010-04-08       Impact factor: 7.446

Review 4.  Rational methods for the selection of diverse screening compounds.

Authors:  David J Huggins; Ashok R Venkitaraman; David R Spring
Journal:  ACS Chem Biol       Date:  2011-02-15       Impact factor: 5.100
  4 in total
  3 in total

1.  "Molecular Anatomy": a new multi-dimensional hierarchical scaffold analysis tool.

Authors:  Candida Manelfi; Marica Gemei; Carmine Talarico; Carmen Cerchia; Anna Fava; Filippo Lunghini; Andrea Rosario Beccari
Journal:  J Cheminform       Date:  2021-07-23       Impact factor: 5.514

2.  Predicted Biological Activity of Purchasable Chemical Space.

Authors:  John J Irwin; Garrett Gaskins; Teague Sterling; Michael M Mysinger; Michael J Keiser
Journal:  J Chem Inf Model       Date:  2017-12-29       Impact factor: 4.956

3.  Molecular Connectivity Predefines Polypharmacology: Aliphatic Rings, Chirality, and sp3 Centers Enhance Target Selectivity.

Authors:  Stefania Monteleone; Julian E Fuchs; Klaus R Liedl
Journal:  Front Pharmacol       Date:  2017-08-28       Impact factor: 5.810
  3 in total

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