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Literature DB >> 26479197

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis.

Malik Chaker-Margot^1,2, Mirjam Hunziker¹, Jonas Barandun¹, Brian D Dill³, Sebastian Klinge¹.

Abstract

Eukaryotic ribosome biogenesis involves a plethora of ribosome-assembly factors, and their temporal order of association with preribosomal RNA is largely unknown. By using Saccharomyces cerevisiae as a model organism, we developed a system that recapitulates and arrests ribosome assembly at early stages, thus providing in vivo snapshots of nascent preribosomal particles. Here we report the stage-specific order in which 70 ribosome-assembly factors associate with preribosomal RNA domains, thereby forming the 6-MDa small-subunit processome.

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Year: 2015 PMID： 26479197 DOI： 10.1038/nsmb.3111

Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369

35 in total

1. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.

Authors: François Dragon; Jennifer E G Gallagher; Patricia A Compagnone-Post; Brianna M Mitchell; Kara A Porwancher; Karen A Wehner; Steven Wormsley; Robert E Settlage; Jeffrey Shabanowitz; Yvonne Osheim; Ann L Beyer; Donald F Hunt; Susan J Baserga
Journal: Nature Date: 2002-06-09 Impact factor: 49.962

2. The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

Authors: Jorge Pérez-Fernández; Angel Román; Javier De Las Rivas; Xosé R Bustelo; Mercedes Dosil
Journal: Mol Cell Biol Date: 2007-05-21 Impact factor: 4.272

3. Modulation of protein properties in living cells using nanobodies.

Authors: Axel Kirchhofer; Jonas Helma; Katrin Schmidthals; Carina Frauer; Sheng Cui; Annette Karcher; Mireille Pellis; Serge Muyldermans; Corella S Casas-Delucchi; M Cristina Cardoso; Heinrich Leonhardt; Karl-Peter Hopfner; Ulrich Rothbauer
Journal: Nat Struct Mol Biol Date: 2009-12-13 Impact factor: 15.369

4. Mutants of the bacteriophage MS2 coat protein that alter its cooperative binding to RNA.

Authors: K A LeCuyer; L S Behlen; O C Uhlenbeck
Journal: Biochemistry Date: 1995-08-22 Impact factor: 3.162

Review 5. Ribosome biogenesis in the yeast Saccharomyces cerevisiae.

Authors: John L Woolford; Susan J Baserga
Journal: Genetics Date: 2013-11 Impact factor: 4.562

6. Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation.

Authors: T Wiederkehr; R F Prétôt; L Minvielle-Sebastia
Journal: RNA Date: 1998-11 Impact factor: 4.942

7. The initial U3 snoRNA:pre-rRNA base pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing.

Authors: Laura M Dutca; Jennifer E G Gallagher; Susan J Baserga
Journal: Nucleic Acids Res Date: 2011-02-23 Impact factor: 16.971

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis.

1. A large nucleolar U3 ribonucleoprotein required for 18S ribosomal RNA biogenesis.

2. The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

3. Modulation of protein properties in living cells using nanobodies.

4. Mutants of the bacteriophage MS2 coat protein that alter its cooperative binding to RNA.

Review 5. Ribosome biogenesis in the yeast Saccharomyces cerevisiae.

6. Synthetic lethal interactions with conditional poly(A) polymerase alleles identify LCP5, a gene involved in 18S rRNA maturation.

7. The initial U3 snoRNA:pre-rRNA base pairing interaction required for pre-18S rRNA folding revealed by in vivo chemical probing.

8. The nucleolar protein Esf2 interacts directly with the DExD/H box RNA helicase, Dbp8, to stimulate ATP hydrolysis.

9. Nucleolar proteins Bfr2 and Enp2 interact with DEAD-box RNA helicase Dbp4 in two different complexes.

10. Multiple RNA interactions position Mrd1 at the site of the small subunit pseudoknot within the 90S pre-ribosome.

1. Ribosomal 60S-subunit production: the final scene.

2. Transient Protein-RNA Interactions Guide Nascent Ribosomal RNA Folding.

3. Box C/D guide RNAs recognize a maximum of 10 nt of substrates.

4. Structural biology: Moulding the ribosome.

5. The complete structure of the small-subunit processome.

6. 3.2-Å-resolution structure of the 90S preribosome before A1 pre-rRNA cleavage.

7. Ribosome origami.

Review 8. Eukaryotic ribosome assembly, transport and quality control.

9. Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae.

10. Structural and catalytic roles of the human 18S rRNA methyltransferases DIMT1 in ribosome assembly and translation.