J H Kim1, H J Choi2, E J Ku3, A R Hong1, K M Kim4, S W Kim1, N H Cho5, C S Shin6. 1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea. 2. Department of Anatomy, Seoul National University College of Medicine, Seoul, South Korea. 3. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, South Korea. 4. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea. 5. Department of Preventive Medicine, Ajou University School of Medicine, Suwon, South Korea. chnaha@ajou.ac.kr. 6. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea. csshin@snu.ac.kr.
Abstract
SUMMARY: In a prospective community-based cohort study, we investigated the relationship between trabecular bone score (TBS) and regional fat depots in 1474 Korean postmenopausal women. TBS was positively related with subcutaneous fat and negatively related with visceral fat. INTRODUCTION: The effect of fat distribution (visceral/subcutaneous) on bone quality or microarchitecture has rarely been investigated due to measurement difficulty. We aimed to investigate the relationship between TBS reflecting bone microarchitecture and regional fat depots in Korean women. METHODS: Cross-sectional data evaluation was made from subjects participating in an ongoing prospective community-based cohort study since 2001. A total of 1474 postmenopausal women in the Ansung cohort were analyzed. Regional body fat mass, bone mineral density (BMD) at the lumbar spine, and total hip and lumbar spine TBS were measured by dual energy X-ray absorptiometry (DXA). RESULTS: In an age-adjusted partial correlation analysis, TBS was not associated with total fat mass, but negatively associated with trunk fat mass. However, TBS was positively related with leg (r = 0.102, P < 0.05) and gynoid fat mass (r = 0.086, P < 0.05) and negatively related with android fat mass (r = -0.106; P < 0.05). In linear regression models controlling age, BMI, and physical activity, android fat was inversely associated with TBS (β = -0.595, P < 0.001), whereas gynoid fat was positively associated with TBS (β = 0.216, P < 0.001). Lumbar spine and total hip BMDs revealed positive associations with total and all regional fat depots regardless of fat distribution. CONCLUSION: Our findings suggest that relatively large visceral fat and small subcutaneous fat may have a detrimental effect on TBS, a bone microarchitecture index.
SUMMARY: In a prospective community-based cohort study, we investigated the relationship between trabecular bone score (TBS) and regional fat depots in 1474 Korean postmenopausal women. TBS was positively related with subcutaneous fat and negatively related with visceral fat. INTRODUCTION: The effect of fat distribution (visceral/subcutaneous) on bone quality or microarchitecture has rarely been investigated due to measurement difficulty. We aimed to investigate the relationship between TBS reflecting bone microarchitecture and regional fat depots in Korean women. METHODS: Cross-sectional data evaluation was made from subjects participating in an ongoing prospective community-based cohort study since 2001. A total of 1474 postmenopausal women in the Ansung cohort were analyzed. Regional body fat mass, bone mineral density (BMD) at the lumbar spine, and total hip and lumbar spine TBS were measured by dual energy X-ray absorptiometry (DXA). RESULTS: In an age-adjusted partial correlation analysis, TBS was not associated with total fat mass, but negatively associated with trunk fat mass. However, TBS was positively related with leg (r = 0.102, P < 0.05) and gynoid fat mass (r = 0.086, P < 0.05) and negatively related with android fat mass (r = -0.106; P < 0.05). In linear regression models controlling age, BMI, and physical activity, android fat was inversely associated with TBS (β = -0.595, P < 0.001), whereas gynoid fat was positively associated with TBS (β = 0.216, P < 0.001). Lumbar spine and total hip BMDs revealed positive associations with total and all regional fat depots regardless of fat distribution. CONCLUSION: Our findings suggest that relatively large visceral fat and small subcutaneous fat may have a detrimental effect on TBS, a bone microarchitecture index.
Entities:
Keywords:
Android fat; Body fat; Gynoid fat; Trabecular bone score
Authors: C J Kim; K W Oh; E J Rhee; K H Kim; S K Jo; C H Jung; J C Won; C Y Park; W Y Lee; S W Park; S W Kim Journal: Clin Endocrinol (Oxf) Date: 2008-10-20 Impact factor: 3.478
Authors: Alvin C Ng; L Joseph Melton; Elizabeth J Atkinson; Sara J Achenbach; Margaret F Holets; James M Peterson; Sundeep Khosla; Matthew T Drake Journal: Bone Date: 2013-02-18 Impact factor: 4.398
Authors: Barbara Campolina Silva; Stephanie Boutroy; Chiyuan Zhang; Donald Jay McMahon; Bin Zhou; Ji Wang; Julia Udesky; Serge Cremers; Marta Sarquis; Xiang-Dong Edward Guo; Didier Hans; John Paul Bilezikian Journal: J Clin Endocrinol Metab Date: 2013-03-22 Impact factor: 5.958
Authors: Scott M MacKenzie; Shahzya S Huda; Naveed Sattar; Robert Fraser; John M C Connell; Eleanor Davies Journal: Clin Endocrinol (Oxf) Date: 2008-04-10 Impact factor: 3.478
Authors: K O Klein; K A Larmore; E de Lancey; J M Brown; R V Considine; S G Hassink Journal: J Clin Endocrinol Metab Date: 1998-10 Impact factor: 5.958
Authors: Seon Mee Kang; Ji Won Yoon; Hwa Young Ahn; So Yeon Kim; Kyoung Ho Lee; Hayley Shin; Sung Hee Choi; Kyong Soo Park; Hak Chul Jang; Soo Lim Journal: PLoS One Date: 2011-11-11 Impact factor: 3.240
Authors: Lisa Langsetmo; Tien N Vo; Kristine E Ensrud; Brent C Taylor; Peggy M Cawthon; Ann V Schwartz; Douglas C Bauer; Eric S Orwoll; Nancy E Lane; Elizabeth Barrett-Connor; John T Schousboe Journal: J Bone Miner Res Date: 2016-05-27 Impact factor: 6.741
Authors: S Aedo; J E Blümel; R M Carrillo-Larco; M S Vallejo; G Aedo; G G Gómez; I Campodónico Journal: Climacteric Date: 2019-11-18 Impact factor: 3.024