Literature DB >> 26475284

The role of Eph/ephrin molecules in stromal–hematopoietic interactions.

Thao M Nguyen, Agnieszka Arthur, Stan Gronthos.   

Abstract

Bone marrow mesenchymal stromal/stem cells(BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrinligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrintargeted therapeutic strategies that are currently being pursued or various hematotological malignancies.

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Year:  2016        PMID： 26475284     DOI： 10.1007/s12185-015-1886-x

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  79 in total

Review 1.  Mechanisms and functions of Eph and ephrin signalling.

Authors:  Klas Kullander; Rüdiger Klein
Journal:  Nat Rev Mol Cell Biol       Date:  2002-07       Impact factor: 94.444

2.  EphB6 crosslinking results in costimulation of T cells.

Authors:  Hongyu Luo; Guang Yu; Yulian Wu; Jiangping Wu
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808

3.  Thymic alterations in EphA4-deficient mice.

Authors:  Juan J Muñoz; David Alfaro; Javier García-Ceca; Luis M Alonso-C; Eva Jiménez; Agustín Zapata
Journal:  J Immunol       Date:  2006-07-15       Impact factor: 5.422

Review 4.  The Eph family of receptors.

Authors:  E B Pasquale
Journal:  Curr Opin Cell Biol       Date:  1997-10       Impact factor: 8.382

5.  In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis.

Authors:  Gladys Valverde-Franco; Jean-Pierre Pelletier; Hassan Fahmi; David Hum; Koichi Matsuo; Bertrand Lussier; Mohit Kapoor; Johanne Martel-Pelletier
Journal:  Arthritis Rheum       Date:  2012-11

6.  Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis.

Authors:  Chen Zhao; Naoko Irie; Yasunari Takada; Kouji Shimoda; Takeshi Miyamoto; Toru Nishiwaki; Toshio Suda; Koichi Matsuo
Journal:  Cell Metab       Date:  2006-08       Impact factor: 27.287

7.  EphB4 enhances the process of endochondral ossification and inhibits remodeling during bone fracture repair.

Authors:  Agnieszka Arthur; Romana A Panagopoulos; Lachlan Cooper; Danijela Menicanin; Ian H Parkinson; John D Codrington; Kate Vandyke; Andrew C W Zannettino; Simon A Koblar; Natalie A Sims; Koichi Matsuo; Stan Gronthos
Journal:  J Bone Miner Res       Date:  2013-04       Impact factor: 6.741

8.  A stem cell molecular signature.

Authors:  Natalia B Ivanova; John T Dimos; Christoph Schaniel; Jason A Hackney; Kateri A Moore; Ihor R Lemischka
Journal:  Science       Date:  2002-09-12       Impact factor: 47.728

9.  Prospective isolation of mesenchymal stem cells from mouse compact bone.

Authors:  Brenton J Short; Nathalie Brouard; Paul J Simmons
Journal:  Methods Mol Biol       Date:  2009

10.  Human mulipotential mesenchymal/stromal stem cells are derived from a discrete subpopulation of STRO-1bright/CD34 /CD45(-)/glycophorin-A-bone marrow cells.

Authors:  Andrew C W Zannettino; Sharon Paton; Angela Kortesidis; Fiona Khor; Silviu Itescu; Stan Gronthos
Journal:  Haematologica       Date:  2007-12       Impact factor: 9.941
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  9 in total

1.  Guest editorial: Human mesenchymal stromal/stem cell (MSC).

Authors:  Yasuo Miura
Journal:  Int J Hematol       Date:  2015-12-23       Impact factor: 2.490

Review 2.  Ephrin ligands and Eph receptors contribution to hematopoiesis.

Authors:  Giovanna Tosato
Journal:  Cell Mol Life Sci       Date:  2017-06-06       Impact factor: 9.261

3.  Deconstructed Microfluidic Bone Marrow On-A-Chip to Study Normal and Malignant Hemopoietic Cell-Niche Interactions.

Authors:  Julio Aleman; Sunil K George; Samuel Herberg; Mahesh Devarasetty; Christopher D Porada; Aleksander Skardal; Graça Almeida-Porada
Journal:  Small       Date:  2019-08-29       Impact factor: 13.281

Review 4.  Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair.

Authors:  Polina Goichberg
Journal:  Stem Cell Rev Rep       Date:  2016-08       Impact factor: 5.739

5.  Stimulatory Effects of Mesenchymal Stem Cells on cKit+ Cardiac Stem Cells Are Mediated by SDF1/CXCR4 and SCF/cKit Signaling Pathways.

Authors:  Konstantinos E Hatzistergos; Dieter Saur; Barbara Seidler; Wayne Balkan; Matthew Breton; Krystalenia Valasaki; Lauro M Takeuchi; Ana Marie Landin; Aisha Khan; Joshua M Hare
Journal:  Circ Res       Date:  2016-08-01       Impact factor: 17.367

Review 6.  Adhesion-Based Self-Organization in Tissue Patterning.

Authors:  Tony Y-C Tsai; Rikki M Garner; Sean G Megason
Journal:  Annu Rev Cell Dev Biol       Date:  2022-05-13       Impact factor: 11.902

7.  Truncated EphA2 likely potentiates cell adhesion via integrins as well as infiltration and/or lodgment of a monocyte/macrophage cell line in the red pulp and marginal zone of the mouse spleen, where ephrin-A1 is prominently expressed in the vasculature.

Authors:  Naoko Konda; Noritaka Saeki; Shingo Nishino; Kazushige Ogawa
Journal:  Histochem Cell Biol       Date:  2016-09-24       Impact factor: 4.304

Review 8.  Harnessing the Power of Eph/ephrin Biosemiotics for Theranostic Applications.

Authors:  Robert M Hughes; Jitka A I Virag
Journal:  Pharmaceuticals (Basel)       Date:  2020-06-01

Review 9.  Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment.

Authors:  Agnieszka Arthur; Stan Gronthos
Journal:  Front Cell Dev Biol       Date:  2021-02-09
  9 in total

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