Athina C Tsili1, Loukas G Astrakas2, Alexandra Ntorkou3, Dimitrios Giannakis4, Sotirios Stavrou5, Vasilios Maliakas6, Nikolaos Sofikitis4, Maria I Argyropoulou3. 1. Department of Clinical Radiology, Medical School, University of Ioannina, 45110, Ioannina, Greece. a_tsili@yahoo.gr. 2. Department of Medical Physics, Medical School, University of Ioannina, 45110, Ioannina, Greece. 3. Department of Clinical Radiology, Medical School, University of Ioannina, 45110, Ioannina, Greece. 4. Department of Urology, Medical School, University of Ioannina, 45110, Ioannina, Greece. 5. Department of Urology, University Hospital of Ioannina, Leoforos S. Niarchou, 45500, Ioannina, Greece. 6. Department of Clinical Radiology, University Hospital of Ioannina, Leoforos S. Niarchou, 45500, Ioannina, Greece.
Abstract
OBJECTIVES: The aim was to determine the proton MR (1H-MR) spectra of normal adult testes and variations with age. METHODS: Forty-one MR spectra of normal testes, including 16 testes from men aged 20-39 years (group I) and 25 testes from men aged 40-69 years (group II), were analyzed. A single-voxel point-resolved spectroscopy sequence (PRESS), with TR/TE: 2000/25 ms was used. The volume of interest was placed to include the majority of normal testicular parenchyma. Association between normalized metabolite concentrations, defined as ratios of the calculated metabolite concentrations relative to creatine concentration, and age was assessed. RESULTS: Quantified metabolites of the spectra were choline (Cho), creatine (Cr), myo-inositol (mI), scyllo-inositol, taurine, lactate, GLx compound, glucose, lipids, and macromolecules resonating at 0.9 ppm (LM09), around 20 ppm (LM20), and at 13 ppm (LM13). Most prominent peaks were Cho, Cr, mI, and lipids. A weak negative correlation between mI and age (P = 0.015) was observed. Higher normalized concentrations of Cho (P = 0.03), mI (P = 0.08), and LM13 (P = 0.05) were found in group I than in group II. CONCLUSIONS: 1H-MR spectra of a normal adult testis showed several metabolite peaks. A decrease of levels of Cho, mI, and LM13 was observed with advancing age. KEY POINTS: • Single-voxel PRESS MRS of a normal testis is feasible. • 1H-MR spectra of a normal testis showed several metabolite peaks. • Most prominent peaks were Cho, Cr, mI, and lipids. • A decrease of Cho, mI, and LM13 was seen with advancing age.
OBJECTIVES: The aim was to determine the proton MR (1H-MR) spectra of normal adult testes and variations with age. METHODS: Forty-one MR spectra of normal testes, including 16 testes from men aged 20-39 years (group I) and 25 testes from men aged 40-69 years (group II), were analyzed. A single-voxel point-resolved spectroscopy sequence (PRESS), with TR/TE: 2000/25 ms was used. The volume of interest was placed to include the majority of normal testicular parenchyma. Association between normalized metabolite concentrations, defined as ratios of the calculated metabolite concentrations relative to creatine concentration, and age was assessed. RESULTS: Quantified metabolites of the spectra were choline (Cho), creatine (Cr), myo-inositol (mI), scyllo-inositol, taurine, lactate, GLx compound, glucose, lipids, and macromolecules resonating at 0.9 ppm (LM09), around 20 ppm (LM20), and at 13 ppm (LM13). Most prominent peaks were Cho, Cr, mI, and lipids. A weak negative correlation between mI and age (P = 0.015) was observed. Higher normalized concentrations of Cho (P = 0.03), mI (P = 0.08), and LM13 (P = 0.05) were found in group I than in group II. CONCLUSIONS:1H-MR spectra of a normal adult testis showed several metabolite peaks. A decrease of levels of Cho, mI, and LM13 was observed with advancing age. KEY POINTS: • Single-voxel PRESS MRS of a normal testis is feasible. • 1H-MR spectra of a normal testis showed several metabolite peaks. • Most prominent peaks were Cho, Cr, mI, and lipids. • A decrease of Cho, mI, and LM13 was seen with advancing age.
Entities:
Keywords:
Choline; Imaging; Magnetic resonance imaging; Magnetic resonance spectroscopy; Testis
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