| Literature DB >> 26474298 |
P J Held1, F McCormick2, A Ojo3, J P Roberts4.
Abstract
From 5000 to 10 000 kidney patients die prematurely in the United States each year, and about 100 000 more suffer the debilitating effects of dialysis, because of a shortage of transplant kidneys. To reduce this shortage, many advocate having the government compensate kidney donors. This paper presents a comprehensive cost-benefit analysis of such a change. It considers not only the substantial savings to society because kidney recipients would no longer need expensive dialysis treatments--$1.45 million per kidney recipient--but also estimates the monetary value of the longer and healthier lives that kidney recipients enjoy--about $1.3 million per recipient. These numbers dwarf the proposed $45 000-per-kidney compensation that might be needed to end the kidney shortage and eliminate the kidney transplant waiting list. From the viewpoint of society, the net benefit from saving thousands of lives each year and reducing the suffering of 100 000 more receiving dialysis would be about $46 billion per year, with the benefits exceeding the costs by a factor of 3. In addition, it would save taxpayers about $12 billion each year.Entities:
Keywords: clinical research/practice; dialysis; donors and donation: living; health services and outcomes research; kidney transplantation/nephrology; kidney transplantation: living donor; law/legislation; organ allocation; organ transplantation in general; quality of life (QOL)
Mesh:
Year: 2015 PMID: 26474298 PMCID: PMC5057320 DOI: 10.1111/ajt.13490
Source DB: PubMed Journal: Am J Transplant ISSN: 1600-6135 Impact factor: 8.086
Key estimates and calculations
|
|
Increase in life years from receiving a transplant compared with remaining on dialysis on waiting list
| No donor compensation (current situation) (2015) | If donors are compensated (steady state after first 5 years) (2020) | ||
|---|---|---|---|
| Expected remaining lifetime (half‐life in years) | If remain on dialysis on waiting list | 12.3 | 15.0 |
| If receive a transplant | 19.3 | 24.9 | |
| Increase in life years from receiving a transplant (vs remaining on dialysis on waiting list) | Increase in life years (unadjusted) | 7.0 | 9.9* |
| Increase in discounted QALYs | 4.7 | 6.7 | |
| Half‐life of transplant kidney graft | 12.6* | 15.7 | |
In the current situation, when the graft fails in 12.6 years, 86% of the patients go back on dialysis. In the steady state case, when the first graft fails, most patients will be readily able to obtain a second transplant kidney.
Based on only 14% receiving a second transplant. In the steady state case, the percentage may approach 100%; hence the number (9.9) may approach 12 years.
Sources: USRDS 2013 annual data report 7; SRTR (2012) 8; Laupacis et al (1996) 14; Russell et al (1992) 15; Hirth et al (2000) 11.
Present value of benefits and costs over a kidney recipient's lifetime (per kidney recipient)
| No donor compensation (current situation) | If donors are compensated (steady state after first 5 years) | |
|---|---|---|
| Benefits | ||
| Welfare gain for kidney recipient (over a lifetime) | $937 000 | $1 335 000 |
| Savings from stopping dialysis (over a lifetime) | $735 000 | $1 454 000 |
| Costs | ||
| Cost of transplant (everything at time of transplant except compensation to donors) | $145 000 | $236 000 |
| Compensation to donors | $0 | $73 000 |
| Medical costs after transplant (including cost of kidney graft failure) | $395 000 | $607 000 |
| Net welfare gain for society per kidney recipient | $1 132 000 | $1 873 000 |
| Addendum | ||
| Taxpayer savings per kidney recipient | $146 000 | $403 000 |
Sources: USRDS 2013 annual data report 7; SRTR (2012) 8; Laupacis et al (1996) 14; Russell et al (1992) 15; Hirth et al (2000) 11.
Present value of benefits and costs for all kidney recipients in a given year (per year)
| No donor compensation (current situation) | If donors are compensated (steady state after first 5 years) | |
|---|---|---|
| 17 500 kidney recipients per year | 35 000 kidney recipients per year | |
| Benefits | ||
| Welfare gain for all kidney recipients in a given year | $16.4 billion/y | $46.7 billion/y |
| Savings from stopping dialysis for all kidney recipients in a given year | $12.9 billion/y | $50.9 billion/y |
| Costs | ||
| Costs of transplants for all kidney recipients in a given year (everything at time of transplant except compensation to donors) | $2.5 billion/y | $8.3 billion/y |
| Compensation to donors for all kidney recipients in a given year | 0 | $2.6 billion/y |
| Medical costs after transplant for all kidney recipients in a given year (including cost of kidney graft failure) | $6.9 billion/y | $21.2 billion/y |
| Net welfare gain for society from all transplant recipients in a given year | $19.8 billion/y | $65.6 billion/y |
| Addendum | ||
| Taxpayer savings from all transplant recipients in a given year | $2.6 billion/y | $14.1 billion/y |
| Benefit‐cost ratio for society | 3.0 | |
| Benefit‐cost ratio for taxpayers | 1.7 | |
Sources: USRDS 2013 annual data report 7; SRTR (2012) 8; Laupacis et al (1996) 14; Russell et al (1992) 15; Hirth et al (2000) 11.
Figure 1Two treatment paths for ESRD: dialysis or transplant (with donor compensation, steady state, 2020). ESRD, end‐stage renal disease.
| No. | Name | Pg. No. |
|---|---|---|
| 1 | Important Footnotes for Main Text | 2–11 |
| 2 | Detailed Calculations of Costs and Benefits | 12–18 |
| 3 | Compensating Kidney Donors Would Be a Boon for the Poor | 19–21 |
| 4 | Comparison of Matas and Schnitzler with Held and McCormick et al. (this paper) | 22–23 |
| 5 | Estimates of Transplant and Dialysis Costs | 24–32 |
| 6 | Some Arguments Against Compensating Kidney Donors | 33–35 |
| 7 | Conservative Assumptions | 36–38 |
| 8 | Sensitivity Analyses | 39–44 |
| 1. Compensation | ||
| 2. Value of a QALY | ||
| 3. Quality of Life | ||
| 9 | Living vs. Deceased Donors Under a Donor Compensation Program | 45–46 |
| 10 | Cost of a Quality Adjusted Life Year: Dialysis vs. Transplantation | 47–48 |
| 11 | Capacity of U.S. Kidney Transplant Centers | 49 |
| 12 | Estimating Half‐Lives of Dialysis Patients, Transplant Patients, and Kidney Grafts | 50–66 |