Literature DB >> 26473429

Identification of the Polyketide Biosynthetic Machinery for the Indolizidine Alkaloid Cyclizidine.

Wei Huang1, Seong Jong Kim1, Joyce Liu1, Wenjun Zhang1.   

Abstract

The cyclizidine biosynthetic gene cluster was identified from Streptomyces NCIB 11649, which revealed the polyketide biosynthetic machinery for cyclizidine alkaloid biosynthesis. Both in vivo mutagenesis study and in vitro biochemical analysis provided insight into the timing and mechanism of the biosynthetic enzymes that produce cyclizidine-type indolizidine alkaloids.

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Year:  2015        PMID： 26473429      PMCID： PMC4646845          DOI： 10.1021/acs.orglett.5b02707

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  25 in total

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6.  Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis.

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7.  New Insights into the Biosynthesis Pathway of Polyketide Alkaloid Argimycins P in Streptomyces argillaceus.

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