OBJECTIVE: To test the reliability of the consensus-based ultrasound (US) definitions of elementary gout lesions in patients. METHODS: Eight patients with microscopically proven gout were evaluated by 16 sonographers for signs of double contour (DC), aggregates, erosions, and tophi in the first metatarsophalangeal joint and the knee bilaterally. The patients were examined twice using B-mode US to test agreement and inter- and intraobserver reliability of the elementary components. RESULTS: The prevalence of the lesions were DC 52.8%, tophus 61.1%, aggregates 29.8%, and erosions 32.4%. The intraobserver reliability was good for all lesions except DC, where it was moderate. The best reliability per lesion was seen for tophus (κ 0.73, 95% CI 0.61-0.85) and lowest for DC (κ 0.53, 95% CI 0.38-0.67). The interobserver reliability was good for tophus and erosions, but fair to moderate for aggregates and DC, respectively. The best reliability was seen for erosions (κ 0.74, 95% CI 0.65-0.81) and lowest for aggregates (κ 0.21, 95% CI 0.04-0.37). CONCLUSION: This is the first step to test consensus-based US definitions on elementary lesions in patients with gout. High intraobserver reliability was found when applying the definition in patients on all elementary lesions while interobserver reliability was moderate to low. Further studies are needed to improve the interobserver reliability, particularly for DC and aggregates.
OBJECTIVE: To test the reliability of the consensus-based ultrasound (US) definitions of elementary gout lesions in patients. METHODS: Eight patients with microscopically proven gout were evaluated by 16 sonographers for signs of double contour (DC), aggregates, erosions, and tophi in the first metatarsophalangeal joint and the knee bilaterally. The patients were examined twice using B-mode US to test agreement and inter- and intraobserver reliability of the elementary components. RESULTS: The prevalence of the lesions were DC 52.8%, tophus 61.1%, aggregates 29.8%, and erosions 32.4%. The intraobserver reliability was good for all lesions except DC, where it was moderate. The best reliability per lesion was seen for tophus (κ 0.73, 95% CI 0.61-0.85) and lowest for DC (κ 0.53, 95% CI 0.38-0.67). The interobserver reliability was good for tophus and erosions, but fair to moderate for aggregates and DC, respectively. The best reliability was seen for erosions (κ 0.74, 95% CI 0.65-0.81) and lowest for aggregates (κ 0.21, 95% CI 0.04-0.37). CONCLUSION: This is the first step to test consensus-based US definitions on elementary lesions in patients with gout. High intraobserver reliability was found when applying the definition in patients on all elementary lesions while interobserver reliability was moderate to low. Further studies are needed to improve the interobserver reliability, particularly for DC and aggregates.
Authors: Tomas Cazenave; Victoria Martire; Anthony M Reginato; Marwin Gutierrez; Christian Alfredo Waimann; Carlos Pineda; Javier Eduardo Rosa; Santiago Ruta; Oscar Sedano-Santiago; Ana Maria Bertoli; Marcelo Audisio; Cristina Hernandez-Diaz; Lucio Ventura-Rios; Maritza Quintero; Eugenio De Miguel; Ana Laura Alvarez-Del-Castillo-Araujo; Andy Abril; Eliana Natalí Ayala-Ledesma; Edith Alarcon-Isidro; Maria Lida Santiago; Mariana Alejandra Pera; Cecilia Urquiola; Gustavo Rodriguez Gil; Lina Maria Saldarriaga Rivera; Cesar Cefferino; Mariana Benegas; Mario Enrique Diaz Cortes; Maximiliano Bravo; Diana Peiteado; Natalia Anahi Estrella; Roser Areny Micas; Jorge Saavedra Muñoz; Rodolfo Del Carmen Arape Toyo; Maria Soledad Gálvez Elkin; Walter Javier Spindler; Clarisa Sandobal; Josefina Marin; Manuella Lima Gomes Ochtrop; Ricardo Pavao Ayala; Erika Roxana Catay; Guillermo Enrique Py; Gabriel Hector Aguilar; Yvonne Yona Rengel Colina; Carla Antonela Airoldi; Claudia Selene Mora-Trujillo; Maria Paula Kohan; Lorena Evelin Urioste Eguez; Concepción Castillo-Gallego; Jose Francisco Diaz-Coto; Patricio Tate; Carla Magali Saucedo; Oscar Vega-Hinojosa; Cristian Jonatan Troitiño; Maria Florencia Marengo; Priscila Maria Marcaida; Irene Monjo Henry; Roberto Muñoz-Louis; Carla Solano; Felix Reinaldo Fernandez Castillo; Cesar Enrique Graf; Mara Guinsburg; Maria Julia Santa Cruz; David Alejandro Navarta Ortiz; Magaly Alva Linares; Marcos Gabriel Rosemffet Journal: Rheumatol Int Date: 2018-12-11 Impact factor: 2.631
Authors: Alexis Ogdie; William J Taylor; Tuhina Neogi; Jaap Fransen; Tim L Jansen; H Ralph Schumacher; Worawit Louthrenoo; Janitzia Vazquez-Mellado; Maxim Eliseev; Geraldine McCarthy; Lisa K Stamp; Fernando Perez-Ruiz; Francisca Sivera; Hang-Korng Ea; Martijn Gerritsen; Giovanni Cagnotto; Lorenzo Cavagna; Chingtsai Lin; Yin-Yi Chou; Anne-Kathrin Tausche; Manuella Lima Gomes Ochtrop; Matthijs Janssen; Jiunn-Horng Chen; Ole Slot; Juris Lazovskis; Douglas White; Marco A Cimmino; Till Uhlig; Nicola Dalbeth Journal: Arthritis Rheumatol Date: 2017-02 Impact factor: 10.995
Authors: Lucio Ventura-Ríos; Guadalupe Sánchez-Bringas; Carlos Pineda; Cristina Hernández-Díaz; Anthony Reginato; Magaly Alva; Marcelo Audisio; Ana Bertoli; Tomas Cazenave; Marwin Gutiérrez; Claudia Mora; Guillermo Py; Oscar Sedano; Carla Solano; Eugenio de Miguel Journal: Clin Rheumatol Date: 2016-05-28 Impact factor: 2.980
Authors: Baptiste Dubief; Julien Avril; Tristan Pascart; Marie Schmitt; Romaric Loffroy; Jean-Francis Maillefert; Paul Ornetti; André Ramon Journal: Quant Imaging Med Surg Date: 2022-01
Authors: Y Y Yan; Y N Bin Dous; H A Ouellette; P L Munk; N Murray; P I Mallinson; M A Sheikh Journal: Skeletal Radiol Date: 2021-06-21 Impact factor: 2.199
Authors: Edoardo Cipolletta; Jacopo Di Battista; Marco Di Carlo; Andrea Di Matteo; Fausto Salaffi; Walter Grassi; Emilio Filippucci Journal: Arthritis Res Ther Date: 2021-07-09 Impact factor: 5.156