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Literature DB >> 2647212

The elucidation of protein function by sequence motif analysis.

Abstract

Protein sequence motifs are acquiring increasing prominence in the area of sequence analysis. This review describes the current methods of their construction and their use in the determination of protein function, and offers guidelines on interpreting data obtained. An appendix is attached which refers to 200 motifs of various kinds.

Mesh：

Substances：
Proteins

Year: 1989 PMID： 2647212 DOI： 10.1093/bioinformatics/5.1.1

Source DB: PubMed Journal: Comput Appl Biosci ISSN： 0266-7061

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Cited

10 in total

1. Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

Authors: J R Carter; M A Franden; R Aebersold; C S McHenry
Journal: J Bacteriol Date: 1992-11 Impact factor: 3.490

2. Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria.

Authors: T V Ilyina; E V Koonin
Journal: Nucleic Acids Res Date: 1992-07-11 Impact factor: 16.971

Review 3. Viral proteins containing the purine NTP-binding sequence pattern.

Authors: A E Gorbalenya; E V Koonin
Journal: Nucleic Acids Res Date: 1989-11-11 Impact factor: 16.971

4. The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

Authors: D Kretzschmar; G Hasan; S Sharma; M Heisenberg; S Benzer
Journal: J Neurosci Date: 1997-10-01 Impact factor: 6.167

5. Identification, isolation, and characterization of the structural gene encoding the delta' subunit of Escherichia coli DNA polymerase III holoenzyme.

Authors: J R Carter; M A Franden; R Aebersold; C S McHenry
Journal: J Bacteriol Date: 1993-06 Impact factor: 3.490

The elucidation of protein function by sequence motif analysis.

1. Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme.

2. Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria.

Review 3. Viral proteins containing the purine NTP-binding sequence pattern.

4. The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila.

5. Identification, isolation, and characterization of the structural gene encoding the delta' subunit of Escherichia coli DNA polymerase III holoenzyme.

6. The PROSITE dictionary of sites and patterns in proteins, its current status.

7. Novel protein families in archaean genomes.

8. PROSITE: recent developments.

9. Detection of conserved segments in proteins: iterative scanning of sequence databases with alignment blocks.

10. CoSMoS: Conserved Sequence Motif Search in the proteome.