PURPOSE: The aim of this study was to determine the bone mineral density (BMD) and the factors leading to reduction in BMD in children diagnosed with meningomyelocele. METHODS: A total of 31 patients with meningomyelocele (mean (SD) age, 8.5 (3.9) years; 51.6%were females) and 22 healthy children were included. BMD of femoral neck and spinal L1– L4 levels and markers for bone metabolism were recorded. RESULTS: BMD of femoral neck (p=0.001) and spinal L1–L4 (p = 0.01), serum calcium (p = 0.031), and urinary deoxypyridinoline (p=0.015) levels were significantly lower in patients than in controls. Mobilization was significantly reduced in lumbar (p=0.001) and thoracic (p=0.002) level meningomyelocele compared to controls, while a significant positive correlation was noted between BMD of spinal L1–L4 and mobility (r=0.58, p=0.015). CONCLUSIONS: Our findings suggest a decrease in BMD in meningomyelocele patients being associated with osteoporosis rather than nutritional and hormonal factors and the negative impact of higher levels of lesion on the mobility.
PURPOSE: The aim of this study was to determine the bone mineral density (BMD) and the factors leading to reduction in BMD in children diagnosed with meningomyelocele. METHODS: A total of 31 patients with meningomyelocele (mean (SD) age, 8.5 (3.9) years; 51.6%were females) and 22 healthy children were included. BMD of femoral neck and spinal L1– L4 levels and markers for bone metabolism were recorded. RESULTS: BMD of femoral neck (p=0.001) and spinal L1–L4 (p = 0.01), serum calcium (p = 0.031), and urinary deoxypyridinoline (p=0.015) levels were significantly lower in patients than in controls. Mobilization was significantly reduced in lumbar (p=0.001) and thoracic (p=0.002) level meningomyelocele compared to controls, while a significant positive correlation was noted between BMD of spinal L1–L4 and mobility (r=0.58, p=0.015). CONCLUSIONS: Our findings suggest a decrease in BMD in meningomyelocele patients being associated with osteoporosis rather than nutritional and hormonal factors and the negative impact of higher levels of lesion on the mobility.
Authors: V Martinelli; C Dell'Atti; E Ausili; E Federici; N Magarelli; A Leone; L Massimi; C Di Rocco; L Bonomo; C Rendeli Journal: Childs Nerv Syst Date: 2015-05-01 Impact factor: 1.475
Authors: E Michael Lewiecki; Catherine M Gordon; Sanford Baim; Mary B Leonard; Nicholas J Bishop; Maria-Luisa Bianchi; Heidi J Kalkwarf; Craig B Langman; Horatio Plotkin; Frank Rauch; Babette S Zemel; Neil Binkley; John P Bilezikian; David L Kendler; Didier B Hans; Stuart Silverman Journal: Bone Date: 2008-08-15 Impact factor: 4.398
Authors: Michael Akbar; Bjoern Bresch; Patric Raiss; Carl Hans Fürstenberg; Thomas Bruckner; Thorsten Seyler; Claus Carstens; Rainer Abel Journal: J Orthop Traumatol Date: 2010-08-19
Authors: B Okurowska-Zawada; J Konstantynowicz; W Kułak; M Kaczmarski; J Piotrowska-Jastrzebska; D Sienkiewicz; G Paszko-Patej Journal: Adv Med Sci Date: 2009 Impact factor: 3.287