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Literature DB >> 26468743

The Quest for a Universal Flu Vaccine: Headless HA 2.0.

Abstract

Two recent publications report the design of immunogens based on the conserved stalk domain of the influenza virus hemagglutinin. These new "headless" hemagglutinin constructs recapitulate the epitopes recognized by broadly neutralizing antibodies and induce broadly protective/heterosubtypic immunity in animal models, bringing us a step closer to "universal" influenza virus vaccines.

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Year: 2015 PMID： 26468743 DOI： 10.1016/j.chom.2015.10.003

Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023

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Cited

28 in total

1. Hemagglutinin head-specific responses dominate over stem-specific responses following prime boost with mismatched vaccines.

Authors: Sinthujan Jegaskanda; Sarah F Andrews; Adam K Wheatley; Jonathan W Yewdell; Adrian B McDermott; Kanta Subbarao
Journal: JCI Insight Date: 2019-11-14

10. Pan-Influenza A Protection by Prime-Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model.

Authors: Yo Han Jang; Joo Young Kim; Young Ho Byun; Ahyun Son; Jeong-Yoon Lee; Yoon Jae Lee; Jun Chang; Baik Lin Seong
Journal: Front Immunol Date: 2018-02-01 Impact factor: 7.561

The Quest for a Universal Flu Vaccine: Headless HA 2.0.

1. Hemagglutinin head-specific responses dominate over stem-specific responses following prime boost with mismatched vaccines.

Review 2. From Original Antigenic Sin to the Universal Influenza Virus Vaccine.

3. Mosaic H5 Hemagglutinin Provides Broad Humoral and Cellular Immune Responses against Influenza Viruses.

Review 4. Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?

Review 5. The human antibody response to influenza A virus infection and vaccination.

Review 6. Universal influenza virus vaccines and therapeutic antibodies.

Review 7. Novel universal influenza virus vaccine approaches.

Review 8. Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines.

9. Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses.

10. Pan-Influenza A Protection by Prime-Boost Vaccination with Cold-Adapted Live-Attenuated Influenza Vaccine in a Mouse Model.