Literature DB >> 26468520

Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest.

Yizhong Ren1, Chufang Li2, Liqiang Feng3, Weiqi Pan4, Liang Li4, Qian Wang3, Jiashun Li4, Na Li4, Ling Han4, Xuehua Zheng4, Xuefeng Niu4, Caijun Sun3, Ling Chen5.   

Abstract

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosomes with lysosomes, which might be a key mechanism for arresting autophagy.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26468520      PMCID： PMC4702553          DOI： 10.1128/JVI.00576-15

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

Review 1.  TOR, a central controller of cell growth.

Authors:  T Schmelzle; M N Hall
Journal:  Cell       Date:  2000-10-13       Impact factor: 41.582

2.  Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.

Authors:  Amina Tassa; Marie Paule Roux; Didier Attaix; Daniel M Bechet
Journal:  Biochem J       Date:  2003-12-15       Impact factor: 3.857

Review 3.  The M2 proton channels of influenza A and B viruses.

Authors:  Lawrence H Pinto; Robert A Lamb
Journal:  J Biol Chem       Date:  2005-12-30       Impact factor: 5.157

4.  Selective perturbation of early endosome and/or trans-Golgi network pH but not lysosome pH by dose-dependent expression of influenza M2 protein.

Authors:  J R Henkel; J L Popovich; G A Gibson; S C Watkins; O A Weisz
Journal:  J Biol Chem       Date:  1999-04-02       Impact factor: 5.157

5.  Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue.

Authors:  C Wang; R A Lamb; L H Pinto
Journal:  Biophys J       Date:  1995-10       Impact factor: 4.033

6.  Accumulation of autophagosomes after inhibition of hepatocytic protein degradation by vinblastine, leupeptin or a lysosomotropic amine.

Authors:  A L Kovács; A Reith; P O Seglen
Journal:  Exp Cell Res       Date:  1982-01       Impact factor: 3.905

7.  Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.

Authors:  K S Li; Y Guan; J Wang; G J D Smith; K M Xu; L Duan; A P Rahardjo; P Puthavathana; C Buranathai; T D Nguyen; A T S Estoepangestie; A Chaisingh; P Auewarakul; H T Long; N T H Hanh; R J Webby; L L M Poon; H Chen; K F Shortridge; K Y Yuen; R G Webster; J S M Peiris
Journal:  Nature       Date:  2004-07-08       Impact factor: 49.962

8.  p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Authors:  Geir Bjørkøy; Trond Lamark; Andreas Brech; Heidi Outzen; Maria Perander; Aud Overvatn; Harald Stenmark; Terje Johansen
Journal:  J Cell Biol       Date:  2005-11-14       Impact factor: 10.539

9.  Subversion of cellular autophagosomal machinery by RNA viruses.

Authors:  William T Jackson; Thomas H Giddings; Matthew P Taylor; Sara Mulinyawe; Marlene Rabinovitch; Ron R Kopito; Karla Kirkegaard
Journal:  PLoS Biol       Date:  2005-04-26       Impact factor: 8.029

10.  A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability.

Authors:  Rupert Beale; Helen Wise; Amanda Stuart; Benjamin J Ravenhill; Paul Digard; Felix Randow
Journal:  Cell Host Microbe       Date:  2014-02-12       Impact factor: 21.023
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  23 in total

1.  Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production.

Authors:  Ruifang Wang; Yinxing Zhu; Xian Lin; Chenwei Ren; Jiachang Zhao; Fangfang Wang; Xiaochen Gao; Rong Xiao; Lianzhong Zhao; Huanchun Chen; Meilin Jin; Wenjun Ma; Hongbo Zhou
Journal:  Autophagy       Date:  2019-02-20       Impact factor: 16.016

2.  Influenza A virus protein PB1-F2 impairs innate immunity by inducing mitophagy.

Authors:  Ruifang Wang; Yinxing Zhu; Chenwei Ren; Shuaike Yang; Shan Tian; Huanchun Chen; Meilin Jin; Hongbo Zhou
Journal:  Autophagy       Date:  2020-02-11       Impact factor: 16.016

3.  Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication.

Authors:  Jingting Zhang; Tao Ruan; Tianyu Sheng; Jiongjiong Wang; Jing Sun; Jin Wang; Richard A Prinz; Daxin Peng; Xiufan Liu; Xiulong Xu
Journal:  Virology       Date:  2018-10-10       Impact factor: 3.616

4.  Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy.

Authors:  Laura Martin-Sancho; Shashank Tripathi; Ariel Rodriguez-Frandsen; Lars Pache; Maite Sanchez-Aparicio; Michael J McGregor; Kelsey M Haas; Danielle L Swaney; Thong T Nguyen; João I Mamede; Christopher Churas; Dexter Pratt; Sara B Rosenthal; Laura Riva; Courtney Nguyen; Nish Beltran-Raygoza; Stephen Soonthornvacharin; Guojun Wang; David Jimenez-Morales; Paul D De Jesus; Hong M Moulton; David A Stein; Max W Chang; Chris Benner; Trey Ideker; Randy A Albrecht; Judd F Hultquist; Nevan J Krogan; Adolfo García-Sastre; Sumit K Chanda
Journal:  Nat Microbiol       Date:  2021-09-23       Impact factor: 30.964

5.  Sarco/Endoplasmic Reticulum Ca2+ Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells.

Authors:  Jiaojiao Peng; Yeqian Ran; Haojun Xie; Ling Deng; Chufang Li; Chen Ling
Journal:  J Virol       Date:  2021-03-10       Impact factor: 5.103

6.  Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein Is Crucial for Production of Infectious Virus Particles.

Authors:  Wen-Chi Su; Wen-Ya Yu; Shih-Han Huang; Michael M C Lai
Journal:  J Virol       Date:  2018-01-30       Impact factor: 5.103

7.  The M2 protein of live, attenuated influenza vaccine encodes a mutation that reduces replication in human nasal epithelial cells.

Authors:  Nicholas Wohlgemuth; Yang Ye; Katherine J Fenstermacher; Hsuan Liu; Andrew P Lane; Andrew Pekosz
Journal:  Vaccine       Date:  2017-10-25       Impact factor: 3.641

8.  Host Cellular Protein TRAPPC6AΔ Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking.

Authors:  Pengyang Zhu; Libin Liang; Xinyuan Shao; Weiyu Luo; Shuitao Jiang; Qingqing Zhao; Nan Sun; Yuhui Zhao; Junping Li; Jinguang Wang; Yuan Zhou; Jie Zhang; Guangwen Wang; Li Jiang; Hualan Chen; Chengjun Li
Journal:  J Virol       Date:  2016-12-16       Impact factor: 5.103

Review 9.  The Autophagic Machinery in Viral Exocytosis.

Authors:  Christian Münz
Journal:  Front Microbiol       Date:  2017-02-21       Impact factor: 5.640

10.  Cathepsin B plays a key role in optimal production of the influenza A virus.

Authors:  Macon D Coleman; Soon-Duck Ha; S M Mansour Haeryfar; Stephen Dominic Barr; Sung Ouk Kim
Journal:  J Virol Antivir Res       Date:  2018-05-11
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