Literature DB >> 2646794

Chromosome error propagation and cancer.

R Holliday.   

Abstract

A general characteristic of tumour cells is their unstable karyotype. It is suggested here that maintenance of the normal diploid cell depends on the presence of two copies of specific genes; a change in gene dosage of one or more of these genes, by chromosome nondisjunction or rearrangement, may trigger a general loss of accuracy in chromosome segregation at mitosis.

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Year:  1989        PMID： 2646794     DOI： 10.1016/0168-9525(89)90020-6

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  17 in total

Review 1.  Auto-catalysed progression of aneuploidy explains the Hayflick limit of cultured cells, carcinogen-induced tumours in mice, and the age distribution of human cancer.

Authors:  D Rasnick
Journal:  Biochem J       Date:  2000-06-15       Impact factor: 3.857

2.  Karyotypic change from heteroploidy to near diploidy associated with development of cisplatin resistance in a rat ovarian tumour cell line.

Authors:  G Chen; K J Hutter; J Bullerdiek; W J Zeller
Journal:  J Cancer Res Clin Oncol       Date:  1991       Impact factor: 4.553

3.  A quantitative assay to measure chromosome stability in Schizosaccharomyces pombe.

Authors:  Z Bodi; A Gysler-Junker; J Kohli
Journal:  Mol Gen Genet       Date:  1991-09

4.  Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi.

Authors:  A F Cowman; A M Lew
Journal:  Mol Cell Biol       Date:  1989-11       Impact factor: 4.272

5.  Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11.

Authors:  H J Scrable; D K Johnson; E M Rinchik; W K Cavenee
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

6.  Chromosomal drive and the evolution of meiotic nondisjunction and trisomy in humans.

Authors:  T Day; P D Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

7.  Retrovirus-mediated transfer of an adenovirus gene encoding an integral membrane protein is sufficient to down regulate the receptor for epidermal growth factor.

Authors:  B L Hoffman; A Ullrich; W S Wold; C R Carlin
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

8.  How aneuploidy affects metabolic control and causes cancer.

Authors:  D Rasnick; P H Duesberg
Journal:  Biochem J       Date:  1999-06-15       Impact factor: 3.857

9.  Adjuvant Chemotherapy for Stage II Colon Cancer: The Role of Molecular Markers in Choosing Therapy.

Authors:  Patrick Chun; Zev A Wainberg
Journal:  Gastrointest Cancer Res       Date:  2009-09

10.  DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice.

Authors:  E P Sandgren; R D Palmiter; J L Heckel; R L Brinster; J L Degen
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205
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