E dos Santos Dias1, T N do Prado2, A L da Silva Guimarães1, M C Ramos3, C M M Sales2, E de Fátima Almeida Lima3, C C Sant'Anna4, M Sanchez5, E L Maciel6. 1. Laboratory of Epidemiology, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil. 2. Laboratory of Epidemiology, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; Post-Graduate Programme in Infectious Diseases, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil. 3. School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil. 4. Faculty of Medicine<sup>, </sup> Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. 5. Department of Public Health, University of Brasilia, Brasilia DF, Brazil. 6. Laboratory of Epidemiology, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; School of Nursing, Federal University of Espírito Santo, Vitória, Espírito Santo, Rio de Janeiro, Brazil; Post-Graduate Programme in Infectious Diseases, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil; Post-Graduate Program in Public Health, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil.
Abstract
SETTING: Human immunodeficiency virus (HIV) infection may impact tuberculosis (TB) diagnosis, clinical presentation and treatment outcomes in children as the signs and symptoms of both diseases overlap. OBJECTIVE: To compare the sociodemographic and clinical profiles of childhood TB according to HIV status in Brazil. METHODS: This was a cross-sectional study of data on subjects aged <15 years retrieved from the Brazilian National Electronic Disease Registry (Sistema de Informação de Agravos de Notificação) database on TB to compare TB-HIV coinfected patients and patients with TB only registered between 2007 and 2011. A hierarchical logistic regression model was applied. RESULTS: Of 6091 cases analysed, 780 (12%) were TB-HIV patients, while 5311 (87%) presented with TB only. TB-HIV patients were more likely to be institutionalised (OR 2.22, 95%CI 1.43-3.46), to present with relapsed TB (OR 5.03, 95%CI 2.02-12.5) and be readmitted after treatment default (OR 16.7, 95%CI 4.34-64.46). They were also more likely to have unfavourable outcomes, including default (OR 2.85, 95%CI 1.81-4.49), death due to TB (OR 2.76, 95%CI 1.27-6.03) and death from other causes (OR 5.59, 95%CI 2.63-11.8). CONCLUSION: Our study highlights the challenges of using national registers for research into childhood TB.
SETTING:Human immunodeficiency virus (HIV) infection may impact tuberculosis (TB) diagnosis, clinical presentation and treatment outcomes in children as the signs and symptoms of both diseases overlap. OBJECTIVE: To compare the sociodemographic and clinical profiles of childhood TB according to HIV status in Brazil. METHODS: This was a cross-sectional study of data on subjects aged <15 years retrieved from the Brazilian National Electronic Disease Registry (Sistema de Informação de Agravos de Notificação) database on TB to compare TB-HIV coinfectedpatients and patients with TB only registered between 2007 and 2011. A hierarchical logistic regression model was applied. RESULTS: Of 6091 cases analysed, 780 (12%) were TB-HIVpatients, while 5311 (87%) presented with TB only. TB-HIVpatients were more likely to be institutionalised (OR 2.22, 95%CI 1.43-3.46), to present with relapsed TB (OR 5.03, 95%CI 2.02-12.5) and be readmitted after treatment default (OR 16.7, 95%CI 4.34-64.46). They were also more likely to have unfavourable outcomes, including default (OR 2.85, 95%CI 1.81-4.49), death due to TB (OR 2.76, 95%CI 1.27-6.03) and death from other causes (OR 5.59, 95%CI 2.63-11.8). CONCLUSION: Our study highlights the challenges of using national registers for research into childhood TB.
Authors: Sampson Antwi; Hongmei Yang; Anthony Enimil; Anima M Sarfo; Fizza S Gillani; Daniel Ansong; Albert Dompreh; Antoinette Orstin; Theresa Opoku; Dennis Bosomtwe; Lubbe Wiesner; Jennifer Norman; Charles A Peloquin; Awewura Kwara Journal: Antimicrob Agents Chemother Date: 2017-01-24 Impact factor: 5.191