Ying Fang1, Xiaoxia Ren1, Zhanwei Feng2. 1. Department of Gastroenterology, Xi'an Children's Hospital Shaanxi 710002, China. 2. Department of Respiratory, Xi'an Children's Hospital Shaanxi 710002, China.
Abstract
OBJECTIVE: In order to explore the relevance of SOCS3 gene polymorphisms with infantile asthma and provide evidence for the ethology of infantile asthma, we conducted this case-control study. METHODS: A total of 273 children were enrolled for study in this article, including 119 children with asthma and 154 healthy controls frequency-matched with the former in sex and age. The genotyping of SOCS3 rs4969170, rs4969168 polymorphisms in all subjects were performed using TaqMan probe method. Odds ratio (OR) with 95% confidence interval (CI) was used to represent the association strength between SOCS3 polymorphisms and infantile asthma and calculated by χ² test which was conducted to check the Hardy-Weinberg equilibrium (HWE) in the control group. RESULTS: The genotypes distributions of SOCS3 polymorphisms in controls conformed to HWE. Compared with GG/GA genotype in SOCS3 rs4969170, AA genotype obviously increased the susceptibility to asthma in children (OR=2.556, 95% CI=1.377-4.744) and A allele also made the same conclusion (OR=2.287, 95% CI=1.311-3.991). Differently in rs4969168, AG and AG/GG genotypes distributions had significant differences in two groups (P=0.036, 0.043). This two polymorphisms existed the linkage disequilibrium and the haplotype analysis showed that A-G and A-A haplotypes in rs4969170-rs4969168 increased 1.855 and 0.863 times risk of asthma development in children, respectively. CONCLUSIONS: A significant relevance involved in SOCS3 gene polymorphisms and infantile asthma development based on a Chinese Han population.
OBJECTIVE: In order to explore the relevance of SOCS3 gene polymorphisms with infantile asthma and provide evidence for the ethology of infantile asthma, we conducted this case-control study. METHODS: A total of 273 children were enrolled for study in this article, including 119 children with asthma and 154 healthy controls frequency-matched with the former in sex and age. The genotyping of SOCS3rs4969170, rs4969168 polymorphisms in all subjects were performed using TaqMan probe method. Odds ratio (OR) with 95% confidence interval (CI) was used to represent the association strength between SOCS3 polymorphisms and infantile asthma and calculated by χ² test which was conducted to check the Hardy-Weinberg equilibrium (HWE) in the control group. RESULTS: The genotypes distributions of SOCS3 polymorphisms in controls conformed to HWE. Compared with GG/GA genotype in SOCS3rs4969170, AA genotype obviously increased the susceptibility to asthma in children (OR=2.556, 95% CI=1.377-4.744) and A allele also made the same conclusion (OR=2.287, 95% CI=1.311-3.991). Differently in rs4969168, AG and AG/GG genotypes distributions had significant differences in two groups (P=0.036, 0.043). This two polymorphisms existed the linkage disequilibrium and the haplotype analysis showed that A-G and A-A haplotypes in rs4969170-rs4969168 increased 1.855 and 0.863 times risk of asthma development in children, respectively. CONCLUSIONS: A significant relevance involved in SOCS3 gene polymorphisms and infantile asthma development based on a Chinese Han population.
Authors: E D Bateman; S S Hurd; P J Barnes; J Bousquet; J M Drazen; J M FitzGerald; P Gibson; K Ohta; P O'Byrne; S E Pedersen; E Pizzichini; S D Sullivan; S E Wenzel; H J Zar Journal: Eur Respir J Date: 2008-01 Impact factor: 16.671
Authors: Gary M Hunninghake; Manuel E Soto-Quirós; Jessica Lasky-Su; Lydiana Avila; Ngoc P Ly; Catherine Liang; Barbara J Klanderman; Benjamin A Raby; Diane R Gold; Scott T Weiss; Juan C Celedón Journal: J Allergy Clin Immunol Date: 2008-04-28 Impact factor: 10.793
Authors: Ilaria Puxeddu; Yun Yun Pang; Anna Harvey; Hans Michael Haitchi; Ben Nicholas; Hajime Yoshisue; Domenico Ribatti; Geraldine Clough; Rob M Powell; Gillian Murphy; Neil A Hanley; David I Wilson; Peter H Howarth; Stephen T Holgate; Donna E Davies Journal: J Allergy Clin Immunol Date: 2008-04-14 Impact factor: 10.793
Authors: Katharina Dinger; Philipp Kasper; Eva Hucklenbruch-Rother; Christina Vohlen; Eva Jobst; Ruth Janoschek; Inga Bae-Gartz; Silke van Koningsbruggen-Rietschel; Christian Plank; Jörg Dötsch; Miguel Angel Alejandre Alcázar Journal: Sci Rep Date: 2016-04-18 Impact factor: 4.379