Literature DB >> 26464713

Prognostic significance of microRNA-203 in cholangiocarcinoma.

Jingjing Li1, Beibei Gao2, Zufa Huang3, Tong Duan4, Daiqiang Li2, Sheng Zhang3, Yujun Zhao3, Lian Liu3, Qiang Wang3, Zhizhao Chen3, Ke Cheng3.   

Abstract

MircroRNA functions as a tumor suppressor or a promoter in cholangiocarcinoma (CCA). Researchers have found that miR-203 functioned as tumor suppressor in many types of cancer. However, the role of miR-203 that plays in CCA remains to be clarified. We aimed to detect the expression level and the prognostic significance of miR-203 in CCA tissues. qRT-RCR was performed to examine the miR-203 expression levels in CCA tissue specimens and corresponding normal tissues. Our findings suggest that miR-203 expression was an independent poor prognostic factor for CCA patient overall survival. Therefore, miR-203 may serve as a valuable prognostic marker and promising treatment target for CCA.

Entities:  

Keywords:  cholangiocarcinoma; miR-203; mircroRNA; prognosis

Mesh：

Substances：

Year:  2015        PMID： 26464713      PMCID： PMC4583945     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  18 in total

1.  Decreased expression of TFPI-2 correlated with increased expression of CD133 in cholangiocarcinoma.

Authors:  Xia Chu; Po Zhao; Yali Lv; Lin Liu
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

2.  miR-203 expression predicts outcome after liver transplantation for hepatocellular carcinoma in cirrhotic liver.

Authors:  Hong-Yuan Chen; Zhong-Bo Han; Jun-Wei Fan; Jun Xia; Jun-Yi Wu; Guo-Qiang Qiu; Hua-Mei Tang; Zhi-Hai Peng
Journal:  Med Oncol       Date:  2011-07-24       Impact factor: 3.064

3.  MiR-203 inhibits melanoma invasive and proliferative abilities by targeting the polycomb group gene BMI1.

Authors:  Xiao Chang; Yong Sun; Siqi Han; Wei Zhu; Haiping Zhang; Shi Lian
Journal:  Biochem Biophys Res Commun       Date:  2014-12-02       Impact factor: 3.575

4.  MicroRNA-195 functions as a tumor suppressor by inhibiting CBX4 in hepatocellular carcinoma.

Authors:  Changli Zheng; Jingjing Li; Qi Wang; Wei Liu; Jianda Zhou; Rui Liu; Qinghai Zeng; Xiaowei Peng; Chenghui Huang; Peiguo Cao; Ke Cao
Journal:  Oncol Rep       Date:  2015-01-19       Impact factor: 3.906

5.  miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.

Authors:  Tao Li; Feng Gao; Xi-Peng Zhang
Journal:  Oncol Rep       Date:  2014-12-04       Impact factor: 3.906

6.  The expression and function of microRNA-203 in lung cancer.

Authors:  Jianhua Jin; Jianzhong Deng; Fang Wang; Xiyi Xia; Tiefeng Qiu; Wenbin Lu; Xianwen Li; Hua Zhang; Xiaoyan Gu; Yungang Liu; Weiguo Cao; Wenlong Shao
Journal:  Tumour Biol       Date:  2012-10-17

7.  Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma.

Authors:  Takeo Nitta; Yasunori Sato; Xiang Shan Ren; Kenichi Harada; Motoko Sasaki; Satoshi Hirano; Yasuni Nakanuma
Journal:  Int J Clin Exp Pathol       Date:  2014-07-15

8.  MiR-203 controls proliferation, migration and invasive potential of prostate cancer cell lines.

Authors:  Giuditta Viticchiè; Anna Maria Lena; Alessia Latina; Amanda Formosa; Lea H Gregersen; Anders H Lund; Sergio Bernardini; Alessandro Mauriello; Roberto Miano; Luigi G Spagnoli; Richard A Knight; Eleonora Candi; Gerry Melino
Journal:  Cell Cycle       Date:  2011-04-01       Impact factor: 4.534

9.  MicroRNA-144 suppresses cholangiocarcinoma cell proliferation and invasion through targeting platelet activating factor acetylhydrolase isoform 1b.

Authors:  Rui Yang; Yongjun Chen; Cong Tang; Hongbo Li; Bing Wang; Qun Yan; Junbo Hu; Shengquan Zou
Journal:  BMC Cancer       Date:  2014-12-05       Impact factor: 4.430

10.  miR-203 inhibits cell proliferation and migration of lung cancer cells by targeting PKCα.

Authors:  Chen Wang; Xueliang Wang; Hongwei Liang; Tao Wang; Xin Yan; Minghui Cao; Nan Wang; Suyang Zhang; Ke Zen; Chenyu Zhang; Xi Chen
Journal:  PLoS One       Date:  2013-09-10       Impact factor: 3.240
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  8 in total

Review 1.  Targeting Angiogenesis in Biliary Tract Cancers: An Open Option.

Authors:  Valeria Simone; Oronzo Brunetti; Luigi Lupo; Mario Testini; Eugenio Maiorano; Michele Simone; Vito Longo; Christian Rolfo; Marc Peeters; Aldo Scarpa; Amalia Azzariti; Antonio Russo; Domenico Ribatti; Nicola Silvestris
Journal:  Int J Mol Sci       Date:  2017-02-15       Impact factor: 5.923

2.  miR-223-3p Inhibits Human Osteosarcoma Metastasis and Progression by Directly Targeting CDH6.

Authors:  Quanbo Ji; Xiaojie Xu; Qi Song; Yameng Xu; Yanhong Tai; Stuart B Goodman; Wenzhi Bi; Meng Xu; Shunchang Jiao; William J Maloney; Yan Wang
Journal:  Mol Ther       Date:  2018-03-14       Impact factor: 11.454

3.  Long non-coding RNA NNT-AS1 promotes cholangiocarcinoma cells proliferation and epithelial-to-mesenchymal transition through down-regulating miR-203.

Authors:  Yulei Gu; Zhiqiang Zhu; Hui Pei; Dong Xu; Yumin Jiang; Luanluan Zhang; Lili Xiao
Journal:  Aging (Albany NY)       Date:  2020-02-05       Impact factor: 5.682

4.  Aspirin inhibits cholangiocarcinoma cell proliferation via cell cycle arrest in vitro and in vivo.

Authors:  Tingting Shi; Jian Gong; Koji Fujita; Noriko Nishiyama; Hisakazu Iwama; Shi Liu; Mai Nakahara; Hirohito Yoneyama; Asahiro Morishita; Takako Nonura; Hideki Kobara; Keiichi Okano; Yasuyuki Suzuki; Tsutomu Masaki
Journal:  Int J Oncol       Date:  2020-12-30       Impact factor: 5.650

5.  MicroRNA-1182 and let-7a exert synergistic inhibition on invasion, migration and autophagy of cholangiocarcinoma cells through down-regulation of NUAK1.

Authors:  Xin Pan; Gang Wang; Baoming Wang
Journal:  Cancer Cell Int       Date:  2021-03-09       Impact factor: 5.722

Review 6.  miRNA and lncRNA as biomarkers in cholangiocarcinoma(CCA).

Authors:  Bo Zheng; Seogsong Jeong; Yanjing Zhu; Lei Chen; Qiang Xia
Journal:  Oncotarget       Date:  2017-07-06

7.  MicroRNA-203 predicts human survival after resection of colorectal liver metastasis.

Authors:  T Peter Kingham; Hoang C B Nguyen; Jian Zheng; Ioannis T Konstantinidis; Eran Sadot; Jinru Shia; Deborah Kuk; Steven Zhang; Leonard Saltz; Michael I D'Angelica; William R Jarnagin; Hani Goodarzi; Sohail F Tavazoie
Journal:  Oncotarget       Date:  2017-03-21

8.  Diagnostic and prognostic value of microRNAs in cholangiocarcinoma: a systematic review and meta-analysis.

Authors:  Chao Sun; Jie Zhu; Bin Wu; Jianlei Chen; Zhenwei Zhu; Peng Cai; Wanliang Guo; Zhicheng Gu; Jian Wang; Shungen Huang
Journal:  Cancer Manag Res       Date:  2018-07-18       Impact factor: 3.989
  8 in total

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