Zhongxue Su1, Juan Zhao1, Zhonghou Rong1, Wenmao Geng1, Zhiyi Wang1. 1. Department of Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jingwu Road, Jinan 250021, Shandong Province, China.
Abstract
BACKGROUND: The expression of microRNA-451 (miR-451) and its association with clinical pathological factors in GC remain still unclear. The purpose of this study was to investigate if miR-451 is a potential prognostic biomarker and tumor suppressor for gastric cancer. METHODS: Real-time quantitative RT-PCR (qRT-PCR) was applied to detect miR-451 expression in GC cell lines and primary tumor and paired non-cancerous tissues. The association of miR-451 expression with clinicopathological factors and prognosis was statistically analyzed. RESULTS: We found that miR-451 showed decreased expression in GC tissues and cell lines, and its down-regulation tended to be positively correlated with lymphatic metastasis, clinical staging and shorter overall survival of patients. In addition, forced expression of miR-451 in BGC-823 and MKN-45 cells did not impact on cell proliferation, but did reduce migration and invasion rates in BGC-823 cells. CONCLUSION: Our findings indicated that miR-451 may act as a novel prognostic marker and potential therapeutic target in human GC.
BACKGROUND: The expression of microRNA-451 (miR-451) and its association with clinical pathological factors in GC remain still unclear. The purpose of this study was to investigate if miR-451 is a potential prognostic biomarker and tumor suppressor for gastric cancer. METHODS: Real-time quantitative RT-PCR (qRT-PCR) was applied to detect miR-451 expression in GC cell lines and primary tumor and paired non-cancerous tissues. The association of miR-451 expression with clinicopathological factors and prognosis was statistically analyzed. RESULTS: We found that miR-451 showed decreased expression in GC tissues and cell lines, and its down-regulation tended to be positively correlated with lymphatic metastasis, clinical staging and shorter overall survival of patients. In addition, forced expression of miR-451 in BGC-823 and MKN-45 cells did not impact on cell proliferation, but did reduce migration and invasion rates in BGC-823 cells. CONCLUSION: Our findings indicated that miR-451 may act as a novel prognostic marker and potential therapeutic target in human GC.
Authors: Asta Varis; Maija Wolf; Outi Monni; Marja-Leena Vakkari; Arto Kokkola; Chris Moskaluk; Henry Frierson; Steven M Powell; Sakari Knuutila; Anne Kallioniemi; Wa'el El-Rifai Journal: Cancer Res Date: 2002-05-01 Impact factor: 12.701
Authors: Jakub Godlewski; Michal O Nowicki; Agnieszka Bronisz; Gerard Nuovo; Jeff Palatini; Michael De Lay; James Van Brocklyn; Michael C Ostrowski; E Antonio Chiocca; Sean E Lawler Journal: Mol Cell Date: 2010-03-12 Impact factor: 17.970
Authors: Malcolm A Moore; Sultan Eser; Nurbek Igisinov; Saginbek Igisinov; Mohammad Ali Mohagheghi; Alireza Mousavi-Jarrahi; Gülsün Ozentürk; Mashhura Soipova; Murat Tuncer; Tomotaka Sobue Journal: Asian Pac J Cancer Prev Date: 2010
Authors: Sergio Lario; Anna Brunet-Vega; María E Quílez; María J Ramírez-Lázaro; Juan J Lozano; Lorena García-Martínez; Carles Pericay; Mireia Miquel; Félix Junquera; Rafael Campo; Xavier Calvet Journal: United European Gastroenterol J Date: 2018-02-28 Impact factor: 4.623