Literature DB >> 25664140

Role of microRNAs in diagnosis and treatment of the pathogenesis of gastric cancer.

Gang Chen1, Yong Tang1, Jiang-Hua Wu2, Feng-Hua Liu2.   

Abstract

We aim to detect the miRNAs that are correlated with the gastric cancer cell line SGC-7901 to provide theoretical basis for clinical application. We first analyzed miRNA expression profiles of gastric cancer patients compared with normal controls by microarray analysis and validated the results by real-time qPCR. We also determined the absolute copy numbers of these three miRNAs in normal adults. The results showed that three miRNAs (miR-150, miR-23a, and miR-130a) were identified to significantly decrease in expanded 38 gastric cancer patients compared with 90 normal controls. Molecular and statistical analysis showed that the decreased miRNAs were significant in clinical analysis. Generally speaking, this finding suggest vital roles of these miRNAs in human gastric cancer genesis and as potential biomarkers in gastric cancer diagnosis.

Entities:  

Keywords:  SGC-7901; diagnosis biomarker; gastric cancer; microRNAs

Year:  2014        PMID： 25664140      PMCID： PMC4307587     

Source DB:  PubMed          Journal:  Int J Clin Exp Med        ISSN： 1940-5901


  39 in total

1.  miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151.

Authors:  Ronglin Zhai; Xuefeng Kan; Bo Wang; Hansong Du; Yueping Long; Heshui Wu; Kaixiong Tao; Guobin Wang; Lihong Bao; Fen Li; Wanli Zhang
Journal:  Tumour Biol       Date:  2014-08-15

2.  Similarly up-regulated microRNA-106a in matched formalin-fixed paraffin-embedded and fresh frozen samples and the dynamic changes during gastric carcinogenesis and development.

Authors:  Meng Zhu; Ning Zhang; Shuixiang He
Journal:  Pathol Res Pract       Date:  2014-07-30       Impact factor: 3.250

3.  MicroRNA-25 promotes gastric cancer migration, invasion and proliferation by directly targeting transducer of ERBB2, 1 and correlates with poor survival.

Authors:  B-S Li; Q-F Zuo; Y-L Zhao; B Xiao; Y Zhuang; X-H Mao; C Wu; S-M Yang; H Zeng; Q-M Zou; G Guo
Journal:  Oncogene       Date:  2014-07-21       Impact factor: 9.867

4.  GKN2 contributes to the homeostasis of gastric mucosa by inhibiting GKN1 activity.

Authors:  Olga Kim; Jung Hwan Yoon; Won Suk Choi; Hassan Ashktorab; Duane T Smoot; Suk Woo Nam; Jung Young Lee; Won Sang Park
Journal:  J Cell Physiol       Date:  2014-06       Impact factor: 6.384

5.  The microRNA-21/PTEN pathway regulates the sensitivity of HER2-positive gastric cancer cells to trastuzumab.

Authors:  Kojiro Eto; Masaaki Iwatsuki; Masayuki Watanabe; Satoshi Ida; Takatsugu Ishimoto; Shiro Iwagami; Yoshifumi Baba; Yasuo Sakamoto; Yuji Miyamoto; Naoya Yoshida; Hideo Baba
Journal:  Ann Surg Oncol       Date:  2013-10-24       Impact factor: 5.344

6.  MicroRNA-146a enhances Helicobacter pylori induced cell apoptosis in human gastric cancer epithelial cells.

Authors:  Kai Wu; Liu Yang; Cong Li; Chao-Hui Zhu; Xin Wang; Yi Yao; Yu-Jie Jia
Journal:  Asian Pac J Cancer Prev       Date:  2014

7.  Association of the hsa-mir-499 (rs3746444) polymorphisms with gastric cancer risk in the Chinese population.

Authors:  Xiao-Jin Wu; Yan-Yan Mi; Hui Yang; An-Kang Hu; Chen Li; Xiao-Dong Li; Qing-Guo Zhang
Journal:  Onkologie       Date:  2013-09-17

8.  A germline mutation in the miR‑125a coding region reduces miR‑125a expression and is associated with human gastric cancer.

Authors:  Hua Shang; Tao Wang; Feng Shang; Kun-Ming Huang; Yan-Qing Li
Journal:  Mol Med Rep       Date:  2014-08-04       Impact factor: 2.952

9.  Long noncoding RNA associated-competing endogenous RNAs in gastric cancer.

Authors:  Tian Xia; Qi Liao; Xiaoming Jiang; Yongfu Shao; Bingxiu Xiao; Yang Xi; Junming Guo
Journal:  Sci Rep       Date:  2014-08-15       Impact factor: 4.379

10.  Snail-regulated MiR-375 inhibits migration and invasion of gastric cancer cells by targeting JAK2.

Authors:  Yanjun Xu; Juan Jin; Yiman Liu; Zhenxia Huang; Yujie Deng; Tao You; Tianhua Zhou; Jianmin Si; Wei Zhuo
Journal:  PLoS One       Date:  2014-07-23       Impact factor: 3.240
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  7 in total

1.  MiR-451, a potential prognostic biomarker and tumor suppressor for gastric cancer.

Authors:  Zhongxue Su; Juan Zhao; Zhonghou Rong; Wenmao Geng; Zhiyi Wang
Journal:  Int J Clin Exp Pathol       Date:  2015-08-01

2.  Long-term follow-up after laparoscopic versus open distal gastrectomy for advanced gastric cancer.

Authors:  Ying Zhang; Fengxiang Qi; Yong Jiang; Haoyu Zhai; Yinglan Ji
Journal:  Int J Clin Exp Med       Date:  2015-08-15

Review 3.  Dysregulation of non-coding RNAs in gastric cancer.

Authors:  Qing Yang; Ren-Wen Zhang; Peng-Cheng Sui; Hai-Tao He; Lei Ding
Journal:  World J Gastroenterol       Date:  2015-10-21       Impact factor: 5.742

4.  Circulating MicroRNA-21, MicroRNA-23a, and MicroRNA-125b as Biomarkers for Diagnosis and Prognosis of Burkitt Lymphoma in Children.

Authors:  Jun Li; Xiao-Wen Zhai; Hong-Sheng Wang; Xiao-Wen Qian; Hui Miao; Xiao-Hua Zhu
Journal:  Med Sci Monit       Date:  2016-12-19

5.  MicroRNA-155 increases colon cancer chemoresistance to cisplatin by targeting forkhead box O3.

Authors:  Yuewen Gao; Zhaoyan Liu; Zhaohong Ding; Shicai Hou; Jun Li; Kehua Jiang
Journal:  Oncol Lett       Date:  2018-02-07       Impact factor: 2.967

6.  Dasatinib promotes TRAIL-mediated apoptosis by upregulating CHOP-dependent death receptor 5 in gastric cancer.

Authors:  Xiaona Wang; Qiang Xue; Liangliang Wu; Baogui Wang; Han Liang
Journal:  FEBS Open Bio       Date:  2018-03-23       Impact factor: 2.693

7.  FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p.

Authors:  Jinglin Zhang; Yuhang Zhou; Tingting Huang; Feng Wu; Yi Pan; Yujuan Dong; Yan Wang; Aden K Y Chan; Liping Liu; Johnny S H Kwan; Alvin H K Cheung; Chi Chun Wong; Angela K F Lo; Alfred S L Cheng; Jun Yu; Kwok Wai Lo; Wei Kang; Ka Fai To
Journal:  Oncogene       Date:  2018-08-06       Impact factor: 9.867
  7 in total

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