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Literature DB >> 26462441

Determination of the structure and morphology of gold nanoparticle-HSA protein complexes.

Robin Capomaccio¹, Isaac Ojea Jimenez, Pascal Colpo, Douglas Gilliland, Giacomo Ceccone, François Rossi, Luigi Calzolai.

Abstract

We propose a simple method to determine the structure and morphology of nanoparticle protein complexes. By combining a separation method with online size measurements, density measurements and circular dichroism, we could identify the number of proteins bound to each nanoparticle and their secondary structure changes in the complex. This method provides much-needed experimental information on the interaction of proteins with nanoparticles and on the behavior of nanoparticles in biological systems.

Mesh：

Substances：
Serum Albumin
Gold

Year: 2015 PMID： 26462441 DOI： 10.1039/c5nr05147a

Source DB: PubMed Journal: Nanoscale ISSN： 2040-3364 Impact factor: 7.790

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Cited

8 in total

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4. Quantification of the cellular dose and characterization of nanoparticle transport during in vitro testing.

Authors: Grigore Rischitor; Mariantonietta Parracino; Rita La Spina; Patricia Urbán; Isaac Ojea-Jiménez; Elena Bellido; Andrea Valsesia; Sabrina Gioria; Robin Capomaccio; Agnieszka Kinsner-Ovaskainen; Douglas Gilliland; François Rossi; Pascal Colpo
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5. Ongoing inflammation enhances the toxicity of engineered nanomaterials: Application of an in vitro co-culture model of the healthy and inflamed intestine.

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Determination of the structure and morphology of gold nanoparticle-HSA protein complexes.

1. Early Development Challenges for Drug Products Containing Nanomaterials.

Review 2. Sizing up the Next Generation of Nanomedicines.

3. Exploring the Interaction of Cobalt Oxide Nanoparticles with Albumin, Leukemia Cancer Cells and Pathogenic Bacteria by Multispectroscopic, Docking, Cellular and Antibacterial Approaches.

4. Quantification of the cellular dose and characterization of nanoparticle transport during in vitro testing.

5. Ongoing inflammation enhances the toxicity of engineered nanomaterials: Application of an in vitro co-culture model of the healthy and inflamed intestine.

Review 6. Tuning the immune system by nanoparticle-biomolecular corona.

7. Physicochemical Characterization Cascade of Nanoadjuvant-Antigen Systems for Improving Vaccines.

8. A Point-of-Care Immunosensor Based on a Quartz Crystal Microbalance with Graphene Biointerface for Antibody Assay.