Literature DB >> 26459309

Combination of genetic variants in cyclin D1 and retinoblastoma genes predict clinical outcome in oral cancer patients.

Abitha Murali1, Bipin T Varghese2, R Rejnish Kumar3, S Kannan4.   

Abstract

Oral cancer is a dreadful disease with a wide variation in geographical distribution. In order to identify some useful biomarkers for the disease prognosis, the present study assessed the influence of single nucleotide polymorphisms (SNPs) in cell cycle genes on survival in a well-annotated set of patients with oral squamous cell carcinoma (OSCC). The study examined 12 sequence variants or SNPs in selected cell cycle genes, with prognostic outcomes in 311 oral cancer patients. Our analysis showed that SNPs in cyclin D1:rs9344 and retinoblastoma:rs427686 genes showed a strong correlation with disease-free survival. In addition, the cumulative effect of these SNPs significantly and independently predicts the survival. Thus, the current study identified genotypes (SNP signature), which can be used as novel prognostic biomarkers to stratify patients based on disease-free survival and therefore maybe helpful in therapeutic decision-making.

Entities:  

Keywords:  Cell cycle; Oral cancer; Prognosis; Single nucleotide polymorphism

Mesh：

Substances：

Year:  2015        PMID： 26459309     DOI： 10.1007/s13277-015-4179-3

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  40 in total

1.  E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

Authors:  J R Nevins
Journal:  Science       Date:  1992-10-16       Impact factor: 47.728

2.  SNPStats: a web tool for the analysis of association studies.

Authors:  Xavier Solé; Elisabet Guinó; Joan Valls; Raquel Iniesta; Víctor Moreno
Journal:  Bioinformatics       Date:  2006-05-23       Impact factor: 6.937

Review 3.  Global epidemiology of oral and oropharyngeal cancer.

Authors:  Saman Warnakulasuriya
Journal:  Oral Oncol       Date:  2008-09-18       Impact factor: 5.337

4.  Molecular cloning and analysis of functional cDNA and genomic clones encoding bovine cellular retinoic acid-binding protein.

Authors:  H E Shubeita; J F Sambrook; A M McCormick
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

5.  p53, p21, Rb, and MDM2 proteins in tongue carcinoma from patients < 35 versus > 75 years.

Authors:  J A Regezi; N P Dekker; A McMillan; V Ramirez-Amador; A Meneses-Garcia; L M Ruiz-Godoy Rivera; E Chrysomali; I O Ng
Journal:  Oral Oncol       Date:  1999-07       Impact factor: 5.337

6.  Aberrant expression of cyclin D1 is associated with poor prognosis in early stage cervical cancer of the uterus.

Authors:  D S Bae; S B Cho; Y J Kim; J D Whang; S Y Song; C S Park; D S Kim; J H Lee
Journal:  Gynecol Oncol       Date:  2001-06       Impact factor: 5.482

7.  Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions.

Authors:  Yuanqing Ye; Scott M Lippman; J Jack Lee; Meng Chen; Marsha L Frazier; Margaret R Spitz; Xifeng Wu
Journal:  Cancer       Date:  2008-11-01       Impact factor: 6.860

Review 8.  Genetic polymorphisms and head and neck cancer outcomes: a review.

Authors:  Jessica Hopkins; David W Cescon; Darren Tse; Penelope Bradbury; Wei Xu; Clement Ma; Paul Wheatley-Price; John Waldron; David Goldstein; Francois Meyer; Isabelle Bairati; Geoffrey Liu
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-03       Impact factor: 4.254

Review 9.  Cell cycle dysregulation in oral cancer.

Authors:  R Todd; P W Hinds; K Munger; A K Rustgi; O G Opitz; Y Suliman; D T Wong
Journal:  Crit Rev Oral Biol Med       Date:  2002

10.  CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma.

Authors:  K M Sathyan; K R Nalinakumari; Thomas Abraham; S Kannan
Journal:  Oral Oncol       Date:  2007-12-03       Impact factor: 5.337
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  5 in total

1.  Association between genetic polymorphisms of long non-coding RNA PRNCR1 and prostate cancer risk in a sample of the Iranian population.

Authors:  Hedieh Sattarifard; Mohammad Hashemi; Shekoofeh Hassanzarei; Behzad Narouie; Gholamreza Bahari
Journal:  Mol Clin Oncol       Date:  2017-10-18

2.  Genetic variants of cell cycle pathway genes predict disease-free survival of hepatocellular carcinoma.

Authors:  Shun Liu; Tian-Bo Yang; Yue-Li Nan; An-Hua Li; Dong-Xiang Pan; Yang Xu; Shu Li; Ting Li; Xiao-Yun Zeng; Xiao-Qiang Qiu
Journal:  Cancer Med       Date:  2017-06-22       Impact factor: 4.452

3.  The impacts of single nucleotide polymorphisms in genes of cell cycle and NF-kB pathways on the efficacy and acute toxicities of radiotherapy in patients with nasopharyngeal carcinoma.

Authors:  Chengxian Guo; Yuling Huang; Jingjing Yu; Lijuan Liu; Xiaochang Gong; Min Huang; Chunling Jiang; Yulu Liao; Lihua Huang; Guoping Yang; Jingao Li
Journal:  Oncotarget       Date:  2017-04-11

4.  High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma.

Authors:  Qingyan Zhang; Danhui Huang; Zhenfei Zhang; Yuzhen Feng; Meiting Fu; Min Wei; Jueyu Zhou; Yuanjin Huang; Shuguang Liu; Rong Shi
Journal:  Oncol Rep       Date:  2018-10-12       Impact factor: 3.906

5.  Association between the HOTAIR polymorphisms and cancer risk: an updated meta-analysis.

Authors:  Zhao-Xiong Zhang; Xue Tong; Wan-Ni Zhang; Wei-Neng Fu
Journal:  Oncotarget       Date:  2017-01-17
  5 in total

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