Literature DB >> 26450697

Carbohydrate-Conjugated Hollow Oblate Mesoporous Silica Nanoparticles as Nanoantibiotics to Target Mycobacteria.

Nanjing Hao1, Xuan Chen1, Seaho Jeon1, Mingdi Yan1.   

Abstract

Engineering nanomaterials with enhanced antibacterial activities remains a critical and practical challenge. Hollow oblate mesoporous silica nanoparticles (HOMSNs) are synthesized by a simple protocol of ammonia hydrothermal treatment of oblate mesoporous silica nanoparticles prepared using dibenzyl ether as a cosolvent. When conjugated with trehalose as the targeting ligand, the antibiotic-encapsulated HOMSNs exhibit high binding affinity and antibacterial efficacy toward mycobacteria.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  antimicrobial; mesoporous silica nanoparticles; nanoantibiotics; targeting; trehalose

Mesh：

Substances：

Year:  2015        PMID： 26450697      PMCID： PMC4701626          DOI： 10.1002/adhm.201500491

Source DB:  PubMed          Journal:  Adv Healthc Mater        ISSN： 2192-2640            Impact factor:   9.933


  39 in total

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Review 6.  Therapeutic strategies to combat antibiotic resistance.

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9.  Trehalose is required for growth of Mycobacterium smegmatis.

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  15 in total

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Review 4.  Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?

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5.  Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.

Authors:  Xuan Chen; Bin Wu; Kalana W Jayawardana; Nanjing Hao; H Surangi N Jayawardena; Robert Langer; Ana Jaklenec; Mingdi Yan
Journal:  Adv Healthc Mater       Date:  2016-06-10       Impact factor: 9.933

6.  Synthesis and Structure-Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens.

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7.  Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular Staphylococcus aureus.

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Journal:  ACS Appl Bio Mater       Date:  2019-02-14

Review 8.  Harnessing molecular recognition for localized drug delivery.

Authors:  Renjie Liu; Ran Zuo; Gregory A Hudalla
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Review 9.  Nanoantibiotics: Functions and Properties at the Nanoscale to Combat Antibiotic Resistance.

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Journal:  Front Chem       Date:  2021-05-13       Impact factor: 5.221

Review 10.  Hollow structures as drug carriers: Recognition, response, and release.

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