D Pareto1, J Sastre-Garriga2, C Auger1, Y Vives-Gilabert3, J Delgado3, M Tintoré2, X Montalban2, A Rovira4. 1. From Unitat de Ressonància Magnètica (IDI), Servei de Radiologia (D.P., C.A., A.R.). 2. Servei de Neurologia/Neuroimmunologia, Multiple Sclerosis Centre of Catalonia (Cemcat) (J.S.-G., M.T., X.M.). 3. Hospital Universitari Vall d'Hebron, and Port d'Informació Científica (Y.V.-G., J.D.), Universitat Autònoma de Barcelona, Barcelona, Spain. 4. From Unitat de Ressonància Magnètica (IDI), Servei de Radiologia (D.P., C.A., A.R.) alex.rovira@idi.gencat.cat.
Abstract
BACKGROUND AND PURPOSE: The role of juxtacortical lesions in brain volume loss in multiple sclerosis has not been fully clarified. The aim of this study was to explore the role of juxtacortical lesions on cortical atrophy and to investigate whether the presence of juxtacortical lesions is related to local cortical thinning in the early stages of MS. MATERIALS AND METHODS: A total of 131 patients with clinically isolated syndrome or with relapsing-remitting MS were scanned on a 3T system. Patients with clinically isolated syndrome were classified into 3 groups based on the presence and topography of brain lesions: no lesions (n = 24), only non-juxtacortical lesions (n = 33), and juxtacortical lesions and non-juxtacortical lesions (n = 34). Patients with relapsing-remitting MS were classified into 2 groups: only non-juxtacortical lesions (n = 10) and with non-juxtacortical lesions and juxtacortical lesions (n = 30). A juxtacortical lesion probability map was generated, and cortical thickness was measured by using FreeSurfer. RESULTS: Juxtacortical lesion volume in relapsing-remitting MS was double that of patients with clinically isolated syndrome. The insula showed the highest density of juxtacortical lesions, followed by the temporal, parietal, frontal, and occipital lobes. Patients with relapsing-remitting MS with juxtacortical lesions showed significantly thinner cortices overall and in the parietal and temporal lobes compared with those with clinically isolated syndrome with normal brain MR imaging. The volume of subcortical structures (thalamus, pallidum, putamen, and accumbens) was significantly decreased in relapsing-remitting MS with juxtacortical lesions compared with clinically isolated syndrome with normal brain MR imaging. The spatial distribution of juxtacortical lesions was not found to overlap with areas of cortical thinning. CONCLUSIONS: Cortical thinning and subcortical gray matter volume loss in patients with a clinically isolated syndrome or relapsing-remitting MS was related to the presence of juxtacortical lesions, though the cortical areas with the most marked thinning did not correspond to those with the largest number of juxtacortical lesions.
BACKGROUND AND PURPOSE: The role of juxtacortical lesions in brain volume loss in multiple sclerosis has not been fully clarified. The aim of this study was to explore the role of juxtacortical lesions on cortical atrophy and to investigate whether the presence of juxtacortical lesions is related to local cortical thinning in the early stages of MS. MATERIALS AND METHODS: A total of 131 patients with clinically isolated syndrome or with relapsing-remitting MS were scanned on a 3T system. Patients with clinically isolated syndrome were classified into 3 groups based on the presence and topography of brain lesions: no lesions (n = 24), only non-juxtacortical lesions (n = 33), and juxtacortical lesions and non-juxtacortical lesions (n = 34). Patients with relapsing-remitting MS were classified into 2 groups: only non-juxtacortical lesions (n = 10) and with non-juxtacortical lesions and juxtacortical lesions (n = 30). A juxtacortical lesion probability map was generated, and cortical thickness was measured by using FreeSurfer. RESULTS: Juxtacortical lesion volume in relapsing-remitting MS was double that of patients with clinically isolated syndrome. The insula showed the highest density of juxtacortical lesions, followed by the temporal, parietal, frontal, and occipital lobes. Patients with relapsing-remitting MS with juxtacortical lesions showed significantly thinner cortices overall and in the parietal and temporal lobes compared with those with clinically isolated syndrome with normal brain MR imaging. The volume of subcortical structures (thalamus, pallidum, putamen, and accumbens) was significantly decreased in relapsing-remitting MS with juxtacortical lesions compared with clinically isolated syndrome with normal brain MR imaging. The spatial distribution of juxtacortical lesions was not found to overlap with areas of cortical thinning. CONCLUSIONS: Cortical thinning and subcortical gray matter volume loss in patients with a clinically isolated syndrome or relapsing-remitting MS was related to the presence of juxtacortical lesions, though the cortical areas with the most marked thinning did not correspond to those with the largest number of juxtacortical lesions.
Authors: N Tzourio-Mazoyer; B Landeau; D Papathanassiou; F Crivello; O Etard; N Delcroix; B Mazoyer; M Joliot Journal: Neuroimage Date: 2002-01 Impact factor: 6.556
Authors: Massimo Filippi; Maria A Rocca; Frederik Barkhof; Wolfgang Brück; Jacqueline T Chen; Giancarlo Comi; Gabriele DeLuca; Nicola De Stefano; Bradley J Erickson; Nikos Evangelou; Franz Fazekas; Jeroen J G Geurts; Claudia Lucchinetti; David H Miller; Daniel Pelletier; Bogdan F Gh Popescu; Hans Lassmann Journal: Lancet Neurol Date: 2012-03-19 Impact factor: 44.182
Authors: Arnaud Charil; Alain Dagher; Jason P Lerch; Alex P Zijdenbos; Keith J Worsley; Alan C Evans Journal: Neuroimage Date: 2006-11-16 Impact factor: 6.556
Authors: Alexandra Kutzelnigg; Claudia F Lucchinetti; Christine Stadelmann; Wolfgang Brück; Helmut Rauschka; Markus Bergmann; Manfred Schmidbauer; Joseph E Parisi; Hans Lassmann Journal: Brain Date: 2005-10-17 Impact factor: 13.501
Authors: Jeroen J G Geurts; Erwin L A Blezer; Hugo Vrenken; Annette van der Toorn; Jonas A Castelijns; Chris H Polman; Petra J W Pouwels; Lars Bö; Frederik Barkhof Journal: J Neurol Date: 2008-02-04 Impact factor: 4.849
Authors: Michael Sailer; Bruce Fischl; David Salat; Claus Tempelmann; Mircea Ariel Schönfeld; Evelina Busa; Nils Bodammer; Hans-Jochen Heinze; Anders Dale Journal: Brain Date: 2003-06-04 Impact factor: 13.501
Authors: Erin S Beck; Josefina Maranzano; Nicholas J Luciano; Prasanna Parvathaneni; Stefano Filippini; Mark Morrison; Daniel J Suto; Tianxia Wu; Peter van Gelderen; Jacco A de Zwart; Samson Antel; Dumitru Fetco; Joan Ohayon; Frances Andrada; Yair Mina; Chevaz Thomas; Steve Jacobson; Jeff Duyn; Irene Cortese; Sridar Narayanan; Govind Nair; Pascal Sati; Daniel S Reich Journal: Mult Scler Date: 2022-02-10 Impact factor: 5.855
Authors: Tobias Granberg; Qiuyun Fan; Constantina Andrada Treaba; Russell Ouellette; Elena Herranz; Gabriel Mangeat; Céline Louapre; Julien Cohen-Adad; Eric C Klawiter; Jacob A Sloane; Caterina Mainero Journal: Brain Date: 2017-11-01 Impact factor: 13.501
Authors: A D Mulholland; R Vitorino; S-P Hojjat; A Y Ma; L Zhang; L Lee; T J Carroll; C G Cantrell; C R Figley; R I Aviv Journal: AJNR Am J Neuroradiol Date: 2017-11-02 Impact factor: 3.825
Authors: Massimo Filippi; Paolo Preziosa; Brenda L Banwell; Frederik Barkhof; Olga Ciccarelli; Nicola De Stefano; Jeroen J G Geurts; Friedemann Paul; Daniel S Reich; Ahmed T Toosy; Anthony Traboulsee; Mike P Wattjes; Tarek A Yousry; Achim Gass; Catherine Lubetzki; Brian G Weinshenker; Maria A Rocca Journal: Brain Date: 2019-07-01 Impact factor: 13.501
Authors: Lorenzo Gaetani; Kina Höglund; Lucilla Parnetti; Fani Pujol-Calderon; Bruno Becker; Paolo Eusebi; Paola Sarchielli; Paolo Calabresi; Massimiliano Di Filippo; Henrik Zetterberg; Kaj Blennow Journal: Alzheimers Res Ther Date: 2018-01-23 Impact factor: 6.982