A D Mulholland1, R Vitorino1, S-P Hojjat1, A Y Ma1, L Zhang1,2, L Lee3, T J Carroll4, C G Cantrell5, C R Figley6, R I Aviv7,8. 1. From the Department of Physical Sciences (A.D.M., R.V., S.-P.H., A.Y.M., L.Z.), Sunnybrook Research Institute, Toronto, Ontario, Canada. 2. Departments of Medical Imaging (L.Z., R.I.A.). 3. Neurology (L.L.), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 4. Department of Biomedical Engineering and Radiology (T.J.C.), University of Chicago, Chicago, Illinois. 5. Department of Biomedical Engineering (C.G.C.), Northwestern University, Chicago, Illinois. 6. Department of Radiology and Biomedical Engineering (C.R.F.), University of Manitoba, Winnipeg, Manitoba, Canada. 7. Departments of Medical Imaging (L.Z., R.I.A.) Richard.aviv@sunnybrook.ca. 8. Department of Medical Imaging (R.I.A.), University of Toronto, Toronto, Ontario, Canada.
Abstract
BACKGROUND AND PURPOSE: The spatial correlation between WM and cortical GM disease in multiple sclerosis is controversial and has not been previously assessed with perfusion MR imaging. We sought to determine the nature of association between lobar WM, cortical GM, volume and perfusion. MATERIALS AND METHODS: Nineteen individuals with secondary-progressive multiple sclerosis, 19 with relapsing-remitting multiple sclerosis, and 19 age-matched healthy controls were recruited. Quantitative MR perfusion imaging was used to derive CBF, CBV, and MTT within cortical GM, WM, and T2-hyperintense lesions. A 2-step multivariate linear regression (corrected for age, disease duration, and Expanded Disability Status Scale) was used to assess correlations between perfusion and volume measures in global and lobar normal-appearing WM, cortical GM, and T2-hyperintense lesions. The Bonferroni adjustment was applied as appropriate. RESULTS: Global cortical GM and WM volume was significantly reduced for each group comparison, except cortical GM volume of those with relapsing-remitting multiple sclerosis versus controls. Global and lobar cortical GM CBF and CBV were reduced in secondary-progressive multiple sclerosis compared with other groups but not for relapsing-remitting multiple sclerosis versus controls. Global and lobar WM CBF and CBV were not significantly different across groups. The distribution of lobar cortical GM and WM volume reduction was disparate, except for the occipital lobes in patients with secondary-progressive multiple sclerosis versus those with relapsing-remitting multiple sclerosis. Moderate associations were identified between lobar cortical GM and lobar normal-appearing WM volume in controls and in the left temporal lobe in relapsing-remitting multiple sclerosis. No significant associations occurred between cortical GM and WM perfusion or volume. Strong correlations were observed between cortical-GM perfusion, normal appearing WM and lesional perfusion, with respect to each global and lobar region within HC, and RRMS and SPMS patients (R2 ≤ 0.96, P < .006 and R2 ≤ 0.738, P < .006). CONCLUSIONS: The weak correlation between lobar WM and cortical GM volume loss and perfusion reduction suggests the independent pathophysiology of WM and cortical GM disease.
BACKGROUND AND PURPOSE: The spatial correlation between WM and cortical GM disease in multiple sclerosis is controversial and has not been previously assessed with perfusion MR imaging. We sought to determine the nature of association between lobar WM, cortical GM, volume and perfusion. MATERIALS AND METHODS: Nineteen individuals with secondary-progressive multiple sclerosis, 19 with relapsing-remitting multiple sclerosis, and 19 age-matched healthy controls were recruited. Quantitative MR perfusion imaging was used to derive CBF, CBV, and MTT within cortical GM, WM, and T2-hyperintense lesions. A 2-step multivariate linear regression (corrected for age, disease duration, and Expanded Disability Status Scale) was used to assess correlations between perfusion and volume measures in global and lobar normal-appearing WM, cortical GM, and T2-hyperintense lesions. The Bonferroni adjustment was applied as appropriate. RESULTS: Global cortical GM and WM volume was significantly reduced for each group comparison, except cortical GM volume of those with relapsing-remitting multiple sclerosis versus controls. Global and lobar cortical GM CBF and CBV were reduced in secondary-progressive multiple sclerosis compared with other groups but not for relapsing-remitting multiple sclerosis versus controls. Global and lobar WM CBF and CBV were not significantly different across groups. The distribution of lobar cortical GM and WM volume reduction was disparate, except for the occipital lobes in patients with secondary-progressive multiple sclerosis versus those with relapsing-remitting multiple sclerosis. Moderate associations were identified between lobar cortical GM and lobar normal-appearing WM volume in controls and in the left temporal lobe in relapsing-remitting multiple sclerosis. No significant associations occurred between cortical GM and WM perfusion or volume. Strong correlations were observed between cortical-GM perfusion, normal appearing WM and lesional perfusion, with respect to each global and lobar region within HC, and RRMS and SPMS patients (R2 ≤ 0.96, P < .006 and R2 ≤ 0.738, P < .006). CONCLUSIONS: The weak correlation between lobar WM and cortical GM volume loss and perfusion reduction suggests the independent pathophysiology of WM and cortical GM disease.
Authors: Seyed-Parsa Hojjat; Charles Grady Cantrell; Rita Vitorino; Anthony Feinstein; Zahra Shirzadi; Bradley J MacIntosh; David E Crane; Lying Zhang; Sarah A Morrow; Liesly Lee; Paul O'Connor; Timothy J Carroll; Richard I Aviv Journal: Mult Scler Date: 2016-01-11 Impact factor: 6.312
Authors: Maulin K Shah; Wanyong Shin; Vishal S Parikh; Ann Ragin; Jessy Mouannes; Richard A Bernstein; Matthew T Walker; Hem Bhatt; Timothy J Carroll Journal: J Magn Reson Imaging Date: 2010-10 Impact factor: 4.813
Authors: Laëtitia Debernard; Tracy R Melzer; Saskia Van Stockum; Charlotte Graham; Claudia Am Wheeler-Kingshott; John C Dalrymple-Alford; David H Miller; Deborah F Mason Journal: J Neurol Neurosurg Psychiatry Date: 2013-09-13 Impact factor: 10.154
Authors: Monroe P Turner; Nicholas A Hubbard; Dinesh K Sivakolundu; Lyndahl M Himes; Joanna L Hutchison; John Hart; Jeffrey S Spence; Elliot M Frohman; Teresa C Frohman; Darin T Okuda; Bart Rypma Journal: Neuroimage Date: 2018-02-15 Impact factor: 6.556