Majid Gholami-Ahangaran1, Nader Rangsaz2, Shahrzad Azizi3. 1. a 1 Department of Poultry Diseases , Veterinary Medicine Faculty, Shahrekord Branch, Islamic Azad University , Shahrekord , Iran . 2. b 2 Young Researchers Club, Veterinary Medicine Faculty, Shahrekord Branch, Islamic Azad University , Shahrekord , Iran , and. 3. c 3 Department of Pathobiology , Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman , Kerman , Iran.
Abstract
CONTEXT: Aflatoxins as potent mycotoxins can influence vital parameters in chickens. Turmeric was used in decreasing toxic effect of mycotoxins on vital organs, traditionally. OBJECTIVE: The study compared the protective effect of turmeric and Mycoad(TR) in broilers exposed to aflatoxin. MATERIALS AND METHODS: Chickens (270) were divided into six groups. The chickens were fed a basal diet, turmeric extract (5 mg/kg diet), Mycoad(TR) (25 mg/kg diet), productive aflatoxin (3 mg/kg diet), aflatoxin plus turmeric extract (3 versus 5 mg/kg diet), and aflatoxin plus Mycoad(TR) (3 versus 25 mg/kg diet) in basal diet. At 28 d old, we determined plasma concentration of total protein, albumin, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), calcium, potassium, phosphorous, uric acid, aspartate transferase (AST), and alanine aminotransferase (ALT). Furthermore, liver and kidney were sampled for pathological examination. RESULTS: Chickens fed turmeric with aflatoxin had significant lower ALT, AST, and uric acid than chickens fed aflatoxin (11.4 ± 0.79, 228 ± 9, and 6 ± 0.4 versus 17.2 ± 1.7, 283 ± 5, and 7.7 ± 0.1) whereas, total protein, calcium, and HDL values in chickens fed aflatoxin plus turmeric increased significantly (2.66 ± 0.16, 8.4 ± 0.2, and 920 ± 4.1 versus 1.7 ± 0.17, 7 ± 0.2, and 690 ± 4.8). Pathological examination revealed severe congestion, degeneration, and necrosis in liver and kidney in chickens that received aflatoxin. DISCUSSION AND CONCLUSION: The study showed that turmeric may provide protection against the toxic effects of aflatoxin on liver and kidney.
CONTEXT: Aflatoxins as potent mycotoxins can influence vital parameters in chickens. Turmeric was used in decreasing toxic effect of mycotoxins on vital organs, traditionally. OBJECTIVE: The study compared the protective effect of turmeric and Mycoad(TR) in broilers exposed to aflatoxin. MATERIALS AND METHODS:Chickens (270) were divided into six groups. The chickens were fed a basal diet, turmeric extract (5 mg/kg diet), Mycoad(TR) (25 mg/kg diet), productive aflatoxin (3 mg/kg diet), aflatoxin plus turmeric extract (3 versus 5 mg/kg diet), and aflatoxin plus Mycoad(TR) (3 versus 25 mg/kg diet) in basal diet. At 28 d old, we determined plasma concentration of total protein, albumin, triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), calcium, potassium, phosphorous, uric acid, aspartate transferase (AST), and alanine aminotransferase (ALT). Furthermore, liver and kidney were sampled for pathological examination. RESULTS:Chickens fed turmeric with aflatoxin had significant lower ALT, AST, and uric acid than chickens fed aflatoxin (11.4 ± 0.79, 228 ± 9, and 6 ± 0.4 versus 17.2 ± 1.7, 283 ± 5, and 7.7 ± 0.1) whereas, total protein, calcium, and HDL values in chickens fed aflatoxin plus turmeric increased significantly (2.66 ± 0.16, 8.4 ± 0.2, and 920 ± 4.1 versus 1.7 ± 0.17, 7 ± 0.2, and 690 ± 4.8). Pathological examination revealed severe congestion, degeneration, and necrosis in liver and kidney in chickens that received aflatoxin. DISCUSSION AND CONCLUSION: The study showed that turmeric may provide protection against the toxic effects of aflatoxin on liver and kidney.
Authors: Aya Ashry; Nabil M Taha; Mohamed A Lebda; Walied Abdo; Eman M El-Diasty; Sabreen E Fadl; Mohamed Morsi Elkamshishi Journal: BMC Vet Res Date: 2022-05-14 Impact factor: 2.792
Authors: Bruno Solis-Cruz; Daniel Hernandez-Patlan; Victor M Petrone; Karine P Pontin; Juan D Latorre; Eric Beyssac; Xochitl Hernandez-Velasco; Ruben Merino-Guzman; Casey Owens; Billy M Hargis; Raquel Lopez-Arellano; Guillermo Tellez-Isaias Journal: Toxins (Basel) Date: 2019-02-16 Impact factor: 4.546