BACKGROUND: There are large data gaps in the epidemiology of diseases caused by Salmonella enterica in West Africa. Regional surveillance of Salmonella infections is necessary, especially with the emergence and spread of multidrug-resistant clones. METHODS: Data on Salmonella isolated from various clinical specimens from patients from across The Gambia were collected and analyzed retrospectively from 2005 to April 2015. Antibiotic sensitivity testing of Salmonella isolates was performed by disk diffusion method. Serotyping and serogrouping of Salmonella isolates was performed using standard microbiology techniques. RESULTS: Two hundred three Salmonella isolates were isolated from 190 patients: 52% (106/203) from blood and 39% (79/203) from stool specimens. Salmonella was also isolated from urine, aspirates, cerebrospinal fluid, wounds, and abscesses. The prevalence of Salmonella in blood cultures was 0.8% (106/13,905). Of the serotyped salmonellae, 14% (21/152) were Salmonella enterica serovar Typhi, whereas 86% (131/152) were serovars other than Typhi (nontyphoidal Salmonella). Of the 102 typed NTS isolates, 40% (41) were Salmonella enterica serovar Typhimurium, 10% (10) were Salmonella enterica serovar Enteritidis, and 3% (3) were Salmonella enterica serovar Arizonae. Overall, 70% (142/203) of the salmonellae were pansusceptible. Multidrug resistance was found in 4% (9/203) of the isolates, 3 of which were Salmonella Enteritidis. CONCLUSIONS: Salmonellae are associated with a wide spectrum of invasive and noninvasive infections across all ages in The Gambia. There is evidence of multidrug resistance in salmonellae that warrants vigilant monitoring and surveillance.
BACKGROUND: There are large data gaps in the epidemiology of diseases caused by Salmonella enterica in West Africa. Regional surveillance of Salmonella infections is necessary, especially with the emergence and spread of multidrug-resistant clones. METHODS: Data on Salmonella isolated from various clinical specimens from patients from across The Gambia were collected and analyzed retrospectively from 2005 to April 2015. Antibiotic sensitivity testing of Salmonella isolates was performed by disk diffusion method. Serotyping and serogrouping of Salmonella isolates was performed using standard microbiology techniques. RESULTS: Two hundred three Salmonella isolates were isolated from 190 patients: 52% (106/203) from blood and 39% (79/203) from stool specimens. Salmonella was also isolated from urine, aspirates, cerebrospinal fluid, wounds, and abscesses. The prevalence of Salmonella in blood cultures was 0.8% (106/13,905). Of the serotyped salmonellae, 14% (21/152) were Salmonella enterica serovar Typhi, whereas 86% (131/152) were serovars other than Typhi (nontyphoidal Salmonella). Of the 102 typed NTS isolates, 40% (41) were Salmonella enterica serovar Typhimurium, 10% (10) were Salmonella enterica serovar Enteritidis, and 3% (3) were Salmonella enterica serovar Arizonae. Overall, 70% (142/203) of the salmonellae were pansusceptible. Multidrug resistance was found in 4% (9/203) of the isolates, 3 of which were Salmonella Enteritidis. CONCLUSIONS: Salmonellae are associated with a wide spectrum of invasive and noninvasive infections across all ages in The Gambia. There is evidence of multidrug resistance in salmonellae that warrants vigilant monitoring and surveillance.
Authors: Saffiatou Darboe; Richard S Bradbury; Jody Phelan; Abdoulie Kanteh; Abdul-Khalie Muhammad; Archibald Worwui; Shangxin Yang; Davis Nwakanma; Blanca Perez-Sepulveda; Samuel Kariuki; Brenda Kwambana-Adams; Martin Antonio Journal: Microb Genom Date: 2022-03
Authors: Ebenezer Foster-Nyarko; Brenda Kwambana; Fatima Ceesay; Kaddijatou Jawneh; Saffiatou Darboe; Sarah N Mulwa; Buntung Ceesay; Ousman O Secka; Ifedayo Adetifa; Martin Antonio Journal: BMC Res Notes Date: 2017-02-23
Authors: Heidi Hopkins; Katia J Bruxvoort; Matthew E Cairns; Clare I R Chandler; Baptiste Leurent; Evelyn K Ansah; Frank Baiden; Kimberly A Baltzell; Anders Björkman; Helen E D Burchett; Siân E Clarke; Deborah D DiLiberto; Kristina Elfving; Catherine Goodman; Kristian S Hansen; S Patrick Kachur; Sham Lal; David G Lalloo; Toby Leslie; Pascal Magnussen; Lindsay Mangham Jefferies; Andreas Mårtensson; Ismail Mayan; Anthony K Mbonye; Mwinyi I Msellem; Obinna E Onwujekwe; Seth Owusu-Agyei; Hugh Reyburn; Mark W Rowland; Delér Shakely; Lasse S Vestergaard; Jayne Webster; Virginia L Wiseman; Shunmay Yeung; David Schellenberg; Sarah G Staedke; Christopher J M Whitty Journal: BMJ Date: 2017-03-29
Authors: Pa Saidou Chaw; Kristin Maria Schlinkmann; Heike Raupach-Rosin; André Karch; Mathias W Pletz; Johannes Huebner; Ousman Nyan; Rafael Mikolajczyk Journal: Antimicrob Resist Infect Control Date: 2018-07-16 Impact factor: 4.887
Authors: Léa Luciani; Grégory Dubourg; Thomas Graillon; Estelle Honnorat; Hubert Lepidi; Michel Drancourt; Piseth Seng; Andreas Stein Journal: J Med Case Rep Date: 2016-07-07
Authors: Calman A MacLennan; Chisomo L Msefula; Esther N Gondwe; James J Gilchrist; Paul Pensulo; Wilson L Mandala; Grace Mwimaniwa; Meraby Banda; Julia Kenny; Lorna K Wilson; Amos Phiri; Jenny M MacLennan; Elizabeth M Molyneux; Malcolm E Molyneux; Stephen M Graham Journal: PLoS Negl Trop Dis Date: 2017-12-07