Literature DB >> 26440560

Rhodium-Catalyzed C-H Alkylation of Indolines with Allylic Alcohols: Direct Access to β-Aryl Carbonyl Compounds.

Sang Hoon Han1, Miji Choi1, Taejoo Jeong1, Satyasheel Sharma1, Neeraj Kumar Mishra1, Jihye Park1, Joa Sub Oh2,3, Woo Jung Kim3, Jong Suk Lee3, In Su Kim1.   

Abstract

The rhodium(III)-catalyzed site-selective C-H alkylation of various N-heterocycles, such as indolines, carbazoles, and pyrroles with readily available allylic alcohols is described. This protocol allows the generation of a heterocyclic scaffold containing a β-aryl carbonyl moiety, which is known to be a crucial structural unit of biologically active compounds.

Entities:  

Year:  2015        PMID: 26440560     DOI: 10.1021/acs.joc.5b01696

Source DB:  PubMed          Journal:  J Org Chem        ISSN: 0022-3263            Impact factor:   4.354


  4 in total

1.  Convergent Synthesis of Diverse Nitrogen Heterocycles via Rh(III)-Catalyzed C-H Conjugate Addition/Cyclization Reactions.

Authors:  Adam B Weinstein; Jonathan A Ellman
Journal:  Org Lett       Date:  2016-06-23       Impact factor: 6.005

2.  Rhodium(iii)-catalyzed C-H allylation of indoles with allyl alcohols via β-hydroxide elimination.

Authors:  Xiaowei Wu; Haitao Ji
Journal:  Org Biomol Chem       Date:  2018-08-08       Impact factor: 3.876

3.  Rh(iii)-catalyzed C-7 arylation of indolines with arylsilanes via C-H activation.

Authors:  Haiqing Luo; Qi Xie; Kai Sun; Jianbo Deng; Lin Xu; Kejun Wang; Xuzhong Luo
Journal:  RSC Adv       Date:  2019-06-10       Impact factor: 4.036

4.  Carboxylate-directed C-H allylation with allyl alcohols or ethers.

Authors:  Xiao-Qiang Hu; Zhiyong Hu; A Stefania Trita; Guodong Zhang; Lukas J Gooßen
Journal:  Chem Sci       Date:  2018-05-21       Impact factor: 9.825

  4 in total

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