Literature DB >> 26439959

Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis.

Adeline S L Ng1, Joel Kramer1, Alejandro Centurion2, Josep Dalmau3, Eric Huang4, Jennifer A Cotter4, Michael D Geschwind5.   

Abstract

Autoantibodies associated with autoimmune limbic encephalitis (ALE) have been well-characterized, with intracellular neuronal antibodies being less responsive to immunotherapy than antibodies to cell surface antigens. Adenylate kinase 5 (AK5) is a nucleoside monophosphate kinase vital for neuronal-specific metabolism and is located intracellularly in the cytosol and expressed exclusively in the brain. Antibodies to AK5 had been previously identified but were not known to be associated with human disease prior to the report of two patients with AK5-related ALE (Tuzun et al., 2007). We present the complete clinical picture for one of these patients and the first reported neuropathology for AK5 ALE.
Copyright © 2015. Published by Elsevier B.V.

Entities:  

Keywords:  Adenylate kinase 5; Autoimmunity; Limbic encephalitis; Neuronal antibodies; Rapidly progressive dementia

Mesh：

Substances：

Year:  2015        PMID： 26439959      PMCID： PMC4879958          DOI： 10.1016/j.jneuroim.2015.08.009

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  15 in total

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Authors:  Petras P Dzeja; Ryan Bortolon; Carmen Perez-Terzic; Ekshon L Holmuhamedov; Andre Terzic
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-15       Impact factor: 11.205

2.  Limbic encephalitis: extension of the diagnostic armamentarium.

Authors:  Christian G Bien
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-10-03       Impact factor: 10.154

3.  Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomes.

Authors:  L Bataller; K A Kleopa; G F Wu; J E Rossi; M R Rosenfeld; J Dalmau
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-09-15       Impact factor: 10.154

4.  Protein kinase Cgamma autoimmunity in paraneoplastic cerebellar degeneration and non-small-cell lung cancer.

Authors:  L Sabater; L Bataller; A F Carpentier; M L Aguirre-Cruz; A Saiz; B Benyahia; J Dalmau; F Graus
Journal:  J Neurol Neurosurg Psychiatry       Date:  2006-06-26       Impact factor: 10.154

5.  Identification of a novel human adenylate kinase. cDNA cloning, expression analysis, chromosome localization and characterization of the recombinant protein.

Authors:  A R Van Rompay; M Johansson; A Karlsson
Journal:  Eur J Biochem       Date:  1999-04

6.  CSF cyclic AMP and CSF adenylate kinase in cerebral ischaemic infarction.

Authors:  T Büttner; C R Hornig; O Busse; W Dorndorf
Journal:  J Neurol       Date:  1986-10       Impact factor: 4.849

7.  The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus.

Authors:  Hui Ren; Liya Wang; Matthew Bennett; Yuhe Liang; Xiaofeng Zheng; Fei Lu; Lanfen Li; Jie Nan; Ming Luo; Staffan Eriksson; Chuanmao Zhang; Xiao-Dong Su
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-03       Impact factor: 11.205

8.  Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.

Authors:  S H Gultekin; M R Rosenfeld; R Voltz; J Eichen; J B Posner; J Dalmau
Journal:  Brain       Date:  2000-07       Impact factor: 13.501

9.  Potassium channel antibody-associated encephalopathy: a potentially immunotherapy-responsive form of limbic encephalitis.

Authors:  Angela Vincent; Camilla Buckley; Jonathan M Schott; Ian Baker; Bonnie-Kate Dewar; Niels Detert; Linda Clover; Abigail Parkinson; Christian G Bien; Salah Omer; Bethan Lang; Martin N Rossor; Jackie Palace
Journal:  Brain       Date:  2004-02-11       Impact factor: 13.501

10.  Malignant brain tumours associated with adenylate kinase in cerebrospinal fluid.

Authors:  G Ronquist; P Ericsson; G Frithz; R Hugosson
Journal:  Lancet       Date:  1977-06-18       Impact factor: 79.321
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  9 in total

1.  A Genome-Wide Search for Bipolar Disorder Risk Loci Modified by Mitochondrial Genome Variation.

Authors:  Euijung Ryu; Malik Nassan; Gregory D Jenkins; Sebastian M Armasu; Ana Andreazza; Susan L McElroy; Marquis P Vawter; Mark A Frye; Joanna M Biernacka
Journal:  Mol Neuropsychiatry       Date:  2017-10-28

2.  Adenylate kinase 5 (AK5) autoimmune encephalitis: Clinical presentations and outcomes in three new patients.

Authors:  Iman McKeon-Makki; Andrew McKeon; Binxia Yang; Sean J Pittock; Sebastian Lopez-Chiriboga; Lars Komorowski; Ramona Miske; Anastasia Zekeridou
Journal:  J Neuroimmunol       Date:  2022-04-04       Impact factor: 3.221

Review 3.  Adenylate Kinase: A Ubiquitous Enzyme Correlated with Medical Conditions.

Authors:  Mihaela Ileana Ionescu
Journal:  Protein J       Date:  2019-04       Impact factor: 2.371

Review 4.  Rapidly Progressive Dementia.

Authors:  Michael D Geschwind
Journal:  Continuum (Minneap Minn)       Date:  2016-04

5.  Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis.

Authors:  Sergio Muñiz-Castrillo; Julien Jacques Hedou; Aditya Ambati; David Jones; Alberto Vogrig; Anne-Laurie Pinto; Marie Benaiteau; Thomas de Broucker; Laura Fechtenbaum; Pierre Labauge; Matthew Murnane; Claire Nocon; Irina Taifas; Clément Vialatte de Pémille; Dimitri Psimaras; Bastien Joubert; Valérie Dubois; Valentin Wucher; Virginie Desestret; Emmanuel Mignot; Jérôme Honnorat
Journal:  Brain       Date:  2021-10-22       Impact factor: 13.501

6.  Anti-Adenylate Kinase 5 Encephalitis With Histologic Evidence of CNS Vasculitis.

Authors:  Alex Vicino; Valentin Loser; Paolo Salvioni Chiabotti; Jean Philippe Brouland; Renaud Du Pasquier
Journal:  Neurol Neuroimmunol Neuroinflamm       Date:  2021-05-11

7.  Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare AK5 allelic variant in celiac disease development among Saudi patients.

Authors:  Jumana Yousuf Al-Aama; Noor Ahmad Shaik; Babajan Banaganapalli; Mohammed A Salama; Omran Rashidi; Ahmed N Sahly; Mohammed O Mohsen; Harbi A Shawoosh; Hebah Ahmad Shalabi; Mohammad Al Edreesi; Sameer E Alharthi; Jun Wang; Ramu Elango; Omar I Saadah
Journal:  PLoS One       Date:  2017-05-15       Impact factor: 3.240

8.  Rho-associated protein kinase 2 (ROCK2): a new target of autoimmunity in paraneoplastic encephalitis.

Authors:  Stoyan Popkirov; Ilya Ayzenberg; Stefanie Hahn; Jan Bauer; Yvonne Denno; Nicole Rieckhoff; Christiane Radzimski; Volkmar H Hans; Sebastian Berg; Florian Roghmann; Joachim Noldus; Christian G Bien; Sabine Skodda; Jörg Wellmer; Winfried Stöcker; Christos Krogias; Ralf Gold; Uwe Schlegel; Christian Probst; Lars Komorowski; Ramona Miske; Ingo Kleiter
Journal:  Acta Neuropathol Commun       Date:  2017-05-29       Impact factor: 7.801

Review 9.  Autoimmune encephalitis with psychiatric features in adults: historical evolution and prospective challenge.

Authors:  Niels Hansen; Charles Timäus
Journal:  J Neural Transm (Vienna)       Date:  2020-10-07       Impact factor: 3.575
  9 in total

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