Literature DB >> 26438500

Multiple Genetic Mutations Associated with Polymyxin Resistance in Acinetobacter baumannii.

Tze Peng Lim1, Rick Twee-Hee Ong2, Pei-Yun Hon3, Jane Hawkey4, Kathryn E Holt4, Tse Hsien Koh5, Micky Lo-Ngah Leong3, Jocelyn Qi-Min Teo5, Thean Yen Tan6, Mary Mah-Lee Ng3, Li Yang Hsu7.   

Abstract

We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were significant differences in terms of antibiotic susceptibility and genetic determinants of resistance in A. baumannii isolates that had developed polymyxin B resistance in vivo compared to isolates that had developed polymyxin B resistance in vitro.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26438500      PMCID： PMC4649193          DOI： 10.1128/AAC.01884-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Damage of the bacterial cell envelope by antimicrobial peptides gramicidin S and PGLa as revealed by transmission and scanning electron microscopy.

Authors:  Mareike Hartmann; Marina Berditsch; Jacques Hawecker; Mohammad Fotouhi Ardakani; Dagmar Gerthsen; Anne S Ulrich
Journal:  Antimicrob Agents Chemother       Date:  2010-06-07       Impact factor: 5.191

2.  Mauve: multiple alignment of conserved genomic sequence with rearrangements.

Authors:  Aaron C E Darling; Bob Mau; Frederick R Blattner; Nicole T Perna
Journal:  Genome Res       Date:  2004-07       Impact factor: 9.043

Review 3.  Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa.

Authors:  Robert A Bonomo; Dora Szabo
Journal:  Clin Infect Dis       Date:  2006-09-01       Impact factor: 9.079

4.  Modelling time-kill studies to discern the pharmacodynamics of meropenem.

Authors:  Vincent H Tam; Amy N Schilling; Michael Nikolaou
Journal:  J Antimicrob Chemother       Date:  2005-03-16       Impact factor: 5.790

5.  The Sequence Alignment/Map format and SAMtools.

Authors:  Heng Li; Bob Handsaker; Alec Wysoker; Tim Fennell; Jue Ruan; Nils Homer; Gabor Marth; Goncalo Abecasis; Richard Durbin
Journal:  Bioinformatics       Date:  2009-06-08       Impact factor: 6.937

6.  The population structure of Acinetobacter baumannii: expanding multiresistant clones from an ancestral susceptible genetic pool.

Authors:  Laure Diancourt; Virginie Passet; Alexandr Nemec; Lenie Dijkshoorn; Sylvain Brisse
Journal:  PLoS One       Date:  2010-04-07       Impact factor: 3.240

Review 7.  Acinetobacter baumannii: emergence of a successful pathogen.

Authors:  Anton Y Peleg; Harald Seifert; David L Paterson
Journal:  Clin Microbiol Rev       Date:  2008-07       Impact factor: 26.132

8.  Antibiotic resistance in gram-negative bacilli: a Singapore perspective.

Authors:  Thean Yen Tan; Li Yang Hsu; Tse Hsien Koh; Lily S Y Ng; Nancy W S Tee; Prabha Krishnan; Raymond T P Lin; Roland Jureen
Journal:  Ann Acad Med Singapore       Date:  2008-10       Impact factor: 2.473

9.  The cost of resistance to colistin in Acinetobacter baumannii: a proteomic perspective.

Authors:  María Fernández-Reyes; Manuel Rodríguez-Falcón; Cristina Chiva; Jerónimo Pachón; David Andreu; Luis Rivas
Journal:  Proteomics       Date:  2009-03       Impact factor: 3.984

10.  ISfinder: the reference centre for bacterial insertion sequences.

Authors:  P Siguier; J Perochon; L Lestrade; J Mahillon; M Chandler
Journal:  Nucleic Acids Res       Date:  2006-01-01       Impact factor: 16.971
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  8 in total

1.  NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection.

Authors:  N Dikshit; S D Kale; H J Khameneh; V Balamuralidhar; C Y Tang; P Kumar; T P Lim; T T Tan; A L Kwa; A Mortellaro; B Sukumaran
Journal:  Mucosal Immunol       Date:  2017-06-14       Impact factor: 7.313

Review 2.  Chromosomally encoded and plasmid-mediated polymyxins resistance in Acinetobacter baumannii: a huge public health threat.

Authors:  William Gustavo Lima; Mara Cristina Alves; Waleska Stephanie Cruz; Magna Cristina Paiva
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2018-03-09       Impact factor: 3.267

Review 3.  Acinetobacter spp. Infections in Malaysia: A Review of Antimicrobial Resistance Trends, Mechanisms and Epidemiology.

Authors:  Farahiyah Mohd Rani; Nor Iza A Rahman; Salwani Ismail; Ahmed Ghazi Alattraqchi; David W Cleary; Stuart C Clarke; Chew Chieng Yeo
Journal:  Front Microbiol       Date:  2017-12-12       Impact factor: 5.640

4.  In vitro Evaluation of the Colistin-Carbapenem Combination in Clinical Isolates of A. baumannii Using the Checkerboard, Etest, and Time-Kill Curve Techniques.

Authors:  Micheline A H Soudeiha; Elias A Dahdouh; Eid Azar; Dolla K Sarkis; Ziad Daoud
Journal:  Front Cell Infect Microbiol       Date:  2017-05-24       Impact factor: 5.293

5.  Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii.

Authors:  Christine J Boinett; Amy K Cain; Jane Hawkey; Nhu Tran Do Hoang; Nhu Nguyen Thi Khanh; Duy Pham Thanh; Janina Dordel; James I Campbell; Nguyen Phu Huong Lan; Matthew Mayho; Gemma C Langridge; James Hadfield; Nguyen Van Vinh Chau; Guy E Thwaites; Julian Parkhill; Nicholas R Thomson; Kathryn E Holt; Stephen Baker
Journal:  Microb Genom       Date:  2019-02-05

Review 6.  Carbapenem Resistance in Gram-Negative Bacteria: The Not-So-Little Problem in the Little Red Dot.

Authors:  Jocelyn Qi Min Teo; Yiying Cai; Tze-Peng Lim; Thuan Tong Tan; Andrea Lay-Hoon Kwa
Journal:  Microorganisms       Date:  2016-02-16

7.  Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection.

Authors:  Jane Hawkey; David B Ascher; Louise M Judd; Ryan R Wick; Xenia Kostoulias; Heather Cleland; Denis W Spelman; Alex Padiglione; Anton Y Peleg; Kathryn E Holt
Journal:  Microb Genom       Date:  2018-03-16

Review 8.  Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens.

Authors:  Stephen Baker; Nicholas Thomson; François-Xavier Weill; Kathryn E Holt
Journal:  Science       Date:  2018-05-18       Impact factor: 47.728
  8 in total

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