Jackie Leung1, Junseok A Kim2, Andrea Kassner1,3. 1. Department of Physiology and Experimental Medicine, the Hospital for Sick Children, Toronto, Ontario, Canada. 2. Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada. 3. Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada.
Abstract
PURPOSE: To evaluate the reproducibility of cerebrovascular reactivity (CVR) measurements acquired in children using magnetic resonance imaging (MRI) in combination with a computer-controlled carbon dioxide (CO2 ) stimulus. MATERIALS AND METHODS: Ten healthy children (age 16.1 ± 1.6 years) underwent CVR imaging on a 3T scanner using a blood-oxygen level-dependent (BOLD) MRI sequence. Targeted hypercapnia was induced during imaging with a CO2 gas challenge delivered using a specialized gas sequencer (RespirAct). A total of four BOLD scans were performed over 2 separate days to test within-day and between-day consistency of the data. CVR values were computed by correlating the relative change in BOLD signal in response to the CO2 stimulus delivered to the each subject. RESULTS: Intraclass correlation coefficients (ICCs) of within-day values show highly reproducible measures in both the gray matter (ICC = 0.857, P < 0.001) and white matter (ICC = 0.895, P < 0.001). Relatively lower between-day reproducibility was observed in both the gray matter (ICC = 0.776, P = 0.001) and white matter (ICC = 0.719, P = 0.004). CONCLUSION: Using a computer-controlled CO2 stimulus, we have demonstrated the reliability of BOLD-CVR measurements in pediatric subjects. Within-day and between-day metrics of reproducibility were comparable to adult data.
PURPOSE: To evaluate the reproducibility of cerebrovascular reactivity (CVR) measurements acquired in children using magnetic resonance imaging (MRI) in combination with a computer-controlled carbon dioxide (CO2 ) stimulus. MATERIALS AND METHODS: Ten healthy children (age 16.1 ± 1.6 years) underwent CVR imaging on a 3T scanner using a blood-oxygen level-dependent (BOLD) MRI sequence. Targeted hypercapnia was induced during imaging with a CO2 gas challenge delivered using a specialized gas sequencer (RespirAct). A total of four BOLD scans were performed over 2 separate days to test within-day and between-day consistency of the data. CVR values were computed by correlating the relative change in BOLD signal in response to the CO2 stimulus delivered to the each subject. RESULTS: Intraclass correlation coefficients (ICCs) of within-day values show highly reproducible measures in both the gray matter (ICC = 0.857, P < 0.001) and white matter (ICC = 0.895, P < 0.001). Relatively lower between-day reproducibility was observed in both the gray matter (ICC = 0.776, P = 0.001) and white matter (ICC = 0.719, P = 0.004). CONCLUSION: Using a computer-controlled CO2 stimulus, we have demonstrated the reliability of BOLD-CVR measurements in pediatric subjects. Within-day and between-day metrics of reproducibility were comparable to adult data.
Authors: Moss Y Zhao; Amanda Woodward; Audrey P Fan; Kevin T Chen; Yannan Yu; David Y Chen; Michael E Moseley; Greg Zaharchuk Journal: J Cereb Blood Flow Metab Date: 2021-11-22 Impact factor: 6.960
Authors: Moss Y Zhao; Audrey P Fan; David Yen-Ting Chen; Magdalena J Sokolska; Jia Guo; Yosuke Ishii; David D Shin; Mohammad Mehdi Khalighi; Dawn Holley; Kim Halbert; Andrea Otte; Brittney Williams; Taghi Rostami; Jun-Hyung Park; Bin Shen; Greg Zaharchuk Journal: Neuroimage Date: 2021-03-11 Impact factor: 6.556
Authors: Emilie Sleight; Michael S Stringer; Ian Marshall; Joanna M Wardlaw; Michael J Thrippleton Journal: Front Physiol Date: 2021-02-25 Impact factor: 4.566
Authors: Peiying Liu; Dengrong Jiang; Marilyn Albert; Christopher E Bauer; Arvind Caprihan; Brian T Gold; Steven M Greenberg; Karl G Helmer; Kay Jann; Gregory Jicha; Pavel Rodriguez; Claudia L Satizabal; Sudha Seshadri; Herpreet Singh; Jeffrey F Thompson; Danny J J Wang; Hanzhang Lu Journal: Neuroimage Date: 2021-11-23 Impact factor: 7.400
Authors: W Alan C Mutch; Michael J Ellis; Lawrence N Ryner; Marc P Morissette; Philip J Pries; Brenden Dufault; Marco Essig; David J Mikulis; James Duffin; Joseph A Fisher Journal: Front Neurol Date: 2016-07-08 Impact factor: 4.003
Authors: W Alan C Mutch; Michael J Ellis; Lawrence N Ryner; Patrick J McDonald; Marc P Morissette; Philip Pries; Marco Essig; David J Mikulis; James Duffin; Joseph A Fisher Journal: Front Neurol Date: 2018-01-24 Impact factor: 4.003