| Literature DB >> 26433072 |
Aritz Lopategi1, Cristina López-Vicario2, José Alcaraz-Quiles2, Verónica García-Alonso2, Bibiana Rius2, Esther Titos3, Joan Clària4.
Abstract
White adipose tissue is recognized as an active endocrine organ implicated in the maintenance of metabolic homeostasis. However, adipose tissue function, which has a crucial role in the development of obesity-related comorbidities including insulin resistance and non-alcoholic fatty liver disease, is dysregulated in obese individuals. This review explores the physiological functions and molecular actions of bioactive lipids biosynthesized in adipose tissue including sphingolipids and phospholipids, and in particular fatty acids derived from phospholipids of the cell membrane. Special emphasis is given to polyunsaturated fatty acids of the omega-6 and omega-3 families and their conversion to bioactive lipid mediators through the cyclooxygenase and lipoxygenase pathways. The participation of omega-3-derived lipid autacoids in the resolution of adipose tissue inflammation and in the prevention of obesity-associated hepatic complications is also thoroughly discussed.Entities:
Keywords: Adipose tissue; Lipid mediators; Omega-6 and omega-3 fatty acids
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Year: 2015 PMID： 26433072 DOI： 10.1016/j.mce.2015.09.033
Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102