Literature DB >> 26432763

Targeting Treg signaling for the treatment of autoimmune diseases.

Allyson Spence1, Joanna E Klementowicz1, Jeffrey A Bluestone2, Qizhi Tang3.   

Abstract

Regulatory T (Treg) cells are crucial players in the prevention of autoimmunity. Treg lineage commitment and functional stability are influenced by selected extracellular signals from the local environment, shaped by distinctive intracellular signaling network, and secured by their unique epigenetic profile. Recent advances in our understanding of the complex processes of Treg lineage differentiation, maintenance, and function has paved the way for developing strategies to manipulate these important cells for therapeutic benefit in many diseases. In this review, we will summarize recent advances in our understanding of Treg biology as well as Treg-targeted therapies in the context of autoimmune disease.
Copyright © 2015 Elsevier Ltd. All rights reserved.

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Year:  2015        PMID： 26432763      PMCID： PMC4679451          DOI： 10.1016/j.coi.2015.09.002

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  114 in total

1.  The T cell-selective IL-2 mutant AIC284 mediates protection in a rat model of Multiple Sclerosis.

Authors:  Andreas Weishaupt; Daniela Paulsen; Sandra Werner; Nelli Wolf; Gabriele Köllner; Helga Rübsamen-Schaeff; Thomas Hünig; Thomas Kerkau; Niklas Beyersdorf
Journal:  J Neuroimmunol       Date:  2015-03-27       Impact factor: 3.478

Review 2.  New cell sources for T cell engineering and adoptive immunotherapy.

Authors:  Maria Themeli; Isabelle Rivière; Michel Sadelain
Journal:  Cell Stem Cell       Date:  2015-04-02       Impact factor: 24.633

Review 3.  Epigenetic and transcriptional control of Foxp3+ regulatory T cells.

Authors:  Jochen Huehn; Marc Beyer
Journal:  Semin Immunol       Date:  2015-03-20       Impact factor: 11.130

4.  Function of a Foxp3 cis-element in protecting regulatory T cell identity.

Authors:  Xudong Li; Yuqiong Liang; Mathias LeBlanc; Chris Benner; Ye Zheng
Journal:  Cell       Date:  2014-08-14       Impact factor: 41.582

5.  Effects of low-dose recombinant interleukin 2 to promote T-regulatory cells in alopecia areata.

Authors:  Emeline Castela; Florence Le Duff; Catherine Butori; Michel Ticchioni; Paul Hofman; Philippe Bahadoran; Jean-Philippe Lacour; Thierry Passeron
Journal:  JAMA Dermatol       Date:  2014-07       Impact factor: 10.282

6.  CD5 instructs extrathymic regulatory T cell development in response to self and tolerizing antigens.

Authors:  Jacob G Henderson; Adeleye Opejin; Andrew Jones; Cindy Gross; Daniel Hawiger
Journal:  Immunity       Date:  2015-03-17       Impact factor: 31.745

7.  The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation.

Authors:  Michel DuPage; Gaurav Chopra; Jason Quiros; Wendy L Rosenthal; Malika M Morar; Dan Holohan; Ruan Zhang; Laurence Turka; Alexander Marson; Jeffrey A Bluestone
Journal:  Immunity       Date:  2015-02-10       Impact factor: 31.745

8.  HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse.

Authors:  Massimo F Martelli; Mauro Di Ianni; Loredana Ruggeri; Franca Falzetti; Alessandra Carotti; Adelmo Terenzi; Antonio Pierini; Maria Speranza Massei; Lucia Amico; Elena Urbani; Beatrice Del Papa; Tiziana Zei; Roberta Iacucci Ostini; Debora Cecchini; Rita Tognellini; Yair Reisner; Franco Aversa; Brunangelo Falini; Andrea Velardi
Journal:  Blood       Date:  2014-06-12       Impact factor: 22.113

9.  Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells.

Authors:  Dean Franckaert; James Dooley; Evelyne Roos; Stefan Floess; Jochen Huehn; Herve Luche; Hans Joerg Fehling; Adrian Liston; Michelle A Linterman; Susan M Schlenner
Journal:  Immunol Cell Biol       Date:  2014-12-23       Impact factor: 5.126

10.  Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition.

Authors:  Brian M Weist; Nadia Kurd; Jeremy Boussier; Shiao Wei Chan; Ellen A Robey
Journal:  Nat Immunol       Date:  2015-05-04       Impact factor: 25.606
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  33 in total

Review 1.  The multiple pathways to autoimmunity.

Authors:  Argyrios N Theofilopoulos; Dwight H Kono; Roberto Baccala
Journal:  Nat Immunol       Date:  2017-06-20       Impact factor: 25.606

2.  Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3.

Authors:  Angelika Schmidt; Francesco Marabita; Narsis A Kiani; Catharina C Gross; Henrik J Johansson; Szabolcs Éliás; Sini Rautio; Matilda Eriksson; Sunjay Jude Fernandes; Gilad Silberberg; Ubaid Ullah; Urvashi Bhatia; Harri Lähdesmäki; Janne Lehtiö; David Gomez-Cabrero; Heinz Wiendl; Riitta Lahesmaa; Jesper Tegnér
Journal:  BMC Biol       Date:  2018-05-07       Impact factor: 7.431

3.  OX40L/OX40 axis impairs follicular and natural Treg function in human SLE.

Authors:  Clément Jacquemin; Jean-François Augusto; Marc Scherlinger; Noémie Gensous; Edouard Forcade; Isabelle Douchet; Emeline Levionnois; Christophe Richez; Estibaliz Lazaro; Pierre Duffau; Marie-Elise Truchetet; Julien Seneschal; Lionel Couzi; Jean-Luc Pellegrin; Jean-François Viallard; Thierry Schaeverbeke; Virginia Pascual; Cécile Contin-Bordes; Patrick Blanco
Journal:  JCI Insight       Date:  2018-12-20

Review 4.  Autonomic regulation of T-lymphocytes: Implications in cardiovascular disease.

Authors:  Safwan K Elkhatib; Adam J Case
Journal:  Pharmacol Res       Date:  2019-06-06       Impact factor: 7.658

Review 5.  Treg cells in autoimmunity: from identification to Treg-based therapies.

Authors:  Lisa Göschl; Clemens Scheinecker; Michael Bonelli
Journal:  Semin Immunopathol       Date:  2019-04-05       Impact factor: 9.623

6.  Treg-Cell Control of a CXCL5-IL-17 Inflammatory Axis Promotes Hair-Follicle-Stem-Cell Differentiation During Skin-Barrier Repair.

Authors:  Anubhav N Mathur; Bahar Zirak; Ian C Boothby; Madge Tan; Jarish N Cohen; Thea M Mauro; Pooja Mehta; Margaret M Lowe; Abul K Abbas; Niwa Ali; Michael D Rosenblum
Journal:  Immunity       Date:  2019-03-19       Impact factor: 31.745

7.  Ectopic Expression of Self-Antigen Drives Regulatory T Cell Development and Not Deletion of Autoimmune T Cells.

Authors:  Thomas Lee; Maran L Sprouse; Pinaki Banerjee; Maria Bettini; Matthew L Bettini
Journal:  J Immunol       Date:  2017-08-23       Impact factor: 5.422

Review 8.  Empowering Regulatory T Cells in Autoimmunity.

Authors:  Isaac R Kasper; Sokratis A Apostolidis; Amir Sharabi; George C Tsokos
Journal:  Trends Mol Med       Date:  2016-07-25       Impact factor: 11.951

Review 9.  Impact of Immune-Modulatory Drugs on Regulatory T Cell.

Authors:  Akiko Furukawa; Steven A Wisel; Qizhi Tang
Journal:  Transplantation       Date:  2016-11       Impact factor: 4.939

10.  Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.

Authors:  Hiroaki Shime; Mizuyu Odanaka; Makoto Tsuiji; Takuma Matoba; Masaki Imai; Yoshiaki Yasumizu; Ryuta Uraki; Kiyoshi Minohara; Maiko Watanabe; Anthony John Bonito; Hidehiro Fukuyama; Naganari Ohkura; Shimon Sakaguchi; Akimichi Morita; Sayuri Yamazaki
Journal:  Proc Natl Acad Sci U S A       Date:  2020-08-07       Impact factor: 11.205
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