| Literature DB >> 26432017 |
Diana Sousa1, Raquel T Lima2, M Helena Vasconcelos3.
Abstract
Extracellular vesicles (EVs) are nanosized particles (100-1000 nm) enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication. The role of EVs in oncobiology has been extensively studied, including their contribution to the horizontal transfer of drug resistance from drug-resistant to drug-sensitive cancer cells. This review focuses on the EVs cargo responsible for this intercellular transfer of drug resistance; namely, drug-efflux pumps, miRNAs, long noncoding RNAs (lncRNAs), and other mediators. Additionally, the known molecular mechanisms and features of this transfer are discussed. This is an emerging area of research and we highlight topics that need to be further studied to fully understand and counteract the intercellular transfer of drug resistance mediated by EVs.Entities:
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Year: 2015 PMID： 26432017 DOI： 10.1016/j.molmed.2015.08.002
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951