Literature DB >> 2643113

A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).

G P Schwartz1, G T Burke, P G Katsoyannis.   

Abstract

An insulin analogue that embodies two distinct structural modifications, each of which independently increases insulin activity, has been synthesized and evaluated for biological activity. The analogue, des-(B26-B30)-[AspB10,TyrB25-NH2]insulin is the most potent insulin analogue yet described; it displays an 11- to 13-fold higher activity than natural insulin. The findings are discussed with regard to the receptor-binding domains of insulin.

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Year:  1989        PMID： 2643113      PMCID： PMC286489          DOI： 10.1073/pnas.86.2.458

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  20 in total

1.  Is the evolution of insulin Darwinian or due to selectively neutral mutation?

Authors:  T L Blundell; S P Wood
Journal:  Nature       Date:  1975-09-18       Impact factor: 49.962

2.  [B-chain shortening of matrix-bound insulin by pepsin, I:Preparation and properties of bovine des-pentapeptide(B26-30) insulin (suthor's transl)].

Authors:  H G Gattner
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1975-09

3.  Chemical synthesis of [des(tetrapeptide B27--30), Tyr(NH2)26-B] and [des(pentapeptide B26--30), Phe(NH2)25-B] bovine insulins.

Authors:  A Cosmatos; N Ferderigos; P G Katsoyannis
Journal:  Int J Pept Protein Res       Date:  1979

4.  Synthesis of destetrapeptide B27-30 human (porcine) insulin. A biologically active insulin analog.

Authors:  P G Katsoyannis; J Ginos; A Cosmatos; G Schwart
Journal:  J Am Chem Soc       Date:  1973-09-19       Impact factor: 15.419

5.  Synthesis of a biologically active truncated insulin. Des(pentapeptide B23-30) human (porcine) insulin.

Authors:  P G Katsoyannis; J Ginos; G P Schwartz; A Cosmatos
Journal:  J Chem Soc Perkin 1       Date:  1974

6.  Analogs of insulin. 1. Synthesis of destripeptide B 28-30 bovine insulin and destripeptide B 28-30 porcine (human) insulin.

Authors:  P G Katsoyannis; C Zalut; A Harris; R J Meyer
Journal:  Biochemistry       Date:  1971-10-12       Impact factor: 3.162

7.  Color test for detection of free terminal amino groups in the solid-phase synthesis of peptides.

Authors:  E Kaiser; R L Colescott; C D Bossinger; P I Cook
Journal:  Anal Biochem       Date:  1970-04       Impact factor: 3.365

8.  Receptor-binding region of insulin.

Authors:  R A Pullen; D G Lindsay; S P Wood; I J Tickle; T L Blundell; A Wollmer; G Krail; D Brandenburg; H Zahn; J Gliemann; S Gammeltoft
Journal:  Nature       Date:  1976-02-05       Impact factor: 49.962

9.  Studies on the synthesis of insulin from natural and synthetic A and B chains. I. Splitting of insulin and isolation of the S-sulfonated derivatives of the A and B chains.

Authors:  P G Katsoyannis; A Tometsko; C Zalut; S Johnson; A C Trakatellis
Journal:  Biochemistry       Date:  1967-09       Impact factor: 3.162

10.  [12-asparagine-B] human insulin. An analogue with modification in the hydrophobic core of insulin.

Authors:  G P Schwartz; G T Burke; P G Katsoyannis
Journal:  Int J Pept Protein Res       Date:  1981-02
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  5 in total

1.  Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.

Authors:  Q X Hua; M Kochoyan; M A Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-15       Impact factor: 11.205

2.  Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains.

Authors:  Bin Xu; Kun Huang; Ying-Chi Chu; Shi-Quan Hu; Satoe Nakagawa; Shuhua Wang; Run-Ying Wang; Jonathan Whittaker; Panayotis G Katsoyannis; Michael A Weiss
Journal:  J Biol Chem       Date:  2009-03-25       Impact factor: 5.157

3.  The solution structure of a superpotent B-chain-shortened single-replacement insulin analogue.

Authors:  G Kurapkat; M Siedentop; H G Gattner; M Hagelstein; D Brandenburg; J Grötzinger; A Wollmer
Journal:  Protein Sci       Date:  1999-03       Impact factor: 6.725

4.  An insulin-like hybrid consisting of a modified A-domain of human insulin-like growth factor I and the B-chain of insulin.

Authors:  L Zong; G T Burke; P G Katsoyannis
Journal:  J Protein Chem       Date:  1990-08

5.  The A14 position of insulin tolerates considerable structural alterations with modest effects on the biological behavior of the hormone.

Authors:  Y C Chu; L Zong; G T Burke; P G Katsoyannis
Journal:  J Protein Chem       Date:  1992-10
  5 in total

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