Literature DB >> 169474

Is the evolution of insulin Darwinian or due to selectively neutral mutation?

T L Blundell, S P Wood.   

Abstract

A model for the evolution of insulin mainly in terms of adaptive processes is discussed. The model depends critically on the relationship of sequence changes to the three-dimensional structure and the role of various parts of this structure in the conversion of the proinsulin molecule to the active form, the storage of insulin, its transport to the site of action and its interaction with a receptor.

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Year:  1975        PMID： 169474     DOI： 10.1038/257197a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  29 in total

1.  Functional aspects of hemoglobin evolution in the mammals.

Authors:  A F Scott; H F Bunn; A H Brush
Journal:  J Mol Evol       Date:  1976-12-30       Impact factor: 2.395

2.  Constraints on HIV-1 diversity from protein structure.

Authors:  Jeongmin Woo; David L Robertson; Simon C Lovell
Journal:  J Virol       Date:  2010-09-29       Impact factor: 5.103

3.  A highly potent insulin: des-(B26-B30)-[AspB10,TyrB25-NH2]insulin(human).

Authors:  G P Schwartz; G T Burke; P G Katsoyannis
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

4.  Structure and receptor-binding activity of insulin from a holostean fish, the bowfin (Amia calva).

Authors:  J M Conlon; J H Youson; J Whittaker
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

Review 5.  In the light of directed evolution: pathways of adaptive protein evolution.

Authors:  Jesse D Bloom; Frances H Arnold
Journal:  Proc Natl Acad Sci U S A       Date:  2009-06-15       Impact factor: 11.205

Review 6.  Structural and functional constraints in the evolution of protein families.

Authors:  Catherine L Worth; Sungsam Gong; Tom L Blundell
Journal:  Nat Rev Mol Cell Biol       Date:  2009-09-16       Impact factor: 94.444

7.  Orthologous nature of mammalian insulin genes.

Authors:  J J Beintema
Journal:  J Mol Evol       Date:  1977-08-05       Impact factor: 2.395

8.  On the overdispersed molecular clock.

Authors:  N Takahata
Journal:  Genetics       Date:  1987-05       Impact factor: 4.562

9.  Isolation of the human insulin-like growth factor genes: insulin-like growth factor II and insulin genes are contiguous.

Authors:  G I Bell; D S Gerhard; N M Fong; R Sanchez-Pescador; L B Rall
Journal:  Proc Natl Acad Sci U S A       Date:  1985-10       Impact factor: 11.205

Review 10.  Evolutionary biochemistry: revealing the historical and physical causes of protein properties.

Authors:  Michael J Harms; Joseph W Thornton
Journal:  Nat Rev Genet       Date:  2013-08       Impact factor: 53.242
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